High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in Japan

Nisa, Hoirun; Hirata, Akira; Kohno, Masanori; Kiyohara, Chikako; Ohnaka, Keizo

doi:10.1093/geroni/igx004.2890

Cited by 8 publications

(22 citation statements)

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“…Similar results were shown in the EPIC-Norfolk study in which the association between elevated CRP levels and all-cause mortality was apparent in all men, but only in those women with the highest levels of the CRP distribution [19]. Although CRP levels are lower in Japanese subjects compared with Western ones, CRP was an independent predictor of all-cause mortality in apparently healthy Japanese men but not women [20]. The reason for this gender diff erence needs to be elucidated.…”

Section: Discussionsupporting

confidence: 74%

Interactions between C-reactive protein and traditional risk factors in predicting mortality of older adults

Rudolf

Wall

Klaaßen-Mielke

et al. 2017

Vasa

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Summary:Background: Elevated levels of C-reactive protein (CRP) are known to be associated with cardiovascular (CV) morbidity and mortality in older adults, however, there seems to be heterogeneity of this association across subsets of individuals. We aim to assess the effects of interactions between CRP and one of the following traditional CV risk factors regarding allcause mortality in unselected elderly men and women: age, sex, body mass index, diabetes, and hypertension. Patients and methods: Three hundred and forty-four general practitioners all over Germany enrolled 6,817 unselected participants, aged 65 years or older, and performed thorough examinations, including CRP measurement at baseline (getABI study). All-cause mortality was determined in the following seven years. Cox regression analyses were done using uni-and multivariable models. Results: At baseline 4,172 participants of this cohort had a CRP value of ≤ 3 mg/L (low level CRP group), 2,645 participants had a CRP value of > 3 mg/L (high level CRP group). The unadjusted hazard ratio for all-cause death of the high level CRP group compared to the low level CRP group was 1.49 (95 % confi dence interval [95 %CI] 1.34 to 1.66). After adjustment for sex, age, education, peripheral artery disease/media sclerosis, other prior vascular events, smoking status, diabetes, systolic blood pressure, antihypertensive medication, body mass index, cholesterol, and statin use, the hazard ratio was 1.34 (95 %CI 1.20 to 1.50). Signifi cant interactions with CRP were found for sex (adjusted hazard ratio 1.38, 95 %CI 1.11 to 1.72), age (0.75, 95 %CI 0.60 to 0.94), and baseline systolic blood pressure (0.64, 95 % CI 0.51 to 0.81). The interactions of CRP with body mass index and of CRP with diabetes were not signifi cant. Conclusions: In older German adults, there seem to be effect modifi cations by age, sex, and arterial hypertension regarding the effect of CRP in the prediction of all-cause mortality.

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Section: Discussionsupporting

confidence: 74%

Interactions between C-reactive protein and traditional risk factors in predicting mortality of older adults

Rudolf

Wall

Klaaßen-Mielke

et al. 2017

Vasa

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“…It is also important to note that sex was not a modifier in our study. Some studies showed a positive association in both sexes [8,23], while significant differences appeared to exist in a single sex (mostly male [27,40,41]). However, whether males or females are at a greater risk remains controversial [8,23,41,42].…”

Section: Discussionmentioning

confidence: 99%

“…CRP, an acute-phase protein produced predominantly by hepatocytes, is a sensitive and exquisitely systemic marker of inflammation [9]. CRP has been commonly assayed for infections [10], in-hospital complications [11], prognosis influences [12] and aging-related health outcomes in clinical applications, especially cardiovascular and metabolic disease risk [13,14].Higher CRP levels have been proposed as a predictor of all-cause mortality in many [15][16][17][18][19][20][21][22][23][24][25][26] but not all studies [27].…”

Section: Introductionmentioning

confidence: 99%

Associations between C-reactive protein and all-cause mortality among oldest old adults in Chinese longevity areas: A community-based cohort study

