2023
DOI: 10.1002/adhm.202300376
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High Targeting Specificity toward Pulmonary Inflammation Using Mesenchymal Stem Cell‐Hybrid Nanovehicle for an Efficient Inflammation Intervention

Abstract: Pulmonary inflammation is one of the most reported tissue inflammations in clinic. Successful suppression of inflammation is vital to prevent further inevitably fatal lung degeneration. Glucocorticoid hormone, such as methylprednisolone (MP), is the most applied strategy to control the inflammatory progression yet faces the challenge of systemic side effects caused by the requirement of large‐dosage and frequent administration. Highly efficient delivery of MP specifically targeted to inflammatory lung sites ma… Show more

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Cited by 8 publications
(3 citation statements)
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“…Inflammation has been shown to be closely associated with the stage of development of action and malignant progression of most types of tumors, as well as with the efficacy of anticancer therapies [83,84]. Specifically, long-term chronic inflammation is associated with immunosuppression and would provide a favorable microenvironment for tumorigenesis, progression and metastasis [85,86].…”
Section: Anti-inflammatory and Immunomodulatorymentioning
confidence: 99%
“…Inflammation has been shown to be closely associated with the stage of development of action and malignant progression of most types of tumors, as well as with the efficacy of anticancer therapies [83,84]. Specifically, long-term chronic inflammation is associated with immunosuppression and would provide a favorable microenvironment for tumorigenesis, progression and metastasis [85,86].…”
Section: Anti-inflammatory and Immunomodulatorymentioning
confidence: 99%
“…Inflammation is the first response that occurs after an injury or infection and is an immune defense process of the body (9). If the inflammatory process continues for too long, an excessive number of activated cells are drawn to the site of the damage and release an excessive amount of enzymes, chemokines, etc., which is harmful to tissue repair and promotes further deterioration (7).…”
Section: Introductionmentioning
confidence: 99%
“…Glucocorticoids have a rapid, powerful, non-specific anti-inflammatory effect and are effective in a wide range of inflammatory conditions. However, all kinds of drugs have their limitations, and the side effects of drugs may make the benefits outweigh the disadvantages (9,15). For example, longterm use of glucocorticoids can reduce the body's resistance to pathogenic microorganisms, induce or aggravate infections, induce ulcers, aggravate mental illness, and cause osteoporosis, muscle atrophy, and delayed wound healing (15,16).…”
Section: Introductionmentioning
confidence: 99%