High‐Salt Diet‐Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet

Li, Ya; Li, Wen; Xiao, Wang; Ding, Chao; Liu, Junze; Li, Yan; Li, Wenjuan; Sun, Yuan

doi:10.1002/mnfr.201900965

Cited by 16 publications

(11 citation statements)

References 66 publications

(86 reference statements)

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“…Finally, Metastats analysis was performed to compare the significant differences between the groups at the genus level, and the linear discriminant analysis effect size (LEfSe) analysis was used to screen the biomarkers with statistical differences between the groups (LDA score > 4). The “cor.test” function in the statistical software R was used to calculate the Spearman correlation coefficient between the microbial community and gout symptoms, visualized with a heat map ( Li et al, 2020a ). PICRUSt was used to infer the metabolic functions of the intestinal microbiota and to predict the molecular function of each sample based on the sequences of 16S rRNA-tagged genes ( Langille et al, 2013 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice

Feng

Chen

et al. 2022

Front. Microbiol.

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As a chronic metabolic disease caused by disorders of purine metabolism, gout has shown increasing incidence rate worldwide. Considering that gout is not easily treated and cured, further studies are explored to prevent gout development through diet modification. Both β-carotin and green tea powder are rich in dietary fiber, which helps maintain the balance of gut microbiota in humans. The aim of this study was to investigate the effects of β-carotin and green tea powder diet on the prevention of gouty arthritis in relation to the bacterial structure of gut microbiota in mice. We successfully induced gouty arthritis in C57BL/6 mice by injecting monosodium urate (MSU) crystals and feeding high-fat diet (HFD), and further investigated the effects of additional β-carotin and green tea powder in the diets of mice on the prevention of gouty arthritis in mice. Our results showed that diet of β-carotin and green tea powder reduced the joint swelling and pain in mice with gout, reduced the levels of serum uric acid (UA) and three types of pro-inflammatory cytokines, i.e., interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), improved the gut microbiota profile, and reduced the metabolic levels of purines and pyrimidines. In conclusion, our study provided evidence to support the application of β-carotin and green tea powder diet as a dietary adjustment method to prevent and treat gouty arthritis.

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Section: Methodsmentioning

confidence: 99%

Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice

Feng

Chen

et al. 2022

Front. Microbiol.

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“…Hence, studies on the effects of TBW on the host microbiome are new and promising in animal models. We used a TBWF containing TBW (50%) and Chenopodium quinoa (50%) to serve as a candidate diet for modulating the gut microbiota 45 , 46 and host BP homeostasis 47 , 48 in SHRs. We aimed to explore the similarity between the microbial composition of SHR after TBWF intervention and that of WKY controls.…”

Section: Resultsmentioning

confidence: 99%

Kidney microbiota dysbiosis contributes to the development of hypertension

Liu

Zhang

et al. 2022

Gut Microbes

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Gut microbiota dysbiosis promotes metabolic syndromes (e.g., hypertension); however, the patterns that drive hypertensive pathology and could be targeted for therapeutic intervention are unclear. We hypothesized that gut microbes might translocate to the kidney to trigger hypertension. We aimed to uncover their method of colonization, and thereby how to maintain blood pressure homeostasis. Using combined approaches based on fluorescence in situ hybridization (FISH) and immunofluorescence staining, electron microscopy analysis, bacterial cultures, species identification, and RNA-sequencing-based meta-transcriptomics, we first demonstrated the presence of bacteria within the kidney of spontaneously hypertensive rats (SHRs) and its normotensive counterpart, Wistar-Kyoto rats (WKYs), and patients with hypertension. Translocated renal bacteria were coated with secretory IgA (sIgA) or remained dormant in the L-form. Klebsiella pneumoniae ( K.pn ) was identified in the kidneys of germ-free (GF) mice following intestinal transplantation, which suggested an influx of gut bacteria into the kidneys. Renal bacterial taxa and their function are associated with hypertension. Hypertensive hosts showed increased richness in the pathobionts of their kidneys, which were partly derived from the gastrointestinal tract. We also demonstrated the indispensable role of bacterial IgA proteases in the translocation of live microbes. Furthermore, Tartary buckwheat dietary intervention reduced blood pressure and modulated the core renal flora-host ecosystem to near-normal states. Taken together, the unique patterns of viable and dormant bacteria in the kidney provide insight into the pathogenesis of non-communicable chronic diseases and cardiometabolic diseases (e.g., hypertension), and may lead to potential novel microbiota-targeted dietary therapies.

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“…The World Health Organization recommends a maximum salt intake of 5 g/day 32 . The proposed mechanisms by which salt can cause gastric cancer include via direct damage to the gastric mucosa leading to hyperplasia of the gastric pit epithelium, with increased potential for mutations 33 . A high sodium intake has also been reported to potentially alter the viscosity of the protective mucous barrier and increase colonization by H. pylori , as a recognized risk factor for gastric cancer 34 , 35 .…”

Section: Discussionmentioning

confidence: 99%

The burden and trend of gastric cancer and possible risk factors in five Asian countries from 1990 to 2019

Ning

Lyu

Pei

et al. 2022

Sci Rep

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The burdens and trends of gastric cancer are poorly understood, especially in high-prevalence countries. Based on the Global Burden of Disease Study 2019, we analyzed the incidence, death, and possible risk factors of gastric cancer in five Asian countries, in relation to year, age, sex, and sociodemographic index. The annual percentage change was calculated to estimate the trends in age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR). The highest ASIR per 100,000 person-years in 2019 was in Mongolia [44 (95% uncertainty interval (UI), 34 to 55)], while the lowest was in the Democratic People’s Republic of Korea (DPRK) [23 (95% UI, 19 to 29)]. The highest ASDR per 100,000 person-years was in Mongolia [46 (95% UI, 37 to 57)], while the lowest was in Japan [14 (95% UI, 12 to 15)]. Despite the increase in the absolute number of cases and deaths from 1990 to 2019, the ASIRs and ASDRs in all five countries decreased with time and improved sociodemographic index but increased with age. Smoking and a high-sodium diet were two possible risk factors for gastric cancer. In 2019, the proportion of age-standardized disability-adjusted life-years attributable to smoking was highest in Japan [23% (95% UI, 19 to 28%)], and the proportions attributable to a high-sodium diet were highest in China [8.8% (95% UI, 0.21 to 33%)], DPRK, and the Republic of Korea. There are substantial variations in the incidence and death of gastric cancer in the five studied Asian countries. This study may be crucial in helping policymakers to make better decisions and allocate appropriate resources.

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High‐Salt Diet‐Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet

Cited by 16 publications

References 66 publications

Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice

Effects of β-Carotin and Green Tea Powder Diets on Alleviating the Symptoms of Gouty Arthritis and Improving Gut Microbiota in C57BL/6 Mice

Kidney microbiota dysbiosis contributes to the development of hypertension

The burden and trend of gastric cancer and possible risk factors in five Asian countries from 1990 to 2019

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