High-strength double-network silk fibroin based hydrogel loaded with Icariin and BMSCs to inhibit osteoclasts and promote osteogenic differentiation to enhance bone repair

Liu, Huiling; Jiao, Yang; Forouzanfar, T.; Wu, Gang; Guo, Rui; Lin, Haiyan

doi:10.1016/j.bioadv.2024.213856

Biomaterials Advances

2024

DOI: 10.1016/j.bioadv.2024.213856

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High-strength double-network silk fibroin based hydrogel loaded with Icariin and BMSCs to inhibit osteoclasts and promote osteogenic differentiation to enhance bone repair

Huiling Liu,

Yang Jiao,

T. Forouzanfar

et al.

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Cited by 4 publications

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Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Shariati,

Bedar,

Huang

et al. 2024

Advanced Therapeutics

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Tissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. Osteoclast‐directed resorption and osteoblast‐directed formation of bone are essential to bone remodeling, and the crosstalk between these cells is vital to curating a sequence of events that culminate in the creation of bone tissue. Among bone biomaterial strategies, many have investigated the use of different material cues to direct the development and activity of osteoblasts. However, less attention has been given to exploring features that similarly target osteoclast formation and activity, with even fewer strategies demonstrating or integrating biomaterial‐directed modulation of osteoblast‐osteoclast coupling. This review aims to describe various biomaterial cues demonstrated to influence osteoclastogenesis and osteoclast function, emphasizing those that enhance a material construct's ability to achieve bone healing and regeneration. Additionally discussed are approaches that influence the communication between osteoclasts and osteoblasts, particularly in a manner that takes advantage of their coupling. Deepening the understanding of how biomaterial cues may dictate osteoclast differentiation, function, and influence on the microenvironment may enable the realization of bone‐replacement interventions with enhanced integrative and regenerative capacities.

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Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Shariati,

Bedar,

Huang

et al. 2024

Advanced Therapeutics

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An injectable, self-healing, and robust double-network composite hydrogel with incorporation of nano-lignin

Mei,

Zhu,

Bai

et al. 2025

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration

Wang,

Li,

et al. 2025

Materials Today Bio

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High-strength double-network silk fibroin based hydrogel loaded with Icariin and BMSCs to inhibit osteoclasts and promote osteogenic differentiation to enhance bone repair

Cited by 4 publications

References 39 publications

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

An injectable, self-healing, and robust double-network composite hydrogel with incorporation of nano-lignin

Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration

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