High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses

Frings‐Meuthen, Petra; Buehlmeier, Judith; Baecker, Natalie; Stehle, Peter; Fimmers, Rolf; May, Francisca; Kluge, Goetz; Heer, Martina

doi:10.1152/japplphysiol.00454.2011

Cited by 37 publications

(30 citation statements)

References 62 publications

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“…As well, there is evidence that there are adverse effects of sodium chloride in the aging population. A high sodium diet will exacerbate disuse-induced bone and muscle loss during immobilization by increasing bone resorption and protein wasting [33]. Excess dietary sodium has been shown to result in hypertension and osteoporosis in women [34, 35].…”

Section: Chronic Acidosis and Bone Diseasementioning

confidence: 99%

The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?

Schwalfenberg

2012

Journal of Environmental and Public Health

120

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This review looks at the role of an alkaline diet in health. Pubmed was searched looking for articles on pH, potential renal acid loads, bone health, muscle, growth hormone, back pain, vitamin D and chemotherapy. Many books written in the lay literature on the alkaline diet were also reviewed and evaluated in light of the published medical literature. There may be some value in considering an alkaline diet in reducing morbidity and mortality from chronic diseases and further studies are warranted in this area of medicine.

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Section: Chronic Acidosis and Bone Diseasementioning

confidence: 99%

The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?

Schwalfenberg

2012

Journal of Environmental and Public Health

120

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“…As the resorbing cells, osteoclasts, need an acidic environment to be activated [81,82,83], the acidosis that results from high sodium chloride intake might cause increased bone resorption as shown by bone resorption markers [80]. This effect is exacerbated when bone-resorbing mechanisms are already activated because of the immobilization in bed rest [84]. Bone formation, on the other hand, does not seem to be affected by acidosis, as shown by bone formation markers [84].…”

Section: Bone Loss Countermeasuresmentioning

confidence: 99%

“…This effect is exacerbated when bone-resorbing mechanisms are already activated because of the immobilization in bed rest [84]. Bone formation, on the other hand, does not seem to be affected by acidosis, as shown by bone formation markers [84]. How much high sodium chloride intake affects bone turnover during space flight is currently being examined on the ISS in controlled studies, by comparing bone turnover in phases of low and high sodium intake.…”

Section: Bone Loss Countermeasuresmentioning

confidence: 99%

Space Flight Calcium: Implications for Astronaut Health, Spacecraft Operations, and Earth

et al. 2012

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The space flight environment is known to induce bone loss and, subsequently, calcium loss. The longer the mission, generally the more bone and calcium are lost. This review provides a history of bone and calcium studies related to space flight and highlights issues related to calcium excretion that the space program must consider so that urine can be recycled. It also discusses a novel technique using natural stable isotopes of calcium that will be helpful in the future to determine calcium and bone balance during space flight.

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“…When high sodium intake was combined with bed rest, another stimulus of increased bone resorption [ 86 , 185 ], excretion of bone resorption markers had almost doubled (about 35 % increase because of inactivity plus about 50 % increase because of high salt intake) at the end of the 2 weeks of bed rest, relative to baseline [ 186 ].…”

Section: Sodiummentioning

confidence: 99%

Nutrition and Bone Health in Space

Smith

Heer

Zwart

2014

Nutrition and Bone Health

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The effect of weightlessness on the human skeletal system is one of the greatest concerns in safely extending space missions [ 1 -11 ]. The ability to understand and counteract weightlessness-induced bone mineral loss will be vital to crew health and safety during and after extended-duration space station and exploration missions [ 1 -7 ]. Research on bone mineral loss during space fl ight has gone on for more than half a century, and recent studies have shown signifi cant progress in developing countermeasures that have proved to be effective, including good nutrition and exercise. We review the history of this research here and provide a summary of recent and ongoing studies, including efforts to counteract bone and calcium loss resulting from weightlessness. Key Points• The effect of weightlessness on the human skeletal system is one of the greatest concerns in safely extending space missions.• The ability to understand and counteract weightlessness-induced bone mineral loss will be vital to crew health and safety during and after extended-duration space station and exploration missions.• Research on bone mineral loss during space fl ight has gone on for more than half a century, and recent studies have shown signifi cant progress in developing countermeasures that have proved to be effective, including good nutrition and exercise.

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High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses

Abstract: Frings-Meuthen P, Buehlmeier J, Baecker N, Stehle P, Fimmers R, May F, Kluge G, Heer M. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses.

Cited by 37 publications

References 62 publications

The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?

The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?

Space Flight Calcium: Implications for Astronaut Health, Spacecraft Operations, and Earth

Nutrition and Bone Health in Space

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