High-throughput and trace analysis of diazepam in plasma using DART-MS/MS and its pharmacokinetic application

Liu, Yingze; Su, Chong; Zhang, Yuyao; Zhang, Di; Li, Yaoshuang; Gu, Jingkai; En-si, Wang; Sun, Dawei

doi:10.1016/j.ab.2021.114435

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…Chromatography‐free MS techniques under ambient and open‐air conditions have acquired an essential role in this field due to their inherent speed, simplicity, versatility, and selectivity (Morato & Cooks, 2021). To date, many ionization techniques such as desorption electrospray ionization (DESI) (Beng et al, 2021; Chen et al, 2005; Kauppila et al, 2006), direct analysis in real‐time (DART) (Khaled et al, 2020; Liu et al, 2021; Sisco et al, 2022), desorption atmospheric pressure chemical ionization (DAPCI) (Pitman & LaCourse, 2020; Zhang et al, 2010), electrospray‐assisted laser desorption/ionization (ELDI) (Morato & Cooks, 2021), atmospheric solids analysis probe (ASAP) (Carrizo et al, 2016), and matrix‐assisted laser desorption electrospray ionization (MALDESI) (Barry et al, 2015) have been developed to rapidly analyze a variety of pharmaceutical compounds by MS. Some of the pharmaceutical applications in the field of ambient ionization MS techniques have already been summarized in detail in several published review articles (Chernetsova & Morlock, 2011; Culzoni et al, 2014; Smoluch et al, 2016; Yang & Deng, 2016).…”

Section: Ms‐based Methods In the Analysis Of Small‐molecule Chemical ...mentioning

confidence: 99%

What is the role of current mass spectrometry in pharmaceutical analysis?

Khalikova

Jireš

Horáček

et al. 2023

Mass Spectrometry Reviews

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The role of mass spectrometry (MS) has become more important in most application domains in recent years. Pharmaceutical analysis is specific due to its stringent regulation procedures, the need for good laboratory/manufacturing practices, and a large number of routine quality control analyses to be carried out. The role of MS is, therefore, very different throughout the whole drug development cycle. While it dominates within the drug discovery and development phase, in routine quality control, the role of MS is minor and indispensable only for selected applications. Moreover, its role is very different in the case of analysis of small molecule pharmaceuticals and biopharmaceuticals. Our review explains the role of current MS in the analysis of both small‐molecule chemical drugs and biopharmaceuticals. Important features of MS‐based technologies being implemented, method requirements, and related challenges are discussed. The differences in analytical procedures for small molecule pharmaceuticals and biopharmaceuticals are pointed out. While a single method or a small set of methods is usually sufficient for quality control in the case of small molecule pharmaceuticals and MS is often not indispensable, a large panel of methods including extensive use of MS must be used for quality control of biopharmaceuticals. Finally, expected development and future trends are outlined.

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Section: Ms‐based Methods In the Analysis Of Small‐molecule Chemical ...mentioning

confidence: 99%

What is the role of current mass spectrometry in pharmaceutical analysis?

Khalikova

Jireš

Horáček

et al. 2023

Mass Spectrometry Reviews

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“…The method was evaluated with conducted a systematic study of paper substrate-solvent combinations in the analysis of illicit drugs and chemical warfare agents to determine optimal conditions for different compound types. 59 Aside from paper spray, DART-MS has also been readily utilized in the rapid analysis of drugs, including for the detection of synthetic cathinones in blood and urine, 60 the analysis of benzodiazepines in plasma, 61 the detection of cannabinoids in various complex matrices 62 and for the analysis of illicit drugs in electronic cigarette aerosols. 63 Recently, the applications of ambient ionization to drugs analysis have extended beyond the laboratory, with research focusing on the development of hand-held tools and methods that could be used in the field for the analysis of real-world samples to truly test the feasibility of such techniques.…”

Section: Forensics and Securitymentioning

confidence: 99%

“…conducted a systematic study of paper substrate‐solvent combinations in the analysis of illicit drugs and chemical warfare agents to determine optimal conditions for different compound types. 59 Aside from paper spray, DART‐MS has also been readily utilized in the rapid analysis of drugs, including for the detection of synthetic cathinones in blood and urine, 60 the analysis of benzodiazepines in plasma, 61 the detection of cannabinoids in various complex matrices 62 and for the analysis of illicit drugs in electronic cigarette aerosols. 63 …”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

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Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

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“…Additionally, DART is more efficient when increased plasma temperatures are used for the analysis of thermally stable, both polar and non-polar, volatile analytes with a molecular weight of no more than 1000 Da (156). DART has many applications, including food (163), forensics (161,162), environmental (166), and drug (167,168) analysis.…”

Section: Direct Analysis In Real Time (Dart)mentioning

confidence: 99%

Integrated biorecognition : mass spectrometry approaches

Geballa-Koukoula

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12 stakeholders to act on improving natural resources and ensure enduring socioeconomic growth and planet protection (9).Another trend that might shape the future structure of monitoring systems is citizen science, i.e., collaboration and participation of citizens in scientific practices and research, for instance with the development of consumer-operable testing devices (10). Decentralized consumer-based testing provides individuals with the possibility of personalized point-of-care (POC) testing and screening diagnostics in many fields (11), including, but not limited to, food safety (12) and clinical applications (13, 14). On top of that, use of a ubiquitous readout system, such as smartphones, potentially in combination with wearable sensors, induces semi-quantitative possibilities and increases confidence in interpreting the result (15). Apart from the described citizen science approach during product deployment, crowdsourcing in science during the research and development (R&D) stage can improve practices and results, influencing directly the targeted population ( 10).An additional challenge for the future monitoring systems is climate changeinduced changes. Results of climate change vary from extreme drought to rise of sea levels, which amend the quality of life of individuals worldwide (16). Especially in terms of monitoring systems, the food safety sector, involving farming, crop production, and the nutritional content of crops, has already been impacted by long-term variations in temperature, humidity, and the frequency of extreme weather phenomena (17). Climate change may alter crops' susceptibility to germs, toxin-producing bacteria and mycotoxin-producing fungi, risking consumers' health. Even marine species are in danger because of the proliferation of toxin-producing algae because of increased temperatures (18). The results of climate change on crop production are already evident in literature where a 25% of global agricultural crop contamination with mycotoxin is estimated to be above the legal limits (19), underlining the need for fast, unambiguous identification and quantification of food contaminants.It is safe to assume that current monitoring protocols will be insufficient in the future because of the increased demand for official control from monitoring laboratories that will be caused due to the aforementioned changes. Already, despite its elaborate monitoring procedures, the food-safety system has been stressed, with incidences of food safety-related scandals and contaminated commodities reaching the market (20, 21). Combining screening and confirmation methods, two seemingly incompatible orthogonal techniques, provides improved and accurate methods with high throughput, sensitivity, robustness, and ease of use, which are necessary for future monitoring systems. To offer an elaborate background and understanding, the following parts of the introduction describe the classic analytical chemistry techniques that are coupled in order to develop the novel approaches discussed in the research c...

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High-throughput and trace analysis of diazepam in plasma using DART-MS/MS and its pharmacokinetic application

Cited by 10 publications

References 43 publications

What is the role of current mass spectrometry in pharmaceutical analysis?

What is the role of current mass spectrometry in pharmaceutical analysis?

Applications of ambient ionization mass spectrometry in 2021: An annual review

Integrated biorecognition : mass spectrometry approaches

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