High surface area polypyrrole scaffolds for tunable drug delivery

Sharma, Manisha; Waterhouse, Geoffrey I. N.; Loader, Samuel W.C.; Garg, Sanjay; Svirskis, Darren

doi:10.1016/j.ijpharm.2013.01.006

Cited by 104 publications

(87 citation statements)

References 25 publications

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“…These studies are particularly useful for membrane and sensing applications, and are related to the diffusion through the pores that is necessary for catalytic and electrode applications. CBPM have also been used in other transport applications such as for cell culture, 210,211 for drug delivery, 212,213 and as membranes and filters, 214 applications we do not cover in this review. 86 Reproduced with permission from the American Chemical Society.…”

Section: Wetting Applicationsmentioning

confidence: 99%

A colloidoscope of colloid-based porous materials and their uses

et al. 2016

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Nature evolved a variety of hierarchical structures that produce sophisticated functions. Inspired by these natural materials, colloidal self-assembly provides a convenient way to produce structures from simple building blocks with a variety of complex functions beyond those found in nature. In particular, colloid-based porous materials (CBPM) can be made from a wide variety of materials. The internal structure of CBPM also has several key attributes, namely porosity on a sub-micrometer length scale, interconnectivity of these pores, and a controllable degree of order. The combination of structure and composition allow CBPM to attain properties important for modern applications such as photonic inks, colorimetric sensors, self-cleaning surfaces, water purification systems, or batteries. This review summarizes recent developments in the field of CBPM, including principles for their design, fabrication, and applications, with a particular focus on structural features and materials' properties that enable these applications. We begin with a short introduction to the wide variety of patterns that can be generated by colloidal self-assembly and templating processes. We then discuss different applications of such structures, focusing on optics, wetting, sensing, catalysis, and electrodes. Different fields of applications require different properties, yet the modularity of the assembly process of CBPM provides a high degree of tunability and tailorability in composition and structure. We examine the significance of properties such as structure, composition, and degree of order on the materials' functions and use, as well as trends in and future directions for the development of CBPM.

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Section: Wetting Applicationsmentioning

confidence: 99%

A colloidoscope of colloid-based porous materials and their uses

et al. 2016

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“…They and (white down-pointing white triangle) thick (700 μC cm −2 ) films stimulated by CV at a sweep rate 100 mV s −1 [108]. (Black circle) Risperidone release from nanostructured PPy stimulated at ±0.6 V Ag/ AgCl; 0.5 Hz and (black down-pointing black triangle) without electrical stimulation, (white square) release from conventional PPy films stimulated at ±0.6 V vs. Ag/AgCl; 0.5 Hz and (black triangle) without electrical stimulation [115]. Aspirin release: (black square) from conventional non-stimulated PPy, (white diamond) unstimulated nanostructured PPy, (black diamond) conventional stimulated PPy (black hexagon) stimulated nanostructure at −0.6 V vs. SCE [139] reported that RVC electrode is a better system for this drug as incorporated and released larger amounts of TCF than the ITO electrodes due to its larger surface area even if more monomer pyrrole units were needed.…”

Section: Membrane Porosity and Thicknessmentioning

confidence: 99%

“…Sharma et al [115] reported the electropolymerisation of PPy on a 3-dimensionally macroporous poly-methyl methacrylate (PMMA) colloidal crystal template of ≈430 nm diameter supported on stainless steel. A cationic drug, risperidone, was physically entrapped inside the macroporous PPy film (6-7 μm thick) by dropping 20 μL of methanol containing 0.1 M risperidone.…”

Section: Closed Packed Colloid Crystal Array Templatesmentioning

confidence: 99%

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

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Over the last 40 years, electrically conductive polymers have become well established as important electrode materials. Polyanilines, polythiophenes and polypyrroles have received particular attention due to their ease of synthesis, chemical stability, mechanical robustness and the ability to tailor their properties. Electrochemical synthesis of these materials as films have proved to be a robust and simple way to realise surface layers with controlled thickness, electrical conductivity and ion transport. In the last decade, the biomedical compatibility of electrodeposited polymers has become recognised; in particular, polypyrroles have been studied extensively and can provide an effective route to pharmaceutical drug release. The factors controlling the electrodeposition of this polymer from practical electrolytes are considered in this review including electrolyte composition and operating conditions such as the temperature and electrode potential. Voltammetry and current-time behaviour are seen to be effective techniques for film characterisation during and after their formation. The degree of take-up and the rate of drug release depend greatly on the structure, composition and oxidation state of the polymer film. Specialised aspects are considered, including galvanic cells with a Mg anode, use of catalytic nanomotors or implantable biofuel cells for a self-powered drug delivery system and nanoporous surfaces and nanostructures. Following a survey of polymer and drug types, progress in this field is summarised and aspects requiring further research are highlighted.

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“…By combining templates, including solid and molecular templates, many interesting results have been reported. Sharma and co-workers [73] employed monodispersed poly(methyl methacrylate) (PMMA) colloids ~430 nm in diameter as three-dimensional (3D) colloidal crystal templates and SDBS as a surfactant for fabricating 3D macroporous PPy inverse opals. There are three main advantages to this method: (i) although PMMA colloids are solid templates and require chemical treatment to remove them, they can be easily dissolved by common solvents, (ii) the inverse opal PPy presented a higher surface area (19.2 m 2 ·g −1 ) as compared to conventional non-porous PPy films (4.8 m 2 ·g −1 ); and (iii) SDBS not only acts as a surfactant but also a dopant for PPy to trap cations present in the surrounding solution.…”

Section: Recent Advances In the Synthesis Of Cp Nanomaterialsmentioning

confidence: 99%

“…Recently, there has been substantial effort to fabricate drug delivery systems based on smart materials [73]. CPs that possess ion-exchange properties are being studied as promising materials for drug reservoirs for this purpose.…”

Section: Drug Carriersmentioning

confidence: 99%

Recent Advances in Nanostructured Conducting Polymers: from Synthesis to Practical Applications

2016

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Abstract:Conducting polymers (CPs) have been widely studied to realize advanced technologies in various areas such as chemical and biosensors, catalysts, photovoltaic cells, batteries, supercapacitors, and others. In particular, hybridization of CPs with inorganic species has allowed the production of promising functional materials with improved performance in various applications. Consequently, many important studies on CPs have been carried out over the last decade, and numerous researchers remain attracted to CPs from a technological perspective. In this review, we provide a theoretical classification of fabrication techniques and a brief summary of the most recent developments in synthesis methods. We evaluate the efficacy and benefits of these methods for the preparation of pure CP nanomaterials and nanohybrids, presenting the newest trends from around the world with 205 references, most of which are from the last three years. Furthermore, we also evaluate the effects of various factors on the structures and properties of CP nanomaterials, citing a large variety of publications.

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High surface area polypyrrole scaffolds for tunable drug delivery

Cited by 104 publications

References 25 publications

A colloidoscope of colloid-based porous materials and their uses

A colloidoscope of colloid-based porous materials and their uses

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Recent Advances in Nanostructured Conducting Polymers: from Synthesis to Practical Applications

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