High T2-weighted signal intensity is associated with myocardial deformation in hypertrophic cardiomyopathy

Shi, Rong; An, Dong‐Aolei; Chen, Binghua; Wu, Rui; Wu, Chong-Wen; Du, Liang; Zhu, Jiong; Jiang, Meng; Xu, Jianrong; Wu, Lian‐Ming

doi:10.1038/s41598-019-39456-z

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…A previous study (27) found global strain to be related to LV mass and LGE. Other studies (17,18) on regional strain of HCM patients reported regional strain to be correlated with LVWT, LGE, and LVEF.…”

Section: Discussionmentioning

confidence: 87%

Prognostic value of regional strain by cardiovascular magnetic resonance feature tracking in hypertrophic cardiomyopathy

Chen¹,

Pan²,

Shu³

et al. 2022

Quant Imaging Med Surg

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Background: Few studies have demonstrated the performance of regional strain by cardiovascular magnetic resonance (CMR) feature tracking in hypertrophic cardiomyopathy (HCM) patients, and the prognostic value of segmental strain remains unknown. This study aimed to explore the prognostic implications of strain parameters generated by CMR feature tracking analysis in HCM patients.Methods: In total, 104 clinically diagnosed HCM patients and 30 healthy volunteers were enrolled in this study, and all patients underwent a standard CMR examination. Global and regional strain was computed by short axis, 2-, 3-, and 4-chamber view cine MR imaging using specialized software. Cardiac structure, function, and myocardial strain were compared between the control group and HCM patients, and the event and event-free groups. Univariate and multivariate Cox regression analyses were performed to evaluate the correlations between clinical and CMR parameters and poor prognosis.Results: During the follow-up time, 8 patients reached the primary end points and 14 patients reached secondary end points. Regional radial strain of hypertrophic segments (RRS) and regional circumferential strain of hypertrophic segments (RCS) were worse in HCM patients with primary and secondary end points.In univariate Cox regression analysis of RRS, RCS were associated with primary and secondary end points.

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Section: Discussionmentioning

confidence: 87%

Prognostic value of regional strain by cardiovascular magnetic resonance feature tracking in hypertrophic cardiomyopathy

Chen¹,

Pan²,

Shu³

et al. 2022

Quant Imaging Med Surg

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“…Most of the literature data on HCM have focused on LV changes, while few studies have characterized RV abnormalities using CMR [21][22][23][24]. The main nding of our study is that RV anomalies assessed with CMR in HCM patients, such as increased wall thickness, dilatation and systolic dysfunction have a signi cant role in predicting prognosis in addition to those of the LV.…”

Section: Discussionmentioning

confidence: 64%

The prognostic role of right ventricular dysfunction in patients with hypertrophic cardiomyopathy

Mushtaq

Monti

Rossi

et al. 2023

Int J Cardiovasc Imaging

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Background. Hypertrophic cardiomyopathy (HCM) primarily affects the left ventricle (LV) sparing the right ventricle (RV) in vast majority of cases. However, several studies employing CMR have revealed that myocardial hypertrophy may also involve the RV.Aim of the study. To assess RV size and function in a large prospectively cohort of HCM patients and to evaluate whether these parameters in association with other MR ndings can predict cardiac events Methods. Two participating centers prospectively included patients with known or suspected HCM between 2011 and 2017. CMR studies were performed with three different scanners. Outcome measures were a composite of ventricular arrhythmias, hospitalization for HF and cardiac death.Results. Of 607 consecutive patients with known or suspected HCM, 315 had complete follow-up information (mean 65 ± 20 months). Among them, 115 patients developed major cardiac events (MACE) during follow-up. At CMR evaluation, patients with events had higher left atrium (LA) diameter (41.5 ± 8 mm vs. 37.17 ± 7.6 mm, p < 0.0001), LV mass (156.7 vs. 144 g, p = 0.005) and myocardial LGE (4.3% vs.1.9%, p = 0.001). Similarly, patients with events had lower RV stroke volume index (42.7 vs. 47.0, p = 0.0003) and higher prevalence of both RV hypertrophy (16.4% vs. 4.7%, p = 0.0005) and reduced RV ejection fraction (12.2% vs. 4.4%, p = 0.006). In the multivariate analysis, LA diameter and RV stroke volume index were the strongest predictors of events (p < 0.001 and p = 0.0006, respectively) Conclusions Anatomic and functional RV anomalies detected and characterized with CMR may have may have a major role in predicting the prognosis of HCM patients.

