High serum concentrations of dimeric inhibins A and B in normal newborn girls

Bergadá, Ignacio; Ballerini, Gabriela M.; Ayuso, S; Groome, Nigel P.; Bergadá, C; Campo, Stella

doi:10.1016/s0015-0282(01)02965-x

Cited by 14 publications

(7 citation statements)

References 6 publications

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“…Interestingly, the median serum value of inhibin B in our study was higher than reported for prepubertal children and close to values seen in the follicular phase of the menstrual cycle in adult women (23). However, serum levels of inhibin B are considerably lower in girls than found in comparable studies of boys (the median in females was less than half of that in boys) (7,11,24).…”

Section: Discussionsupporting

confidence: 63%

“…In girls, FSH remains high until about 4 yr of age (4,8,9). Little is known about inhibins A and B in infant girls, because only very few and small studies exist (7,10,11). Inhibin B is the principal form of inhibin secreted in adult women in the follicular phase by the granulosa cells of the small antral follicles, whereas inhibin A is produced by the leading follicle at the time of ovulation and by the corpus luteum (12,13).…”

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confidence: 99%

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Inhibin A, Inhibin B, Follicle-Stimulating Hormone, Luteinizing Hormone, Estradiol, and Sex Hormone-Binding Globulin Levels in 473 Healthy Infant Girls

Chellakooty

Schmidt

Haavisto

et al. 2003

The Journal of Clinical Endocrinology & Metabolism

148

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The early postnatal regulation of reproductive hormones seems to be more complex in girls than in boys. The aim of this study was to describe inhibins A and B, FSH, LH, estradiol, and SHBG in a large prospective cohort of 473 unselected, healthy, 3-month-old girls. In full term, appropriate-for- gestational-age girls (n = 355) hormones showed a marked interindividual variation, with concentrations up to pubertal values [medians (95% confidence intervals): inhibin B, 82 pg/ml (<20-175); FSH, 3.8 IU/liter (1.2-18.8); LH, 0.07 IU/liter (<0.05-1.07); estradiol, 31 pM (<18-83); SHBG, 137 nM (72-260)]. In 38%, FSH levels exceeded 4.5 IU/liter. Weight at 3 months had significant inverse relationships with estradiol and SHBG (P = 0.048 and P = 0.001, respectively). Gestational age was negatively correlated to estradiol (P = 0.001), with a similar trend for LH, FSH, and inhibin B. Inhibin B was higher in premature girls [126 pg/ml (<20-265)] than in term [80 pg/ml (<20-181), P = 0.002] and postmature girls [59 pg/ml (<20-152), P = 0.012]. Likewise, estradiol levels in prematures were higher than in mature girls [51 pM (<18-128) vs. 31 pM (<18-85), P = 0.009]. Estradiol was also higher in small-for-gestational-age than in appropriate-for-gestational-age girls (P = 0.046), with inhibin B and LH, but not FSH, showing a similar trend. In conclusion, reproductive hormones showed a large variation, and concentrations corresponded to those observed in puberty. Our findings support the concept of a minipuberty in infant girls similar to that in boys.

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Section: Discussionsupporting

confidence: 63%

mentioning

confidence: 99%

Inhibin A, Inhibin B, Follicle-Stimulating Hormone, Luteinizing Hormone, Estradiol, and Sex Hormone-Binding Globulin Levels in 473 Healthy Infant Girls

Chellakooty

Schmidt

Haavisto

et al. 2003

The Journal of Clinical Endocrinology & Metabolism

148

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“…At D7 and M3, InhB levels were negatively correlated with FSH in the whole group, suggesting that InhB suppresses FSH secretion already in infancy, and consequently, higher InhB levels in boys than in girls probably also result in a sex difference in FSH levels. Some previous studies have found no association between FSH and InhB in prepubertal boys or girls, whereas a negative correlation already at 3 months of age has been reported in boys and girls . The changing patterns of pituitary and gonadal hormone levels according to PM and chronological age complicate the evaluation of the associations between separate hormones, which might explain the discrepancy in previous reports regarding the associations between FSH and InhB in infancy.…”

Section: Discussionmentioning

confidence: 80%

Sexual dimorphism in postnatal gonadotrophin levels in infancy reflects diverse maturation of the ovarian and testicular hormone synthesis

Kuiri-Hänninen

Dunkel

Sankilampi

2018

Clinical Endocrinology

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“…In infant boys inhibin B levels exceed levels in adult men, 10 but in infant girls, although inhibin A and inhibin B are detectable, their levels remain lower than in pubertal girls. 8,11 There is also a sexual dimorphism in the pubertal increase in inhibin B levels. In males, most authors have found a significant elevation at 9 to 10 years of age when pubertal stage 2 is achieved.…”

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confidence: 99%

Inhibin B in Pubertal Development and Pubertal Disorders

Lahlou¹,

Roger²

2004

Semin Reprod Med

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The inhibin B pubertal surge is a prominent signal of gonadal maturation in females as well as in males. In boys, it denotes the final functional maturation of Sertoli cells, which is accompanied by a progressive suppression of antimüllerian hormone production. In girls it reflects the initial recruitment of preantral follicles and their evolution to the antral stage. In both the prepubertal quiescent phase and the active peripubertal phase there is a striking sexual dimorphism, inhibin B levels being significantly higher in boys than in girls, in contrast to follicle-stimulating hormone (FSH) levels. Determining inhibin B levels together with FSH levels is of considerable help for diagnosing disorders of pubertal development. In girls with central precocious precocity, inhibin B levels are in accordance with the clinical stage of maturation, by contrast to normal or low levels in the McCune-Albright syndrome. In boys with delayed puberty, inhibin B levels are very low in congenital defects of the gonadotropin-releasing hormone-FSH-testis axis, but they are normal or intermediate in constitutional delayed puberty. Together with antimüllerian hormone, inhibin B is a useful marker of the presence of Sertoli cells in bilateral cryptorchidism and in the androgen insensitivity syndrome. In addition, inhibin B measurement, together with that of inhibin A, is helpful for the diagnosis and follow-up of inhibin-secreting tumors: granulosa cell tumors in girls and Sertoli cell tumors of the Peutz-Jeghers syndrome in boys. In conclusion, inhibin determination is an essential tool in the assessment of physiological development as well as in the management of pubertal disorders.

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High serum concentrations of dimeric inhibins A and B in normal newborn girls

Cited by 14 publications

References 6 publications

Inhibin A, Inhibin B, Follicle-Stimulating Hormone, Luteinizing Hormone, Estradiol, and Sex Hormone-Binding Globulin Levels in 473 Healthy Infant Girls

Inhibin A, Inhibin B, Follicle-Stimulating Hormone, Luteinizing Hormone, Estradiol, and Sex Hormone-Binding Globulin Levels in 473 Healthy Infant Girls

Sexual dimorphism in postnatal gonadotrophin levels in infancy reflects diverse maturation of the ovarian and testicular hormone synthesis

Inhibin B in Pubertal Development and Pubertal Disorders

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