High-speed spectral-domain optical coherence tomography at 13 μm wavelength

Abstract

Abstract:We demonstrate a high-speed spectral domain optical coherence tomography (SD-OCT) system capable of acquiring individual axial scans in 24.4 µs at a rate of 19,000 axial scans per second, using an InGaAs line scan camera and broadband light source centered at 1.31 µm. Sensitivity of >105 dB over a 2-mm depth range was obtained with a free-space axial resolution of 12-14 µm, in agreement with our signal-to-noise ratio predictions. Images of human tissue obtained in vivo with SD-OCT show similar penetration depths to those obtained with state-of-the-art time domain OCT despite the ten-fold higher image acquisition speed. These results demonstrate the potential of 1.3 µm SD-OCT for high-speed and high-sensitivity imaging in patients.

Fourier Domain Optical Coherence Tomography for Retinal Imaging with 800-nm Swept Source: Real-time Resampling in k-domain

“…The measured axial resolution increased beyond 2.0 mm. This degradation indicates that the interpolation process is sensitive to small errors at high fringe frequencies [8,28]. When a 1,000 A-lines/frame image was obtained, an acquisition speed of 2.0 frames per second (fps) was achieved.…”

“…In ophthalmology, OCT was already commercialized and widely used for non-invasive structural and quantitative imaging of the human retina and anterior segment [2][3][4][5]. Recently, Fourier-domain OCT (FD-OCT), which includes a spectral-domain method and a swept-source method, has become a preferred method owing to its superior features of higher acquisition speed and sensitivity [6][7][8][9][10]. Due to the limited number of camera pixels, spectral-domain OCT (FD/SD-OCT) has trade-offs among the axial resolution, imaging depth range, acquisition time, and sensitivity roll-off [11,12].…”

Molecular Contrast Optical Coherence Tomography: A Review

“…This A-scan is similar to that measured by time domain OCT, except that the SNR is improved by a factor equal to N/2 (56)(57)(58). Another form of FDOCT uses a monochromatic laser source that is swept in its wavelength during the signal acquisition process (21,56,59); the method leads to an equivalent SNR improvement. The improvement in the SNR for FDOCT is attributable to the much longer time window during which the signal associated with a single spatial pixel is acquired.…”

“…1). FDOCT (53) has also been termed spectral radar (54) and spectral-domain OCT (21,55). FDOCT differs from time domain OCT in that the detected light is spectrally resolved.…”

Wide wavelength tuning of sampled grating tunable twin-guide laser diodes

“…Besides this, they are also highly attractive light sources for gas sensing applications, 2 for fiber sensor interrogation 3 as well as for optical coherence tomography. 4 First widely tunable lasers have already been presented more than a decade ago. However, only a very limited amount of device types has been developed since then (an overview can be found in Refs.…”