High-Risk HPV DNA Detection Rate in Patients with Atypical Squamous Cells and Its Relationship to the Atypical Squamous Cell:Squamous Intraepithelial Lesion Ratio

Chhieng, David C.; Connolly, Kathy; Roberson, Janie; Eltoum, Isam

doi:10.1159/000325956

Cited by 12 publications

(10 citation statements)

References 12 publications

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“…We particularly want to emphasize that 253 (59.4%) of 426 HPV-positive ATC cases were classified CIN 1/1+ as shown in Table 2, and importantly, that two cases of invasive cancers were detected in this new screening program. This figure is again similar to that reported for the USA and Europe [12][13][14][15][16]. Nevertheless, the vagueness surrounding the definition of ATC warrants further study.…”

Section: Discussionsupporting

confidence: 88%

Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan

Inoue

Okamura²,

Hashimoto

et al. 2010

International Journal of Gynecology & Obstetrics

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Section: Discussionsupporting

confidence: 88%

Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan

Inoue

Okamura²,

Hashimoto

et al. 2010

International Journal of Gynecology & Obstetrics

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“…To avoid potential misuse of the ASC interpretation, it is recommended that the frequency of ASC interpretation should be no greater than 5% of the patient population [25]. In our study, the rate of ASC-US was 3.1%.…”

Section: Discussionmentioning

confidence: 58%

Evaluation of the Oncogenic Human Papillomavirus DNA Test with Liquid-Based Cytology in Primary Cervical Cancer Screening and the Importance of the ASC/SIL Ratio: A Belgian Study

Catteau

Simon

Noël

2014

ISRN Obstetrics and Gynecology

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Objectives. In Belgium, very few studies have focused on cervical high-risk human papillomaviruses (hrHPV) prevalence and the relationship between HPV and cervical cytological abnormalities. The aim of this study was to investigate hrHPV prevalence and its relationship with cytological screening and histological results in the French-speaking community in Belgium (Brussels and Wallonia). Methods. A total of 58,265 liquid-based cytology tests were performed during this period. All cases of ASC-US, ASC-H, LSIL, and HSIL were tested by Hybrid Capture 2 for hrHPV screening. Results. The prevalence of cytological abnormalities was 3.1% for ASC-US, 0.3% for ASC-H, 1.5% for LSIL, and 0.3% for HSIL. The frequency of hrHPV infection was 47% in ASC-US, 90% in ASC-H, 86% in LSIL, and 98.4% in HSIL. CIN 2+ lesions were found in 12.2% of smears with an ASC-US result, in 54% of smears with an ASC-H result, in 12.5% of smears with a LSIL result, and in 89.3% of smears with a HSIL result. The ASC/SIL ratio was 1.9%. Conclusions. This study provides a good representation of cytological abnormalities and HPV status in patients living in Belgium's French-speaking community. The prevalence in our study was similar to that derived from meta-analyses of European studies. Our ASC/SIL ratio was 1.9%, being within the lower and upper limits proposed in the literature, which tends to prove the good quality diagnosis of cervical smears in our laboratory.

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“…A recent study by Chhieng et al did not find an association between the HPV rate and the ASC:SIL for their laboratory 12. In their study, the overall HPV‐positive rate was 34% with an overall ASC:SIL ratio of 2.0.…”

Section: Discussionmentioning

confidence: 75%

Testing for HPV as an objective measure for quality assurance in gynecologic cytology

Nanji

Tambouret

et al. 2007

Cancer

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High-Risk HPV DNA Detection Rate in Patients with Atypical Squamous Cells and Its Relationship to the Atypical Squamous Cell:Squamous Intraepithelial Lesion Ratio

Cited by 12 publications

References 12 publications

Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan

Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan

Evaluation of the Oncogenic Human Papillomavirus DNA Test with Liquid-Based Cytology in Primary Cervical Cancer Screening and the Importance of the ASC/SIL Ratio: A Belgian Study

Testing for HPV as an objective measure for quality assurance in gynecologic cytology

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