High-risk HPV testing improves accuracy in detection of CIN2+ lesions in ASC-H postmenopausal women? An academic hospital experiences

Salibay, Christine; Chen, Zhengshan; Ma, Bo; Hui, Pei; Hijazi, Maya; Elatre, Wafaa; Shulman, Ira A.; Martin, Sue Ellen; Wang, Tiannan

doi:10.1016/j.jasc.2022.08.004

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…After adjusting for HR-HPV, the risks of cytologic abnormalities rose among current smokers under 45 (OR: 3.3 (2.0, 17.9). (15,16), that our study discovered that as age grew, there was less of a link between the detection of "HR-HPV" and cytological issues.…”

Section: Resultsmentioning

confidence: 73%

relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women

Javed,

Nadeem,

Arif

et al. 2023

ijhs

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Background: In this research, premenopausal women with HR-HPV infections and atypical cervical smears were compared by age. Materials and method: 200 regularly screened women between the ages of 36 and 60 had a cervical smear and HPV detection. Demographic, behavioral, and medical data were gathered by telephone surveys. Descriptive analysis was used to look at the connection between HR-HPV infections and cervical aberrations by age. Results: Age significantly decreased the number of cases of cervical abnormalities, HR-HPV, and human papillomavirus, as well as the correlation among these disorders. In younger females with abnormalities, HR-HPV detection was 60%; however, it steadily decreased to 30% in "50-54-year-old" women, without abnormalities found in 55-60 years old females. Different relationships between HR-HPV infection and anomalies remained found in females over 45, a pattern not observed in females who were young by age. Conclusion: Age had no effect on several kinds of low-grade and severe anomalies, but we saw a decline in the agreement among cytological results and HR-HPV tests.

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Section: Resultsmentioning

confidence: 73%

relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women

Javed,

Nadeem,

Arif

et al. 2023

ijhs

View full text Add to dashboard Cite

show abstract

“…Therefore, a colposcopy examination should be considered for women with ASC-H cytology, with HPV triaging. 18,[30][31][32] High-grade intraepithelial neoplasia (HSIL): In general, HSIL cells are smaller, and show less cytoplasmic maturity. Furthermore, the N/C ratio markedly increases with no visually discernible cytoplasm.…”

Section: Interpretations/results 12mentioning

confidence: 99%

Updates in Cervical Cancer Screening Guidelines, The Bethesda System for Reporting Cervical Cytology, and Clinical Management Recommendations

Wang¹,

Zhang²,

Liu³

et al. 2023

J Clin Transl Pathol

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Over the past decades, cervical cancer has been a worldwide public health problem. Population-based early cancer risk detection and prevention approaches, including vaccination, cytology screening and human papilloma virus (HPV) detection, with the aligned clinical management, have formed a well-rounded high-quality implementation system for cervical cancer control, and revolutionarily improved the quality of life of women: (1) the success of cervical cancer screening practices, (2) standardization of The Bethesda system for reporting cervicovaginal cytology, (3) improvement in the understanding of HPV pathogenesis in cervical cancer, and (4) the development of appropriate management approaches have significantly decreased the disease burden of cervical cancer worldwide. This scoping review aimed to understand the evolvement of cervical cancer screening and management guidelines, describe the Bethesda cervical cytology reporting system, and HPV vaccines and tests, and highlight the key information of present policies and practices.

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Genotype profile of HPV in ASC‐H cytology and histologic follow‐up—prevalence, distribution, and risk: A retrospective study of 1414 cases

Sun,

Wang,

Zhong

et al. 2024

Cancer Cytopathology

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BackgroundA cytologic diagnosis of atypical squamous cells, cannot exclude high‐grade squamous lesion (ASC‐H) poses a disproportionately high risk of cervical cancer development. The objective of this study was to analyze type‐specific risks by mapping human papillomavirus (HPV) genotypes in ASC‐H cytology.MethodsIn total, 1,048,581 Papanicolaou tests that had ASC‐H cytology were retrieved. Concurrent HPV genotyping using proprietary multiplex real‐time (MRT) and polymerase chain reaction (PCR) HPV tests and histologic follow‐up findings were analyzed.ResultsAmong 1678 patients who had ASC‐H findings (0.16%), 1414 (84.3%) underwent concurrent HPV genotyping (MRT, 857; HPV PCR test, 557). The overall high‐risk HPV (hrHPV)‐positive rate was 84.4%. Of the 857 MRT cases, 63.9% were infected with a single hrHPV, and 24.4% had multiple genotypes. The most prevalent HPV types were HPV16/52/58/33/31. Lesions that were identified as cervical intraepithelial neoplasia 2 or worse (CIN2+) were detected in 498 of 906 cases (55.0%), including 81 cervical carcinomas (8.9%). The risk of CIN2+ for the composite group of HPV16/52/58/33/31‐positive cases was 62.7%, representing 90.7% (264 of 291) of total CIN2+ lesions in ASC‐H/hrHPV–positive cases by MRT. CIN2+ lesions were detected in 108 of 142 (76.1%) HPV16‐positive and/or HPV18‐positive women by the PCR the HPV test. Among 128 hrHPV‐negative ASC‐H cases by both methods, CIN2+ lesions were identified in 21 of 128 (16.4%), including five cervical carcinomas (3.9%). The sensitivity, specificity, positive predictive value, and negative predictive value for patients in the composite group with HPV16/52/58/33/31 were 88.0%, 40.8%, 62.7%, and 75.0%, respectively.ConclusionsPapanicolaou tests classified as ASC‐H are associated with a high CIN2+ rate and warrant colposcopy, regardless of HPV status. The extent to which the risk‐stratification provided by comprehensive HPV genotyping can inform the management of ASC‐H cytology remains to be explored.

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High-risk HPV testing improves accuracy in detection of CIN2+ lesions in ASC-H postmenopausal women? An academic hospital experiences

Cited by 3 publications

References 16 publications

relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women

relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women

Updates in Cervical Cancer Screening Guidelines, The Bethesda System for Reporting Cervical Cytology, and Clinical Management Recommendations

Genotype profile of HPV in ASC‐H cytology and histologic follow‐up—prevalence, distribution, and risk: A retrospective study of 1414 cases

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