High throughput chiral analysis of urinary amphetamines by GC-MS using a short narrow-bore capillary column

Reproducible chiral capillary electrophoresis of methamphetamine and its related compounds using a chemically modified capillary having diol groups

“…Although analyses of MA and its related compounds commonly use GC-MS and LC-MS(-MS) [1][2][3], CE has many advantages especially when chiral analysis is required; CE is fast and cost effective, and gives highresolution separation of target compounds, and chiral separation can be easily accomplished by adding a chiral selector to the BGE [22]. For chiral analysis of MA and its related compounds in human specimens, CE should gain more popularity.…”

“…Many methods for analysis of amphetamines and their metabolites in human specimens by gas chromatography (GC)-mass spectrometry (MS), liquid chromatography (LC)-MS(-MS), and capillary electrophoresis (CE) with and without MS have been reported [1][2][3][4][5][6][7][8][9][10][11]. The importance of chiral analysis has increased in recent years.…”

“…In criminal investigations, it is necessary to discriminate illegal abuse from legitimate clinical use of amphetamines, because selegiline (L-deprenyl) used for treatment of Parkinson's disease produces L-methamphetamine (L-MA) and its metabolite L-amphetamine (L-AP); famprofazone used for pain control also produces both D-MA and L-MA and their metabolites in human bodies. Among various methods mentioned above [1][2][3][4][5][6][7][8][9][10][11], we have mainly reported the chiral analysis of MA and related compounds by CE-diode array detection [4,7,8] and CE-MS [5,9,10]. CE is a powerful tool especially for chiral analysis of amphetamines; the selectivity can be easily tuned by adjusting types and concentrations of chiral selectors, such as cyclodextrins (CDs) and their derivatives [4][5][6].…”

Accumulation of intravenously administered methamphetamine in stomach contents

“…When the route of MAMP administration is disputed, the stomachto-blood MAMP ratio and the existence of fresh injection marks are useful for judging the route. In addition, substantial amounts of amphetamine (AMP), an active metabolite of MAMP, appear in the blood of deceased who survive for several hours or more after use of MAMP [12,13]; when rapid death occurs, it is diffi cult to detect AMP in blood and organ tissues [14,15]. Quantitative analysis of AMP in the stomach contents may, therefore, give additional information on the route of MAMP administration.…”

Seized methamphetamine samples with unique profiles of stable nitrogen isotopic composition documented by stable isotope ratio mass spectrometry

“…The abuse of methamphetamine (MA), an amphetaminetype stimulant (ATS), is one of the most serious social problems in Japan [1,2]. Hundreds of kilograms of MA-HCl have been seized over the years, and most of them were smuggled in from other countries.…”