High Systemic Immune Inflammation Index Is Associated With Low Skeletal Muscle Quantity in Resectable Pancreatic Ductal Adenocarcinoma

Aziz, Moutaz; Dongen, Jelle C van; Saida, Lawlaw; Suker, Mustafa; Vugt, Jeroen L.A. van; Putten, Yordi van; Sideras, Kostandinos; Groen, Jesse V.; Mieog, J. Sven D.; Lucassen, C.J.; Droop, Anneke; Mauff, Katya; Feshtali, Shirin; Koerkamp, Bas Groot; Mustafa, Dana A. M.; Eijck, Casper J. van

doi:10.3389/fonc.2022.827755

Cited by 9 publications

(10 citation statements)

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“…( 11 ) in 2014, which could reflect the local immune response and systemic inflammation in the whole human body ( 12 – 15 ). SII has been used in past studies to predict and evaluate the prognosis of various solid tumors, such as gastric cancer ( 16 , 17 ), non-small cell lung cancer ( 18 , 19 ), pancreatic cancer ( 20 ), and esophageal cancer ( 21 , 22 ). In addition, SII also has a high value for the prognosis of cardiovascular disease ( 23 – 27 ).…”

Section: Introductionmentioning

confidence: 99%

Association between SII and hepatic steatosis and liver fibrosis: A population-based study

et al. 2022

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BackgroundThe systemic immune-inflammation index (SII) is a novel marker of inflammation, and hepatic steatosis and fibrosis are associated with inflammation. This study aimed to investigate the possible relationship between SII and hepatic steatosis and fibrosis.MethodsThe datasets from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were used in a cross-sectional investigation. Multivariate linear regression models were used to examine the linear connection between SII and controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Fitted smoothing curves and threshold effect analysis were used to describe the nonlinear relationship.ResultsThis population-based study included a total of 6,792 adults aged 18–80 years. In a multivariate linear regression analysis, a significant positive association between SII and CAP was shown [0.006 (0.001, 0.010)]. This positive association in a subgroup analysis was maintained in men [0.011 (0.004, 0.018)] but not in women. Furthermore, the association between SII and CAP was nonlinear; using a two-segment linear regression model, we found an inverted U-shaped relationship between SII and CAP with an inflection point of 687.059 (1,000 cells/µl). The results of the multiple regression analysis showed that the relationship between SII and LSM was not significant (P = 0.263).ConclusionsOur findings imply that increased SII levels are linked to hepatic steatosis, but SII is not linked to liver fibrosis. To confirm our findings, more large-scale prospective investigations are needed.

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Section: Introductionmentioning

confidence: 99%

Association between SII and hepatic steatosis and liver fibrosis: A population-based study

et al. 2022

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“…Only 5 studies explored the relationship between pretreatment SMI and PFS. [ 28 , 31 , 35 , 38 , 44 ] The pooled demonstrated that lower pretreatment SMI was a risk factor of worse PFS in pancreatic carcinoma patients (HR = 1.41, 95% CI: 1.08–1.84, P = .012; I 2 = 67.1%, P = .016) (Fig. 3 ; Table 2 ).…”

Section: Resultsmentioning

confidence: 97%

“…[ 49 ] A lot of studies have indicated that skeletal muscle plays an important role in the systematic inflammation. [ 44 , 50 ] Besides, several inflammatory parameters such as the neutrophil to lymphocyte ratio, white blood cell count, C-reactive protein levels, erythrocyte sedimentation rate and systemic immune-inflammation index were found to be higher in sarcopenic patients. [ 44 , 51 ] As mentioned above, most of these inflammatory indexes have a high prognostic value in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…[ 44 , 50 ] Besides, several inflammatory parameters such as the neutrophil to lymphocyte ratio, white blood cell count, C-reactive protein levels, erythrocyte sedimentation rate and systemic immune-inflammation index were found to be higher in sarcopenic patients. [ 44 , 51 ] As mentioned above, most of these inflammatory indexes have a high prognostic value in cancer patients. Thus, overall, it is believed that SMI could show a high prognostic value in pancreatic carcinoma and our results have well certified this conjecture.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of pretreatment skeletal muscle index in pancreatic carcinoma patients: A meta-analysis

