High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model

Cheng, Dan; Gong, Xian Zheng; Wu, Qian; Yuan, Jie; Lv, Yuzhen; Yuan, Lin; Zhang, Xiaobing

doi:10.1021/acs.analchem.0c02277

Cited by 64 publications

(45 citation statements)

References 49 publications

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“…Further, experimental studies on molecular mechanisms have shown that adipocyte death can activate macrophages and mediate related inflammation and systemic IR ( 53 ). Adipocyte death can lead to the formation of peroxynitrite (ONOO-) ( 54 ). Among them, ONOO- further induces related inflammation and systemic IR, mediated by oxidative stress products ROS/RNS ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Chemokines in Gestational Diabetes Mellitus

Liu

Kaminga

et al. 2022

Front. Immunol.

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BackgroundStudies investigating chemokines in gestational diabetes mellitus (GDM) have yielded mixed results. The purpose of this meta-analysis was to explore whether concentrations of chemokines in patients with GDM differed from that of the controls.MethodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched Web of Science, Embase, Cochrane Library, and PubMed databases for articles, published in any language, on chemokines and GDM through August 1st, 2021. The difference in concentrations of chemokines between patients with GDM and controls was determined by a standardized mean difference (SMD) with a 95% confidence interval (CI), calculated in the meta-analysis of the eligible studies using a random-effects model with restricted maximum-likelihood estimator.ResultsSeventeen studies met the inclusion criteria for the meta-analysis. Altogether, they included nine different chemokines comparisons involving 5,158 participants (1,934 GDM patients and 3,224 controls). Results showed a significant increase of these chemokines (CCL2, CXCL1, CXCL8, CXCL9, and CXCL12) in the GDM patients compared with the controls. However, there was a significant decrease of the chemokines, CCL4, CCL11 and CXCL10, in the GDM patients compared with the controls. Moreover, subgroup analysis revealed a potential role of chemokines as biomarkers in relation to laboratory detection (different sample type and assay methods) and clinical characteristics of GDM patients (ethnicity and body mass index).ConclusionGDM is associated with several chemokines (CCL2, CCL4, CCL11, CXCL1, CXCL8, CXCL9, CXCL10 and CXCL12). Therefore, consideration of these chemokines as potential targets or biomarkers in the pathophysiology of GDM development is necessary. Notably, the information of subgroup analysis underscores the importance of exploring putative mechanisms underlying this association, in order to develop new individualized clinical and therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Chemokines in Gestational Diabetes Mellitus

Liu

Kaminga

et al. 2022

Front. Immunol.

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Section: Fluorescent Probes For Detecting Different Biomarkers In Liv...mentioning

confidence: 99%

Biomarker‐Responsive Fluorescent Probes for In‐Vivo Imaging of Liver Injury

Zhou

Peng

2022

Chemistry An Asian Journal

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Liver injury-related diseases have aroused widespread concern due to their extreme unpredictability, acute onset, and severe consequences. Nowadays, the clinical prediction and assessment of liver injury mainly focus on histopathological and serological approaches, which require a tedious process and sometimes invasive biopsy. Over the past decades, fluorescence imaging techniques have emerged for the diagnosis of diseases owing to their noninvasiveness, high fidelity and ease of operation. With regard to liver injury, fluorescent probes have been delicately designed to respond to a variety of endogenous biomolecules to precisely offer comprehensive information about the lesion site. Herein, we make a brief summary and discussion about the design strategies and applications of recently reported fluorescent biosensors responsive to a series of biomarkers involved in liver injury. The potential prospects and remaining challenges are also discussed to promote the progression in this field.

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“…Currently, various techniques for ONOO − detection have been reported, including gas chromatography mass spectrometry, 12 liquid chromatography mass spectrometry, 12 electron spin resonance 13 and fluorescence imaging. [14][15][16][17][18][19][20][21][22][23][24] Among them, fluorescence imaging techniques allow real-time monitoring of ONOO − in biomolecules and organelles noninvasively. Notably, the fast response and high-sensitivity properties of fluorescent probes make them highly desirable for detecting those RONS that have very short lifetimes.…”

Section: Introductionmentioning

confidence: 99%