High serum fibroblast growth factor 21 is associated with inferior hepatocellular carcinoma survival: A prospective cohort study

Liu, Zhaoyan; Luo, Yan; Fang, Aiping; Wusiman, Maierhaba; He, Tong-Tong; Liu, Xiao-Zhan; Yishake, Dinuerguli; Chen, Si; Lu, Xiaoting; Zhang, Yaojun; Zhu, Huilian

doi:10.1111/liv.15100

Cited by 12 publications

(9 citation statements)

References 27 publications

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“…This aberrant expression appears to be more favorable for FGF21's binding. Consistently, both liver and serum levels of FGF21 were upregulated in patients with hepatitis, cirrhosis, and liver tumors, and associated with a significantly decreased survival rate in patients with inferior hepatocellular carcinoma 90 . For the carcinogen-induced HCC animal model, increased FGF21 levels were observed in the early and middle stages of tumorigenesis, and also in normal hepatocytes adjacent to the tumor foci, while sharply diminished once cells progressed to malignancy.…”

Section: Fgf21 Is a Promising Biomarker With Pleiotropic Activities I...mentioning

confidence: 67%

Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers

Sui

Chen

2022

Int. J. Biol. Sci.

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Fibroblast growth factor (FGF) 21 is one of the FGF members with special endocrine properties. In the last twenty years, it has attracted intense research and development for its physiological functions that respond to dietary manipulation, pharmacological benefits of improving the macronutrient metabolism, and clinical values as a biomarker of various human diseases. Generally, FGF21 can be produced by major metabolic organs, but only the subgroup from the liver shows canonical endocrine properties, which emphasizes the special value of delineating the unique secretory and functional characteristics of hepatic FGF21. There has been a growth in literature to address the extra-hepatic activities of FGF21, and many striking findings have therefore been published. Yet, they are fragmented and scattered, and controversies are raised from divergent findings. For this reason, there is a need for a systematic and critical evaluation of current research in this aspect. In this review, we focus on the current knowledge about the molecular biology of endocrine FGF21, especially present details on the regulation of circulating levels of FGF21. We also emphasize its emerging roles in inter-organ crosstalk and cancer development.

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Section: Fgf21 Is a Promising Biomarker With Pleiotropic Activities I...mentioning

confidence: 67%

Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers

Sui

Chen

2022

Int. J. Biol. Sci.

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“…To the best of our knowledge, few studies reported an association between HCC and the expression of FGF21. FGF21 is induced by liver injury and stress and can be a prognostic biomarker to monitor the carcinogenesis of the liver and established as an early diagnostic biomarker for HCC (23)(24)(25). A study reported that higher levels of FGF21 related to worse survival in HCC patients (23).…”

Section: Fgf In Hccmentioning

confidence: 99%

“…FGF21 is induced by liver injury and stress and can be a prognostic biomarker to monitor the carcinogenesis of the liver and established as an early diagnostic biomarker for HCC (23)(24)(25). A study reported that higher levels of FGF21 related to worse survival in HCC patients (23). Finn et al discovered that higher levels of FGF21 associated with shorter overall survival in HCC patients regardless of treatment (97) and they suggested that FGF21 might be an independent prognostic factor for overall survival in HCC (97).…”

Section: Fgf In Hccmentioning

confidence: 99%

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The role of FGF21 and its analogs on liver associated diseases

et al. 2022

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Fibroblast growth factor 21 (FGF21), a member of fibroblast growth factor family, is a hormone-like growth factor that is synthesized mainly in the liver and adipose tissue. FGF21 regulates lipid and glucose metabolism and has substantial roles in decreasing lipogenesis and increasing hepatic insulin sensitivity which causing lipid profile improvement. FGF21 genetic variations also affect nutritional and addictive behaviors such as smoking and alcohol consumption and eating sweets. The role of FGF21 in metabolic associated diseases like diabetes mellitus had been confirmed previously. Recently, several studies have demonstrated a correlation between FGF21 and liver diseases. Non-alcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease worldwide. NAFLD has a wide range from simple steatosis to steatohepatitis with or without fibrosis and cirrhosis. Elevated serum levels of FGF21 associated with NAFLD and its pathogenesis. Alcoholic fatty liver disease (AFLD), another condition that cause liver injury, significantly increased FGF21 levels as a protective factor; FGF21 can reverse the progression of AFLD and can be a potential therapeutic agent for it. Also, NAFLD and AFLD are the most important risk factors for hepatocellular carcinoma (HCC) which is the fourth deadliest cancer in the world. Several studies showed that lack of FGF21 induced oncogenic condition and worsened HCC. In this review article, we intend to discuss different aspects of FGF21 in NAFLD, AFLD and HCC; including the role of FGF21 in pathophysiology of these conditions, the effects of FGF21 mutations, the possible use of the FGF21 as a biomarker in different stages of these diseases, as well as the usage of FGF21 and its analog molecules in the treatment of these diseases.

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“…Due to its association with obesity and liver injury, the high levels of circulating FGF21 are often linked to different dysfunctional metabolic processes [ 24 ]. About this, higher serum FGF21 levels have been also associated with worse survival in hepatocellular carcinoma (HCC) patients [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Table Grape Use on Serum Levels of Omega-3 Index and Liver Function: A Randomized Controlled Clinical Trial

et al. 2022

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This clinical trial was aimed to investigate the effects of fresh table grape intake on the serum levels of the Omega-3 index, defined as the sum of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) levels. Forty consecutive healthy subjects were randomly assigned to the control group, receiving only dietary recommendations, and the grape group receiving a daily dose of 5 g of fresh table grape per kg of body weight, for 21 days. Compared with baseline, the grape treatment produced no significant difference in the serum levels of glucose, liver transaminase, and triglycerides, with the exception of cholesterol value, which was significantly reduced in both control and grape group (180.5 ± 20.32 vs. 196.1 ± 30.0 and 181.4 ± 21.9 vs. 194.3 ± 37.5, respectively). After 4 weeks from the end of grape treatment, the analysis of single fatty acids showed a significant increase in oleic acid content (14.15 ± 1.8 vs. 12.85± 1.6, p < 0.05) and a significant induction of the Omega-3 index (8.23 ± 1.9 vs. 6.09 ± 1.2, p < 0.05), associated with increased serum levels of adiponectin (24.09 ± 1.08 vs. 8.8 ± 0.7, p < 0.001). In contrast, the expression of fibroblast growth factor 21 (FGF21), a molecule associated with metabolic syndrome and liver disease, was significantly reduced (37.9 ± 6.8 vs. 107.8 ± 10.1, p < 0.001). The data suggest that the intake of fresh grape improves the Omega-3 index in the serum and exerts beneficial effects on liver function through the overexpression of adiponectin and the reduction in FGF21 levels.

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High serum fibroblast growth factor 21 is associated with inferior hepatocellular carcinoma survival: A prospective cohort study

Cited by 12 publications

References 27 publications

Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers

Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers

The role of FGF21 and its analogs on liver associated diseases

Beneficial Effects of Table Grape Use on Serum Levels of Omega-3 Index and Liver Function: A Randomized Controlled Clinical Trial

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