Chen

Yang

Cao

et al. 2019

Preprint

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Background: Higher C-reactive protein (CRP) levels have been proposed as a predictor of all-cause mortality in many existing studies from multiple populations, but the association for the oldest old adults (aged 80 and older) remains unclear. Objective: To examine the association between CRP and all-cause mortality among the oldest old Chinese adults. Design: This is a prospective, community-based longitudinal cohort study with 2206 adults aged 80 years old and older with available CRP test results. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) with 95% confidential intervals (95% CIs) for all-cause mortality according to CRP quartiles, adjusting for potential confounders. Results: The median age of the participants was 93 years old, and the median CRP concentration was 1.13 mg/L at baseline. During a median follow-up period of 36.7 months, 1106 deaths were verified. After full adjustment for potential confounders, a high CRP concentration was positively associated with an increased risk of all-cause mortality. Compared with the lowest quartile, the fully adjusted HRs of the second, third, and fourth quartiles were 1.17 (95% CI: 0.94, 1.46), 1.28 (95% CI: 1.01, 1.61), and 1.50 (95% CI: 1.20, 1.87), respectively. The association of CRP with all-cause mortality was likely modified by smoking status (P = 0.011). Conclusions: Our study indicated that a high CRP concentration was likely to be a prospective factor predicting death among the oldest old adults. Future studies investigating additional factors of disease and aging processes are needed to obtain a better understanding of the mechanisms.

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“…Numerous studies have investigated the associations between hsCRP concentrations and mortality. For instance, recently, elevated hsCRP concentrations were shown to be associated with the risk of all-cause mortality in both men and women in many [6–9], but not all studies [10]. Two other prospective studies were conducted in the United States and indicated that high CRP levels were associated with significantly increased risks of all-cause and CVD-related mortality [11, 12].…”

Section: Introductionmentioning

confidence: 99%

“…However, findings regarding the effect of hsCRP concentrations on cancer mortality remain controversial. Several studies have suggested that an increased risk of cancer mortality is associated with elevated hsCRP concentrations [9, 10, 13–16]. In contrast, a recent prospective study failed to identify a similar association [17].…”

Section: Introductionmentioning

confidence: 99%

Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals

Zhong

et al. 2019

Immun Ageing

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BackgroundThe association of high-sensitivity C-reactive protein (hsCRP) with mortality is controversial. We aimed to investigate the associations of hsCRP concentrations with the risks of all-cause and cause-specific mortality and identify potential modifying factors affecting these associations among middle-aged and elderly individuals.MethodsThis community-based prospective cohort study included 14,220 participants aged 50+ years (mean age: 64.9 years) from the Health and Retirement Study. Cox proportional hazard models were employed to estimate the associations between the hsCRP concentrations and the risk of all-cause and cause-specific mortality with adjustment for sociodemographic and lifestyle factors, self-reported medical history, and other potential confounders.ResultsIn total, 1730 all-cause deaths were recorded, including 725 cardiovascular- and 417 cancer-related deaths, after an 80,572 person-year follow-up (median: 6.4 years; range: 3.6–8.1 years). The comparisons of the groups with the highest (quartile 4) and lowest (quartile 1) hsCRP concentrations revealed that the adjusted hazard ratios and 95% confidence intervals were 1.50 (1.31–1.72) for all-cause mortality, 1.44 (1.13–1.82) for cardiovascular mortality, and 1.67 (1.23–2.26) for cancer mortality. The associations between high hsCRP concentrations and the risks of all-cause, cardiovascular, and cancer mortality were similar in the men and women (P for interaction > 0.05).ConclusionsAmong middle-aged and older individuals, elevated hsCRP concentration could increase the risk of all-cause, cardiovascular, and cancer mortality in men and women.

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High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in Japan

Cited by 8 publications

References 0 publications

Interactions between C-reactive protein and traditional risk factors in predicting mortality of older adults

Interactions between C-reactive protein and traditional risk factors in predicting mortality of older adults

Associations between C-reactive protein and all-cause mortality among oldest old adults in Chinese longevity areas: A community-based cohort study

Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals

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