High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

Cho, Eun Hee; Cho, Keun Hyok; Lee, Hyang Ah; Kim, Sang Wook

doi:10.3346/jkms.2013.28.10.1496

Cited by 32 publications

(32 citation statements)

References 17 publications

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“…Fodor et al indicated that serum OPN levels greater than 9.47 mg/L were the threshold for diagnosing osteoporosis at the lumbar spine using a R&D systems Kit [10]. Cho et al also measured serum OPN levels in 409 postmenopausal women by using a R&D Kit, and the mean OPN levels appeared to be relatively high in all the participants compared with the published data by Fodor (43.6 ± 25.9 mg/L versus 13.17 ± 12.63 mg/L) [9,10]. Therefore, it should be emphasized that serum or plasma OPN levels measured even with the same detection system could only be used for reference to each other.…”

Section: Discussionmentioning

confidence: 87%

“…In a word, OPN is a key regulator of RANKL-induced osteoclastogenesis under the condition of ovariectomy and unloading. Recent evidences from Korea [9], Romania [10], and Taiwan [11] indicate that high serum OPN levels are correlated with low BMD and increased bone turnover levels in Postmenopausal women. Based on above studies in rodents and humans, we speculated that OPN may be a pivotal element for bone mass changes in postmenopausal women in Southern China.…”

Section: Introductionmentioning

confidence: 98%

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Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women

Wei

Huang

Tan

et al. 2015

Scandinavian Journal of Clinical and Laboratory Investigation

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Osteopontin (OPN) is an extracellular matrix protein that is expressed in bone cells such as osteoblast and osteocytes and associated with bone turnover and bone mineral density (BMD) in postmenopausal women. Here, we aimed to investigate the relationship between circulating OPN levels and BMD in postmenopausal women in Southern China. A total of 362 postmenopausal women were consecutively recruited into this study from 2011-2013. Serum levels of OPN, receptor activator of nuclear factor kappa B (NF-κB) ligand (RANKL), and bone turnover markers were analyzed. BMD was measured by dual energy X-ray absorptiometry. Osteoporosis and osteopenia were diagnosed according to the World Health Organization criteria. Serum OPN levels were remarkably higher in the osteoporotic group than those in the osteopenic and normal groups (all p < 0.001). The cut-off value of OPN for diagnosing postmenopausal osteoporosis was 10.1 ng/mL, which had a sensitivity of 89.5%, a specificity of 70.8%, and an area under curve of 0.953. Serum OPN was negatively correlated with parathyroid hormone (PTH), lumbar spine BMD, and femoral neck BMD (r = -0.25, p = 0.004; r = -0.66, p < 0.001; r = -0.28, p = 0.001; respectively) and positively associated with type I procollagen amino-terminal propeptide (PINP), carboxy-terminal cross-linking telopeptide of type I collagen (CTX), and RANKL (r = 0.20, p = 0.020; r = 0.17, p = 0.036; r = 0.19, p = 0.028, respectively) in the osteoporotic group. In multiple regression analyses, lumbar spine BMD, PTH and RANKL were the predictors for serum OPN levels. In conclusion, OPN serum levels are negatively related to BMD and positively correlated with bone turnover levels in this group of Chinese postmenopausal women.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 98%

Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women

Wei

Huang

Tan

et al. 2015

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Serum OPN levels confer the susceptibility and prognosis of ischemic stroke in Chinese patients [23]. In bones, OPN is produced by osteoblasts and osteoclasts, and involved in bone resorption and formation [24]. It has been suggested that OPN may facilitate the adhesion (or detachment) of the osteoclast to the bone surface and act as a signaling molecule or a scaffold in normal bone metabolism and turnover [22,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, OPN is reportedly involved in bone desorption and formation [9]. Recent study shows that high serum OPN level is associated with a low bone mineral density in postmenopausal women [10]. OPN also well known as a molecule that consistently colocalizes with ectopic calcification and is over-expressed in the hyperostotic spinal lesions [11].…”

Section: Introductionmentioning

confidence: 99%

OPN Polymorphism is Associated with the Susceptibility to Cervical Spondylotic Myelopathy and its Outcome After Anterior Cervical Corpectomy and Fusion