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“…The usefulness of MRI tissue tracking in the assessment of ventricular function in HCM patients warrants further investigation. Additionally, the contribution of high T2-weighted signal intensity to RV myocardial deformation in HCM patients needs to be investigated 19 . Finally, it should be elucidated whether a novel parameter, namely, the ventricular global function index as determined by MRI, could be useful in detecting subclinical RV function impairment 20 .…”

Section: Discussionmentioning

confidence: 99%

Predictors of right ventricular function and size in patients with hypertrophic cardiomyopathy

Śpiewak

Kłopotowski

Mazurkiewicz

et al. 2020

Sci Rep

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We investigated factors associated with right ventricular (RV) function and size in hypertrophic cardiomyopathy (HCM) patients. Two hundred fifty-three consecutive HCM patients and 20 healthy volunteers underwent cardiac magnetic resonance examination. In addition to measuring RV function (ejection fraction—RVEF) and size (end-diastolic volume—RVEDV), each image was inspected for the presence of RV and left ventricular (LV) hypertrophy, and the maximal wall thickness of the left and right ventricles was recorded. HCM patients had higher RVEF and lower RVEDV than healthy volunteers and similar RV mass. The mean RV wall thickness was higher in HCM patients than in controls. LV late gadolinium enhancement (LGE) was present in 89.7% of patients, and RV LGE was present in 3.1% of patients (p < 0.0001). Univariate and multivariable analyses revealed that LVEF, peak LV outflow tract gradient, LV LGE, maximal LV wall thickness, and tricuspid regurgitation (TR) volume by magnetic resonance imaging were positive predictors of RVEF. In addition to TR volume, the only independent predictor of RVEF < 45% was LVEF (odds ratio = 0.80, 95% confidence interval 0.67–0.95). Multivariable analysis revealed that LVEDV and TR volume were positive predictors of RVEDV, whereas negative predictors were RVEF, maximal RV wall thickness, LV LGE, and age. Neither estimated systolic pulmonary artery pressure nor TR grade by echocardiography proved to be predictors of RVEF. There were no differences in either the maximal RV wall thickness or the maximal left ventricular (LV) wall thickness in patients stratified according to NYHA functional class (p = 0.93 and p = 0.15, respectively). There were no differences in mean RV wall thickness in patients categorised based on the number of clinical risk factors for sudden cardiac death (SCD), i.e., non-sustained ventricular tachycardia, family history of SCD, or unexplained syncope (p = 0.79). On the other hand, there was a weak positive association between RV hypertrophy and the estimated probability of SCD at 5 years (rho = 0.16, p = 0.01). RV systolic dysfunction measured as decreased RVEF was uncommon in HCM and was associated with poor LV systolic function. LV also had a significant impact on RV size.

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High T2-weighted signal intensity is associated with myocardial deformation in hypertrophic cardiomyopathy

Cited by 6 publications

References 33 publications

Prognostic value of regional strain by cardiovascular magnetic resonance feature tracking in hypertrophic cardiomyopathy

Prognostic value of regional strain by cardiovascular magnetic resonance feature tracking in hypertrophic cardiomyopathy

The prognostic role of right ventricular dysfunction in patients with hypertrophic cardiomyopathy

Predictors of right ventricular function and size in patients with hypertrophic cardiomyopathy

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