High‐sensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry

Deraz, Tharwat E.; Kamel, Terez Boshra; Elkerdany, Tahany A.; El-Ghazoly, Heba M.A.

doi:10.1002/ppul.21539

Cited by 40 publications

(45 citation statements)

References 24 publications

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“…The intensity of the systemic inflammation rises during exacerbations of asthma. Increased proinflammatory cytokines such as CRP, TNF-α, and IL-6 are elevated during asthma exacerbations [3,4]. Furthermore, IL-6 influences megakaryocyte ploidy and platelet volumes [34].…”

Section: Discussionmentioning

confidence: 99%

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A Decreased Mean Platelet Volume Is Associated with Stable and Exacerbated Asthma

Sun¹,

Zhang

Cao³

et al. 2014

Respiration

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Background: Systemic inflammation is related to disease progression in asthma. Activated platelets play a critical role in atherogenesis, inflammation, and atherothrombosis. The mean platelet volume (MPV) is an early marker of platelet activation. Objectives: The aim of this study is to clarify the relevance of MPV levels in patients with stable and exacerbated asthma. Methods: We investigated the peripheral blood cell count parameters, C-reactive protein (CRP), lung function parameters, and arterial blood gas in patients with asthma and control subjects. Eighty-five stable asthma patients and 85 asthmatics with exacerbations were investigated. Eighty-five controls matched for age, gender, body mass index (BMI), and smoking status were recruited. Results: Patients with exacerbated asthma had lower MPV and higher CRP levels and white blood cell (WBC) counts compared to patients with stable asthma and control subjects. Furthermore, the MPV was reduced in patients with stable asthma compared to control subjects. Negative correlations between MPV and CRP were present in stable and exacerbated asthma. Although there was no relationship between MPV and WBC count in stable asthma, there was an inverse relationship between MPV and WBC count in exacerbated asthma. Conclusions: These findings show that patients with stable asthma had a lower MPV compared to controls and the MPV levels in asthmatic patients with exacerbations were lower compared to those in patients with stable asthma. Further investigations regarding the role of MPV in asthma may be beneficial in the search for therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

“…Recent studies have demonstrated that systemic inflammation is related to disease progression in asthma [2]. Some proinflammatory cytokines such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) are increased in patients with asthma [3,4]. …”

Section: Introductionmentioning

confidence: 99%

A Decreased Mean Platelet Volume Is Associated with Stable and Exacerbated Asthma

Sun¹,

Zhang

Cao³

et al. 2014

Respiration

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“…In the pediatric population, CRP has been utilized in diseases such as Kawasaki disease [13], asthma [14], appendicitis [15], and neonatal sepsis [16]. Recently, an elevation of the CRP has been noted in children with SCD during episodes of vasoocclusive crisis [17].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the C-Reactive Protein in Predicting the Need for Antibiotics Among Febrile Inpatients with Sickle Cell Disease

Gershel¹,

Kreiner²,

Spitzer³

et al. 2015

TOIDJ

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Abstract:Objective: To determine whether the C-reactive protein (CRP) can help identify which febrile patients with sickle cell disease (SCD) require antibiotic therapy. Patients and Methods:We performed a chart review of patients with SCD (including S-S, S-C, and S-Thal) admitted to the hospital with fever [temperature >38.3 o C <2 years of age; >38.9 o C ≥2 years of age] over a thirty-month period (July 2009 -December 2011). Data extracted included temperature, age, high sensitivity CRP value, chest x-ray and culture results, and the underlying cause of fever, categorized as bacterial (antibiotics necessary) or non-bacterial (antibiotics not necessary). The Mann-Whitney U-test was then used to compare the median CRP levels of patients requiring antibiotics versus those whose illnesses did not require antibiotic treatment.Results: Fifty-four febrile patients with SCD were admitted to the hospital. Nineteen had final diagnoses that required antibiotic treatment and their median CRPs were significantly higher than the thirty-five who had diagnoses that did not meet the requirements for antibiotic treatment (100.9 mg/L vs 17.3 mg/L, p <.001). All patients who needed antibiotics had a CRP >39 mg/L. Conclusion:The current data indicate that among febrile patients with SCD, the CRP may help differentiate bacterial infections which require antibiotic treatment from other diseases for which antibiotics are not necessary. Our data suggests that there may be a level of CRP below which a bacterial etiology is unlikely.

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“…Increase in proinflammatory cytokines, such as interleukin-6 [6] and tumor necrosis factor-α [7,8] have already been described in asthmatic patients as well as elevated circulating C-reactive protein levels in non-allergic [9], and neutrophilic asthma [10]. In steroid-naive asthmatic patients Creactive protein levels negatively correlated with indices of lung function (forced expiratory volume in one second (FEV1), FEV1/ forced vital capacity and forced mid-expiratory flow) and positively with sputum eosinophil count [11].…”

Section: Introductionmentioning

confidence: 97%

Urinary Glycosaminoglycans in Asthmatic Children in Relation to Disease Control by Inhaled Corticosteroids

B¹

2015

J Allergy Ther

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High‐sensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry

Cited by 40 publications

References 24 publications

A Decreased Mean Platelet Volume Is Associated with Stable and Exacerbated Asthma

A Decreased Mean Platelet Volume Is Associated with Stable and Exacerbated Asthma

Usefulness of the C-Reactive Protein in Predicting the Need for Antibiotics Among Febrile Inpatients with Sickle Cell Disease

Urinary Glycosaminoglycans in Asthmatic Children in Relation to Disease Control by Inhaled Corticosteroids

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