High serum adiponectin is associated with anemia development in chronic kidney disease: The results from the KNOW-CKD study

High AdiponectinHormone Modulation ofBlood Erythroid Parameters and its Relation with Erythropoietin in Patients with Diabetic Nephropathy

“…It is reported that suchchange in adiponectin level is associated with loss of energy and protein and increased fluid volume in this group of patients [2,3]. Severalstudies [1,9]suggest a negative correlation between adiponectinand growth of hematopoietic stem cells. According to some studies, it might also regulate mass of bone and mesenchymal stem cell migration in the bone marrow.…”

“…Other causes might includeoverproduction of adiponectin in adipose tissue by amelioration of glomerular hypertrophy, through activation of adenosine 5'-monophosphate-activated protein kinase by AdipoR1 and activation of peroxisome proliferator-activated receptor (PPAR)-α signaling pathway by AdipoR2 (7). Several single nucleotide polymorphisms in the adiponectin gene are associated with increased risk of the development of diabetic nephropathy at ESRD [1,11]. A study by Zha et al, [12]is in consistencewith the results of the presentstudyin terms of supportingthe notion that the association of adiponectin with diabetic nephropathy may be due to the expression and regulation by specific factors that regulate adiponectin gene (AdipoQ) transcription,such asCCAAT-enhancer binding protein A, forkhead box O1 (FOXO1), and specificity protein 1.…”

“…Erythroid disorders, including anemia, are mostly encountered in the general clinical setting. Anemia is affected by hematopoietic growth factor erythropoietin (EPO) [1,2]. Some people have anemia that is unrelated to nutrient deficiency or chronic metabolic diseases, but other factorsmay contribute to cause anemia [3].…”

“…According to some studies, it might also regulate mass of bone and mesenchymal stem cell migration in the bone marrow. Therefore, it probablyindirectly enhances erythropoiesis process rather than having a direct effect on erythrocytes [1,9]. In chronic kidney disease (CKD) and diabetic patients, level of circulating adiponectin is paradoxically fluctuated and the role of adiponectin is complex to realize [1].…”

“…Therefore, it probablyindirectly enhances erythropoiesis process rather than having a direct effect on erythrocytes [1,9]. In chronic kidney disease (CKD) and diabetic patients, level of circulating adiponectin is paradoxically fluctuated and the role of adiponectin is complex to realize [1]. Therefore, we aimed to evaluate adiponectin level and blood erythroid parametersand determine whether adiponectinis associated with anaemia and Hb concentration in diabetic nephropathy patients, since such an associationseems to be unclear till now.…”