Guo

et al. 2014

Cell Physiol Biochem

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Background: Osteopontin (OPN) is reportedly involved in bone desorption, formation and ectopic calcification. We sought to investigate the role of OPN gene polymorphism in the susceptibility to Cervical spondylotic myelopathy (CSM) and in predicting the outcome anterior cervical corpectomy and fusion (ACF). Methods: A total of 187 patients diagnosed with CSM and 233 sex and age matched healthy controls were enrolled in this study. All CSM patients received ACF and were followed up for 24 months. The polymorphisms of OPN gene at 3 loci, namely, -156 G>GG, -443 C>T and -66T>G were determined. Results: The -66T>G genotype was significantly different between CSM patients and controls. Compared to the -66TT carriers, the -66GG genotype carriers had a higher risk for developing CSM (adjusted Odd Ratio=2.58, adjusted P=0.001). In contrast, the genotype distributions of the -156G/GG and -443C/T loci were not significantly different between the CSM and control groups. OPN gene polymorphism did not determine the pre-operative severity of CSM patients, but the -66T>G genotype was significantly associated with the clinical outcome of CSM after ACF treatment. The -66T>G did not affect the serum OPN level, but affect the local expressions of OPN and a serious of key inflammatory factors in the intervertebral disc samples. Conclusion: Our study shows the OPN -66T>G genetic polymorphism contributes to patients' susceptibility to CSM and could be indicative of the outcome of ACF surgery.

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“…Osteopontin is an abundant non-collagenous protein in bone matrix and participates in bone resorption and formation [31]. High OPN protein levels have been suggested as a risk factor for low bone mineral density in postmenopausal women [32].…”

Section: Discussionmentioning

confidence: 99%

Osteopontin, Bone Morphogenetic Protein-4, and Vitamin D Receptor Gene Polymorphisms in the Susceptibility and Clinical Severity of Spinal Tuberculosis

Wang

Xie

et al. 2017

Cell Physiol Biochem

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Background/Aims: Spinal tuberculosis (TB) is a common and dangerous form of extrapulmonary TB with unclear mechanisms in its occurrence and progression. This study investigated the clinical significances of bone morphogenetic protein-4 (BMP-4), osteopontin (OPN), and vitamin D receptor (VDR) gene polymorphism, mRNA and protein expression in spinal TB patients. Methods: BMP-4 and OPN gene polymorphisms were detected by direct DNA sequencing, while VDR-FokI polymorphisms were analyzed using PCR-RFLP. mRNA and protein expression was measured using real-time PCR and Western blot, respectively. Results: A significant lower frequency of TT genotype and T allele at 6007C>T polymorphism in BMP-4 gene; higher frequency of GG genotype and G allele at -66T>G polymorphism in OPN gene, and higher frequency of the ff genotype and f allele at the VDR-FokI polymorphism were observed in patients with spinal TB compared to controls. TT genotype of 6007C>T polymorphism correlated with a lower BMP-4 mRNA and protein expression, -66GG genotype correlated with a high OPN mRNA and protein expression, and ff genotype correlated with the lower VDR mRNA and protein levels in the intervertebral disc tissues. The TT genotype and low BMP-4 gene expression; the -66GG genotype and high OPN gene expression; and the ff genotype and low VDR gene expression significantly correlated with the clinical severity of spinal TB. Conclusion: The 6007C>T polymorphism of BMP-4, -66T>G polymorphism of OPN, and VDR-FokI polymorphism are the susceptible factors of spinal TB and indicators of the clinical severity. These three genes may collaborate in the development of spinal TB.

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High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women

Cited by 32 publications

References 17 publications

Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women

Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women

OPN Polymorphism is Associated with the Susceptibility to Cervical Spondylotic Myelopathy and its Outcome After Anterior Cervical Corpectomy and Fusion

Osteopontin, Bone Morphogenetic Protein-4, and Vitamin D Receptor Gene Polymorphisms in the Susceptibility and Clinical Severity of Spinal Tuberculosis

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