High SLC7A11 expression in normal skin of melanoma patients

Galván, Ismael; Inácio, Ângela; Dañino, María; Corbí-Llopis, R.; Monserrat, María T.; Bernabéu‐Wittel, José

doi:10.1016/j.canep.2019.101582

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…Or ces antigènes sont majoritairement issus des propriétés intrinsèques aux mélanocytes qui se regroupent en une fonction principale qui est la production de mélanosome. De plus, plusieurs facteurs essentiels à la production des mélanosomes, tels que MITF ou SLC7A11, ont été impliqué dans la mélanomagénèse et s'avère donc être des cibles potentielles spécifiques du mélanome (Galván et al, 2019;Levy et al, 2006;Moon et al, 2017).…”

Section: I6 Les Lysosomes Et Les Mécanismes De Réparation Membranaire...unclassified

Ultrarapid lytic granule release from CTLs activates Ca ²⁺ -dependent synaptic resistance pathways in melanoma cells

et al. 2022

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Human cytotoxic T lymphocytes (CTLs) exhibit ultrarapid lytic granule secretion, but whether melanoma cells mobilize defense mechanisms with commensurate rapidity remains unknown. We used single-cell time-lapse microscopy to offer high spatiotemporal resolution analyses of subcellular events in melanoma cells upon CTL attack. Target cell perforation initiated an intracellular Ca 2+ wave that propagated outward from the synapse within milliseconds and triggered lysosomal mobilization to the synapse, facilitating membrane repair and conferring resistance to CTL induced cytotoxicity. Inhibition of Ca 2+ flux and silencing of synaptotagmin VII limited synaptic lysosomal exposure and enhanced cytotoxicity. Multiplexed immunohistochemistry of patient melanoma nodules combined with automated image analysis showed that melanoma cells facing CD8 + CTLs in the tumor periphery or peritumoral area exhibited significant lysosomal enrichment. Our results identified synaptic Ca 2+ entry as the definitive trigger for lysosomal deployment to the synapse upon CTL attack and highlighted an unpredicted defensive topology of lysosome distribution in melanoma nodules.

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Section: I6 Les Lysosomes Et Les Mécanismes De Réparation Membranaire...unclassified

Ultrarapid lytic granule release from CTLs activates Ca ²⁺ -dependent synaptic resistance pathways in melanoma cells

et al. 2022

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“…The expression of SLC7A11 , which encodes the cystine/glutamate antiporter Xc - to mediate cystine uptake, is significantly higher in melanoma tissues compared to the controls. The increased cystine uptake elevates the intracellular cysteine level to facilitate the synthesis of glutathione (GSH) and improve the antioxidant capability and viability of melanoma cells ( 65 ). In addition to the abovementioned glutamine, serine, and cystine, the metabolism of branched-chain amino acids (BCAAs) also demonstrates pathogenic significance in melanoma.…”

Section: Reprogramming Of Amino Acid Metabolism In Melanomamentioning

confidence: 99%

Metabolic rewiring directs melanoma immunology

et al. 2022

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Melanoma results from the malignant transformation of melanocytes and accounts for the most lethal type of skin cancers. In the pathogenesis of melanoma, disordered metabolism is a hallmark characteristic with multiple metabolic paradigms involved in, e.g., glycolysis, lipid metabolism, amino acid metabolism, oxidative phosphorylation, and autophagy. Under the driving forces of oncogenic mutations, melanoma metabolism is rewired to provide not only building bricks for macromolecule synthesis and sufficient energy for rapid proliferation and metastasis but also various metabolic intermediates for signal pathway transduction. Of note, metabolic alterations in tumor orchestrate tumor immunology by affecting the functions of surrounding immune cells, thereby interfering with their antitumor capacity, in addition to the direct influence on tumor cell intrinsic biological activities. In this review, we first introduced the epidemiology, clinical characteristics, and treatment proceedings of melanoma. Then, the components of the tumor microenvironment, especially different populations of immune cells and their roles in antitumor immunity, were reviewed. Sequentially, how metabolic rewiring contributes to tumor cell malignant behaviors in melanoma pathogenesis was discussed. Following this, the proceedings of metabolism- and metabolic intermediate-regulated tumor immunology were comprehensively dissertated. Finally, we summarized currently available drugs that can be employed to target metabolism to intervene tumor immunology and modulate immunotherapy.

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“… 85 At the same time, clinical data showed that among patients with melanin, the expression of cystine associated transporters SLC7A11 and SLC3A2 was negatively correlated with the number of CD8+T cells, IFN-γ expression level and patient prognosis. 86 Despite recently targeting lung cancer, the relationship between T cell and ferroptosis is uncertain. However, it is not difficult to find that T cell promotes the ferroptosis of lung cancer cell is a potential treatment and can enhance the treatment efficiency of immunotherapy.…”

Section: The Role Of Ferroptosis In Lung Cancermentioning

confidence: 99%

Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

Chen¹,

Zhang²,

Jiao³

et al. 2021

JIR

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Lung cancer is characterized by high morbidity and mortality rates, and its occurrence is associated with many types of cell death. As a new form of regulated cell death, ferroptosis is an iron- dependent pattern of cell death and characterized by lethal accumulation of lipid-based reactive oxygen species (ROS), which is different from apoptosis, necrosis and autophagy at both the morphological and biochemical levels. It plays an important role in the development of lung cancer and induction of ferroptosis in lung cancer cells has become a new strategy for anti- lung cancer treatment. However, a few reviews summarized ferroptosis and its role in lung cancer has not been elucidated, and the precise mechanism of ferroptosis modeling lung cancer has not yet been revealed till date. Herein, we review the latest literature on the process of ferroptosis regarding lung cancer, including basic molecular or biology mechanistic studies both in vivo and in vitro, as well as human studies with a more translational or clinical approach. This review provides a practical, concise and updated outline on the mechanisms and therapeutic strategies in lung cancer with ferroptosis alterations. Looking ahead, further studies are required to uncover the possible modulatory relationship between ferroptosis and lung cancer.

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High SLC7A11 expression in normal skin of melanoma patients

Cited by 14 publications

References 36 publications

Ultrarapid lytic granule release from CTLs activates Ca ²⁺ -dependent synaptic resistance pathways in melanoma cells

Ultrarapid lytic granule release from CTLs activates Ca ²⁺ -dependent synaptic resistance pathways in melanoma cells

Metabolic rewiring directs melanoma immunology

Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

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High SLC7A11 expression in normal skin of melanoma patients

Cited by 14 publications

References 36 publications

Ultrarapid lytic granule release from CTLs activates Ca 2+ -dependent synaptic resistance pathways in melanoma cells

Ultrarapid lytic granule release from CTLs activates Ca 2+ -dependent synaptic resistance pathways in melanoma cells

Metabolic rewiring directs melanoma immunology

Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

Contact Info

Product

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Ultrarapid lytic granule release from CTLs activates Ca ²⁺ -dependent synaptic resistance pathways in melanoma cells

Ultrarapid lytic granule release from CTLs activates Ca ²⁺ -dependent synaptic resistance pathways in melanoma cells