High-Sensitivity C-Reactive Protein to HDL-C Ratio

Luo, Haorou; Kou, Tuli; Yin, Long

doi:10.1536/ihj.21-246

Cited by 13 publications

(4 citation statements)

References 42 publications

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“…Moreover, hs-CRP is found to be inversely associated with the RCT of HDL and the association between hs-CRP and coronary artery calcification score could be modified by HDL-C [ 7 , 104 ]. Therefore, hs-CRP to HDL-C ratio (CHR) is explored and has been discovered to be an independent predictor of CAD presence (adjusted OR, 1.178; 95% CI, 1.016–1.366; P = 0.03) with a specificity of 86.7%, Yoden index of 0.264 and AUC of 0.662 (95% CI, 0.606–0.719; P < 0.001) [ 91 ]. Additionally, CHR is shown closely related to Gensini score in coronary angiography ( r = 0.389; P < 0.001).…”

Section: Hdl-cholesterol–related Inflammatory Parameters In Coronary ...mentioning

confidence: 99%

Inflammation in coronary artery disease-clinical implications of novel HDL-cholesterol–related inflammatory parameters as predictors

Guo

2022

Coronary Artery Disease

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Coronary artery disease (CAD) is the leading cause of death worldwide. Inflammation and atherosclerotic plaques are the primary pathological mechanisms of CAD. Upon stimulation by deposited lipids and damaged endothelium, innate and adaptive immune cells are activated and recruited to initiate plaque development. Therefore, inflammatory cells and mediators are used to identify inflammatory risk in CAD patients. HDL-cholesterol (HDL-C) is demonstrated to have anti-inflammatory roles in atherosclerosis by interfering with plasma membrane lipid rafts of immune cells. Based on this, novel inflammatory parameters such as monocyte to HDL-C ratio are explored to improve the risk estimation of CAD prognosis. Moreover, with the advance in treatment strategies targeting the inflammatory process in atherosclerosis, identifying CAD patients with increased inflammatory risk by novel inflammatory parameters is of great importance in guiding CAD management.Therefore, this review aims to summarize the current information regarding inflammatory activation and HDL-C in atherosclerosis with a particular focus on the clinical implication of the novel HDL-C-related inflammatory parameters in CAD.

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Section: Hdl-cholesterol–related Inflammatory Parameters In Coronary ...mentioning

confidence: 99%

Inflammation in coronary artery disease-clinical implications of novel HDL-cholesterol–related inflammatory parameters as predictors

Guo

2022

Coronary Artery Disease

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“…HCHR is another combination of pro‐inflammatory and anti‐inflammatory markers. Although the association between HCHR and conditions such as coronary artery disease (CAD) [ 16 ] and contrast‐induced acute kidney injury [ 47 ] has been discussed before, no clinical studies investigate the association between HCHR and MetS yet. We found that HCHR, independent of multiple factors, is associated with MetS in women.…”

Section: Discussionmentioning

confidence: 99%

“…The inflammatory markers were calculated using the following formula [15–17]:

\mathrm{LHR}:\mathrm{lymphocyte}\ \mathrm{count}/\mathrm{HDL}\hbox{-} \mathrm{C}\ \left(\mathrm{mg}/\mathrm{dL}\right)

\mathrm{HCHR}:\mathrm{hs}\hbox{-} \mathrm{C}\mathrm{RP}\ \left(\mathrm{mg}/\mathrm{dL}\right)/\mathrm{HDL}\hbox{-} \mathrm{C}\ \left(\mathrm{mg}/\mathrm{dL}\right)

\mathrm{HCLR}:\mathrm{hs}\hbox{-} \mathrm{CRP}\ \left(\mathrm{mg}/\mathrm{dL}\right)/\mathrm{lymphocyte}\ \mathrm{count}

…”

Section: Methodsmentioning

confidence: 99%

Association of Three Novel Inflammatory Markers: Lymphocyte to HDL‐C Ratio, High‐Sensitivity C‐Reactive Protein to HDL‐C Ratio and High‐Sensitivity C‐Reactive Protein to Lymphocyte Ratio With Metabolic Syndrome

