High‐sensitivity C‐reactive protein in children at risk for coronary artery disease

Güran, Ömer; Akalın, Figen; Ayabakan, Canan; Dereli, Feyza; Haklar, Goncagül

doi:10.1111/j.1651-2227.2007.00377.x

Cited by 43 publications

(27 citation statements)

References 28 publications

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“…Previous studies have shown similar results in young overweight and obese individuals [7,8,[11][12][13][14]18]. However, the values of hs-CRP obtained in our study are higher as compared to some previous observations [11].…”

Section: Correlation Between Hscrp and Other Parameterscontrasting

confidence: 56%

“…High CRP levels also correlate well with other parameters of MS [10]. Majority of the previous studies showing raised CRP levels in obese children are from the developed countries [4][5][6][7][8][9][11][12][13][14]. The need to generate data from the developing countries is even more in view of the recent observations and recommendations for diagnosis of obesity and MS for Asian Indians [15].…”

Section: Introductionmentioning

confidence: 99%

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Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Dayal

Jain

Attri

et al. 2014

JCDR

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Context: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity. Aim:To study the relationship of hsCRP levels with various anthropometric as well as metabolic parameters in children with simple overweight and obesity. Materials and Methods:This case control study was conducted in Paediatric Endocrinology clinic of a tertiary care hospital in Northern India. Levels of hsCRP were estimated in 100 overweight and obese children (BMI between 85 th and 95 th percentiles according to age & gender specific CDC 2000 growth charts) aged between 6 and 16 years and in 100 nearly age and sex matched healthy controls. These levels were then correlated to various anthropometric (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist hip ratio, WHR; blood pressure) and biochemical (fasting blood glucose, FBG; total cholesterol, TC; high-density lipoproteincholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; very low-density lipoprotein-cholesterol, VLDL-C; triglycerides, TG) parameters.Results: Mean levels of hsCRP were significantly higher in the study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to controls. Significantly more (58% versus 10%) subjects in the study group had hsCRP (>3 mg/L). Of all the parameters studied, only BMI showed a positive correlation with hsCRP levels in the study group. Multiple logistic regression analysis for predicting outcome of high hsCRP showed positive correlation with BMI; with every 1 kg/m 2 increase in BMI, odds of high hsCRP level were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value <0.0001). Mean values of all the biochemical parameters except HDL-C were significantly higher in the study group.Conclusion: Levels of hsCRP were significantly elevated in overweight and obese children as compared to non-obese children. In addition, these patients also showed abnormalities of lipid and glucose metabolism.

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Section: Correlation Between Hscrp and Other Parameterscontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Dayal

Jain

Attri

et al. 2014

JCDR

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“…CRP, C3, C4, adiponectin and leptin were determined in serum, fibrinogen was determined in plasma and ESR was determined in whole blood. The existing literature shows that all the biomarkers analyzed in this study have been increasingly explored in studies involving children or adolescents [24][25][26][27] , suggesting that they are a valid choice for this age group.…”

Section: Biochemical Assessmentmentioning

confidence: 99%

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

et al. 2016

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Background: Overweight and obesity have been associated with a pro-inflammatory state. We aimed to assess the ability of different measures of overall and abdominal adiposity for identifying adverse levels of inflammatory and metabolic markers in adolescents. Methods: This is a cross-sectional analysis with 529 Portuguese adolescents (267 girls), mean age 14.3 ± 1.7 years. Weight, height, sitting height, waist circumference (WC), and body fat percentage (BF%) were measured; and BMI, waist-to-height ratio (WHtR), and waist-to-sitting-height ratio (WsHtR) were calculated. We measured C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR), complements C3 and C4, leptin, and adiponectin levels. Receiver operating characteristic (ROC) curves were used to estimate the ability of the adiposity measures to discriminate between low/high values of biomarkers. Results: The highest areas under the ROC curves were presented by BF% for fibrinogen and complement C3 in both sexes and for ESR, complement C4, and adiponectin only in girls; by BMI for CRP in girls and for leptin in both sexes; by WHtR for leptin in both sexes and for CRP, fibrinogen, and adiponectin only in girls; by waist circumference for CRP, fibrinogen, and complement C3 only in boys and for complement C4 in girls; and by WsHtR for complement C3 in girls; p < 0.05 for all. Conclusions: The measures that more often presented discriminatory power were, for overall adiposity, BF% in both sexes, and for abdominal adiposity, WHtR in girls and WC in boys. However, small differences in discriminatory capabilities don't allow us to clearly defend the adoption of a single measure above all others.

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“…Later studies have shown high values of hs-CRP among obese children and adolescents, indicating that in early stages there already exists a certain level of inflammation in relation to the non-obese population (5)(6)(7)(8). However, not many data are available that guarantee its utility as a marker of cardiovascular risk and diabetes in childhood (7,8).…”

Section: Introductionmentioning

confidence: 99%

“…However, not many data are available that guarantee its utility as a marker of cardiovascular risk and diabetes in childhood (7,8). Therefore, our intention is to study the levels of hs-CRP in obese children and adolescents with and without metabolic syndrome to evaluate the utility of this parameter as a method of early diagnosis of cardiovascular risk in early stages of life and to analyse whether there are variables associated with higher levels of CRP.…”

Section: Introductionmentioning

confidence: 99%

High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

Soriano‐Guillén

Hernández-García

Pita³

et al. 2008

European Journal of Endocrinology

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Objective: We intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents. Methods: The study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism. Results: Out of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8-4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5-2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels. Conclusion: The hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.European Journal of Endocrinology 159 R1-R4

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High‐sensitivity C‐reactive protein in children at risk for coronary artery disease

Cited by 43 publications

References 28 publications

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Ability of Measures of Adiposity in Identifying Adverse Levels of Inflammatory and Metabolic Markers in Adolescents

High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

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