Liao

Xie

et al. 2023

Medicine

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Background: The association between pretreatment skeletal muscle index (SMI) and long-term survival of pancreatic carcinoma patients remains unclear up to now. Methods: The PubMed, Web of Science and EMBASE databases were searched up to March 1, 2022 for relevant studies. The primary and secondary outcomes were overall survival and progression-free survival, respectively. The hazard ratios (HRs) and 95% confidence intervals (CIs) were combined to assess the relationship between pretreatment SMI and prognosis of pancreatic carcinoma patients. All statistical analysis was conducted by STATA 15.0 software. Results: Twenty retrospective studies involving 3765 patients were included. The pooled results demonstrated that lower pretreatment SMI was significantly related to poorer overall survival (HR = 1.42, 95% CI: 1.25–1.62, P < .001) and progression-free survival (HR = 1.41, 95% CI: 1.08–1.84, P = .012). Besides subgroup analysis based on the treatment (non-surgery vs surgery) and tumor stage (advanced vs early stage) showed similar results. Conclusion: Pretreatment SMI could serve as a promising and reliable prognostic factor for pancreatic carcinoma patients and lower pretreatment SMI predicted worse prognosis.

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“…Computed tomography (CT) measured body composition, including subcutaneous and visceral fat and muscle, has been shown to be associated with systemic inflammatory immune and metabolic status. More importantly, it has been recognized as a predictor of many tumor and metabolic diseases [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

CT-measured body composition radiomics predict lymph node metastasis in localized pancreatic ductal adenocarcinoma

et al. 2023

Discov Onc

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Background To explored the value of CT-measured body composition radiomics in preoperative evaluation of lymph node metastasis (LNM) in localized pancreatic ductal adenocarcinoma (LPDAC). Methods We retrospectively collected patients with LPDAC who underwent surgical resection from January 2016 to June 2022. According to whether there was LNM after operation, the patients were divided into LNM group and non-LNM group in both male and female patients. The patient’s body composition was measured by CT images at the level of the L3 vertebral body before surgery, and the radiomics features of adipose tissue and muscle were extracted. Multivariate logistic regression (forward LR) analyses were used to determine the predictors of LNM from male and female patient, respectively. Sexual dimorphism prediction signature using adipose tissue radiomics features, muscle tissue radiomics features and combined signature of both were developed and compared. The model performance is evaluated on discrimination and validated through a leave-one-out cross-validation method. Results A total of 196 patients (mean age, 60 years ± 9 [SD]; 117 men) were enrolled, including 59 LNM in male and 36 LNM in female. Both male and female CT-measured body composition radiomics signatures have a certain predictive power on LNM of LPDAC. Among them, the female adipose tissue signature showed the highest performance (area under the ROC curve (AUC), 0.895), and leave one out cross validation (LOOCV) indicated that the signature could accurately classify 83.5% of cases; The prediction efficiency of the signature can be further improved after adding the muscle radiomics features (AUC, 0.924, and the accuracy of the LOOCV was 87.3%); The abilities of male adipose tissue and muscle tissue radiomics signatures in predicting LNM of LPDAC was similar, AUC was 0.735 and 0.773, respectively, and the accuracy of LOOCV was 62.4% and 68.4%, respectively. Conclusions CT-measured body composition Radiomics strategy showed good performance for predicting LNM in LPDAC, and has sexual dimorphism. It may provide a reference for individual treatment of LPDAC and related research about body composition in the future.

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High Systemic Immune Inflammation Index Is Associated With Low Skeletal Muscle Quantity in Resectable Pancreatic Ductal Adenocarcinoma

Cited by 9 publications

References 53 publications

Association between SII and hepatic steatosis and liver fibrosis: A population-based study

Association between SII and hepatic steatosis and liver fibrosis: A population-based study

Prognostic value of pretreatment skeletal muscle index in pancreatic carcinoma patients: A meta-analysis

CT-measured body composition radiomics predict lymph node metastasis in localized pancreatic ductal adenocarcinoma

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