Kolahi Ahari,

Akbari,

Babaeepoor

et al. 2024

Endocrino Diabet & Metabol

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ObjectiveWe aimed to compare the association of three novel inflammatory indicators with metabolic syndrome (MetS) among Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort participants.MethodsAccording to the International Diabetes Federation (IDF) criteria, the cohort participants were divided into the MetS(+) and MetS(−) groups. The lymphocyte to high‐density lipoprotein cholesterol (HDL‐C) ratio (LHR), high‐sensitivity C‐reactive protein (hs‐CRP) to HDL‐C ratio (HCHR) and hs‐CRP to lymphocyte ratio (HCLR) were calculated and were compared between the groups. Binary logistic regression (LR) analysis was performed to find the association of the indices with the presence of MetS among men and women. Receiver‐operating characteristic (ROC) curve analysis was used to establish cut‐off values in predicting MetS for men and women. p‐Values <0.05 were considered as statistically significant.ResultsAmong a total of 8890 participants (5500 MetS(−) and 3390 MetS(+)), LHR, HCHR and HCLR were significantly higher in the MetS(+) group than in MetS(−) group (p < 0.001). In LR analysis, after adjusting for multiple cofounders, LHR remained an independent factor for the presence of MetS among men (OR: 1.254; 95% CI: 1.202–1.308; p < 0.001) and women (OR: 1.393; 95% CI: 1.340–1.448; p < 0.001). HCHR also remained an independent factor for the presence of MetS only in women (OR: 1.058; 95% CI: 1.043–1.073; p < 0.001). ROC curve analysis showed that LHR had the higher AUC for predicting MetS in both men (AUC: 0.627; 95% CI: 0.611–0.643; p < 0.001) and women (AUC: 0.683; 95% CI: 0.670, 0.696; p < 0.001).ConclusionThis suggests that among both genders, the LHR as an inexpensive and easy‐to‐access marker has a better diagnostic performance and could be a promising alternative to the traditional expensive inflammatory markers such as hs‐CRP for the evaluation of inflammation in patients with MetS.

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“…CRP/HDL-C ratio was calculated by dividing the serum concentration of CRP(mg/L) by HDL-C measured in mmol/L ( 16 ).…”

Section: Methodsmentioning

confidence: 99%

CRP/HDL–C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus

Djesevic,

Hasic,

Lepara

et al. 2023

Acta Inform Med

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Background: Metabolic syndrome (MetS) denotes a cluster of co-occurring medical conditions associated with regulating hyperglycemia and acute cardiovascular events and complications. The escalating frequency of MetS among individuals afflicted with type 2 diabetes mellitus (T2DM) underscores its burgeoning significance as a critical public health concern and a complex clinical conundrum. Timely identification is imperative to avert the expedited progression of diabetic complications. Objective: To investigate the role of CRP/HDL-C and Monocyte/HDL ratios in predicting MetS in T2DM individuals. Methods: The study was designed as a two-year prospective study and included 80 T2DM patients divided into MetS and non-MetS groups based on MetS development over two years. The patients’ serums were analyzed for complete blood count parameters, lipid profile, and C-reactive protein (CRP). Based on the laboratory test results, Monocyte/HDL-C and CRP/HDL-C ratios were calculated and analyzed. The receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine prognostic accuracy. Results: Monocyte/HDL-C ratio and CRP/HDL-C ratio were significantly higher in MetS-T2DM2 than in nonMetS-T2DM (p=0.003 and p=0.029, respectively). The results of ROC curve analysis have shown that the CRP/HDL-C ratio (AUC of 0.695) and Monocytes/HDL-C ratio (AUC of 0.645) can serve as good predictors of MetS in T2DM patients. Conclusion: This study confirms the reliability of the Monocytes/HDL-C and CRP/HDL-C ratios as novel, simple, low-cost, and valuable predictors of MetS development in T2DM.

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High-Sensitivity C-Reactive Protein to HDL-C Ratio

Cited by 13 publications

References 42 publications

Inflammation in coronary artery disease-clinical implications of novel HDL-cholesterol–related inflammatory parameters as predictors

Inflammation in coronary artery disease-clinical implications of novel HDL-cholesterol–related inflammatory parameters as predictors

Association of Three Novel Inflammatory Markers: Lymphocyte to HDL‐C Ratio, High‐Sensitivity C‐Reactive Protein to HDL‐C Ratio and High‐Sensitivity C‐Reactive Protein to Lymphocyte Ratio With Metabolic Syndrome

CRP/HDL–C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus

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