High-Sensitivity C-Reactive Protein (Hs-Crp) Level and Pregnancy Outcomes in Women With Unexplained Infertility Undergoing Ovarian Stimulation With Intrauterine Insemination (Os-Iui) in a Multicenter Trial

Abstract

A total of 3,910 cycles in women R 40 years were analyzed, of which 307 utilized donor sperm and 3,603 utilized their partners sperm to conceive. In the univariate analysis, patients utilizing donor sperm were found to have similar pregnancy rates as those utilizing their partners sperm (41.0 versus 39.8%, OR: 0.95, 95% CI: 0.75-1.20). After adjusting for age, number of embryos transferred, and developmental stage of embryos, the model estimates did not vary (aOR: 1.22, 95% CI: 0.95-1.56). Similarly, the univariate analysis for live birth did not demonstrate a difference between groups (19.2 versus 17.8%, OR: 0.91, 95% CI: 0.67-1.22). However, after similar adjustment for confounders, the use of donor sperm was associated with statistically significant increased odds of live birth (aOR: 1.38, 95% CI: 1.01-1.88).CONCLUSIONS: Women R 40 years old who are unpartnered or in same sex relationships can be counseled that their odds of a live birth are slightly better than women in heterosexual relationships utilizing their partners sperm. These findings serve to further refine and individualize counseling regarding expected IVF outcome for women in this age group and social scenario.