High strength zwitterionic nano-micelle hydrogels with superior self-healing, adhesive and ion conductive properties

Yu-rong, Sun; Lu, Shuaishuai; Liu, Qingshan; Ren, Yanwei; Ding, Yuanqing; Wu, Hailiang; He, Xiaohui; Shang, Yudong

doi:10.1016/j.eurpolymj.2020.109761

Cited by 45 publications

(21 citation statements)

References 31 publications

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“…In summary, wearable flexible sensors [ 83 , 84 , 85 ] for human health monitoring [ 86 , 87 , 88 , 89 , 90 ] have shown new advances. These flexible sensors can better monitor subtle changes in the external environment, such as temperature [ 91 , 92 , 93 ], humidity [ 91 , 94 ], and deformation [ 95 , 96 ], and are evolving rather fast.…”

Section: Numerical Resultsmentioning

confidence: 99%

“…In recent years, research into hydrogels has made significant breakthroughs (e.g., self-healing hydrogels [ 88 , 89 , 90 , 113 ], smart hydrogels [ 98 ], cellulose hydrogels [ 97 ], double chain hydrogels [ 114 ], supramolecular hydrogels [ 115 ], etc.). However, most of the research focuses on hydrogel functionality, as for flexible wearable sensors, drug delivery, and medical engineering.…”

Section: Concluding Remarksmentioning

confidence: 99%

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Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Zhang

Qiu

Elkhodary

et al. 2022

Gels

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Hydrogels are nowadays widely used in various biomedical applications, and show great potential for the making of devices such as biosensors, drug- delivery vectors, carriers, or matrices for cell cultures in tissue engineering, etc. In these applications, due to the irregular complex surface of the human body or its organs/structures, the devices are often designed with a small thickness, and are required to be flexible when attached to biological surfaces. The devices will deform as driven by human motion and under external loading. In terms of mechanical modeling, most of these devices can be abstracted as shells. In this paper, we propose a mixed graph-finite element method (FEM) phase field approach to model the fracture of curved shells composed of hydrogels, for biomedical applications. We present herein examples for the fracture of a wearable biosensor, a membrane-coated drug, and a matrix for a cell culture, each made of a hydrogel. Used in combination with experimental material testing, our method opens a new pathway to the efficient modeling of fracture in biomedical devices with surfaces of arbitrary curvature, helping in the design of devices with tunable fracture properties.

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Section: Numerical Resultsmentioning

confidence: 99%

Section: Concluding Remarksmentioning

confidence: 99%

Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Zhang

Qiu

Elkhodary

et al. 2022

Gels

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show abstract

“…On the premise of keeping enough antifouling properties, other functional groups which can be used to stabilize polymer networks are also gradually introduced to enhance zwitterionic hydrogels. There are two main categories: (1) introducing hydrophobic groups/intermolecular hydrogen-bond formation moieties into zwitterionic side-chain ( Figure 5 c) [ 54 , 55 , 56 , 57 ]; (2) copolymerization of zwitterionic monomers with different functional monomers ( Figure 5 d) [ 44 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ]. At present, through the selection of different monomers, zwitterionic hydrogels have been able to achieve various aspects of strength and elasticity regulation to promote their application.…”

Section: Zwitterionic Hydrogelsmentioning

confidence: 99%

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

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“… Overview of properties, materials, and applications of hydrogels. References: [i] = [ 123 , 124 , 125 ]; [ii] = [ 126 , 127 , 128 , 129 ]; [iii] = [ 130 ]; [iv] = [ 131 , 132 ]; [v] = [ 133 , 134 ]; [vi] = [ 135 , 136 ]; [vii] = [ 137 , 138 , 139 ]; [viii] = [ 140 , 141 ]; [ix] = [ 142 , 143 ]; [x] = [ 144 ]; [xi] = [ 145 ]; [xii] = [ 70 , 146 , 147 ]; [xiii] = [ 148 ]; [xiv] = [ 149 , 150 , 151 ]; [xv] = [ 152 , 153 ]; [xvi] = [ 154 , 155 ]; [xvii] = [ 156 , 157 , 158 , 159 ]; [xviii] = covered within this review …”

Section: Introductionmentioning

confidence: 99%

Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis

Meyer

Kara

2021

Engineering in Life Sciences

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High strength zwitterionic nano-micelle hydrogels with superior self-healing, adhesive and ion conductive properties

Cited by 45 publications

References 31 publications

Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis

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