High Throughput Screening in Drug Discovery: Problems
And Solutions
Dmitry M. Hushpulian,
Irina N. Gaisina,
Sergey V. Nikulin
et al.
Abstract:World-wide introduction of high throughput screening (HTS) methods in
drug discovery research did not result in the increased number of novel medications on
the market. We discuss novel trends in drug discovery that came from the understanding
that majority of diseases are multifactorial and that one enzyme has many protein
substrates. Hence, new approaches are focused on development of drugs, which (1)
trigger survival pathways to return the organism to homeostatic balance, and (2)
inhibit enzymes modifying h… Show more
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