High urinary bisphenol A concentrations in workers and possible laboratory abnormalities

Wang, Rui; Hua, Jingyi; Chen, Minjian; Xia, Yankai; Qi, Zhang; Zhao, Renzheng; Zhou, Wei; Zhang, Zhengdong; Wang, Bingling

doi:10.1136/oemed-2011-100529

Cited by 80 publications

(43 citation statements)

References 26 publications

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“…Indeed recent studies have shown that workers in epoxy resin factories can have approximately 1000 times higher urinary BPA concentrations compared with control groups (He et al, 2009;Melzer et al, 2010;Wang et al, 2012). The highest levels measured were almost up to 10 mM (Wang et al, 2012), which is within the effective concentration range of Ca 21 channels block by BPA. High exposure to BPA has also been reported for patients, particularly premature infants undergoing intensive medical care treatment (Calafat et al, 2009).…”

Section: Discussionmentioning

confidence: 91%

Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements

et al. 2012

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Section: Discussionmentioning

confidence: 91%

Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements

et al. 2012

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“…BPA was first synthesized in 1891, and as early as in 1936 it was demonstrated that it imitates the activity of the hormone estradiol (Dodds and Lawson 1936). Despite a very strong estrogen activity, BPA has been commercially used since 1957, and despite the fact that its endocrine-disrupting activity was discovered (Krishnan et al 1993), BPA has become a high production volume chemical (Wang et al 2012). Worldwide annual production, which in the case of BPA reached 4.6 million t in 2012, is constantly increasing.…”

Section: Bisphenol Amentioning

confidence: 99%

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2016

Czech J. Anim. Sci.

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A range of substances that are released into the environment, foodstuffs and drinking water as a result of human activity were originally considered relatively harmless, and it was only later that their adverse effects were discovered. In general the use of such substances is currently restricted, and they are often replaced by other substances. This applies also in the case of a range of endocrine disruptors. These substances have the capacity to disturb the balance of physiological functions of the organism on the level of hormonal regulation, and their pleiotropic spectrum of effects is very difficult to predict. Endocrine disruptors include the currently intensively studied bisphenol A (BPA), a prevalent environmental pollutant and contaminant of both water and foodstuffs. BPA has a significantly negative impact on human health, particularly on the regulation mechanisms of reproduction, and influences fertility. The ever increasingly stringent restriction of the industrial production of BPA is leading to its replacement with analogues, primarily with bisphenol S (BPS), which is not subject to these restrictions and whose impacts on the regulation of reproduction have not yet been exhaustively studied. However, the limited number of studies at disposal indicates that BPS may be at least as harmful as BPA. There is therefore a potential danger that the replacement of BPA with BPS will become one of the cases of regrettable substitution, in which the newly used substances manifest similar or even worse negative effects than the substances which they have replaced. The objective of this review is to draw attention to ill-advised replacements of endocrine disruptors with substances whose effects are not yet tested, and which may represent the same risks for the environment, for the reproduction of males and females, and for human health as have been demonstrated in the case of the originally used substances.

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“…In vitro studies have shown that BPA has the ability to bind to thyroid hormone receptors (35) and human studies have observed associations between higher BPA levels and altered levels of thyroid hormones (36)(37)(38)(39)(40) . Thyroid hormones regulate basal metabolism and the impact of even small alterations to thyroid hormone levels on body composition is evidenced by weight changes in patients with thyroid dysfunction (41)(42)(43) .…”

mentioning

confidence: 99%

Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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Objective: To review the literature on bisphenol A (BPA) exposure and obesity in human populations. Design: Systematic review of the literature via searches of PubMed, EMBASE, Web of Science and reference lists for articles published to 1 August 2014. Setting: China, Italy, Japan, Republic of Korea, Sweden, UK, USA. Subjects: Adults (≥18 years). Results: Eighteen articles were identified and included in the review. Twelve studies included secondary evaluations of BPA exposure and BMI, and six studies evaluated body composition as the primary outcome. All analyses were crosssectional and no study included in the review received a positive quality rating (twelve negative, six neutral). Eight studies observed a statistically significant positive association between urinary or serum BPA levels and BMI, and ten studies observed no association. Studies where BMI was a primary outcome and studies of neutral quality were more likely to observe an association. Conclusions: Study results are conflicting and significant methodological issues limit the ability to draw conclusions from these studies. Prospective studies that measure BPA exposure and changes in body weight and composition are needed to establish temporality, causality and the direction of any observed associations.

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High urinary bisphenol A concentrations in workers and possible laboratory abnormalities

Abstract: Higher occupational BPA exposure, reflected in urinary concentrations of BPA, may be associated with thyroid hormone disruption.

Cited by 80 publications

References 26 publications

Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements

Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Bisphenol A exposure and associations with obesity among adults: a critical review

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High urinary bisphenol A concentrations in workers and possible laboratory abnormalities

Abstract: Higher occupational BPA exposure, reflected in urinary concentrations of BPA, may be associated with thyroid hormone disruption.

Cited by 80 publications

References 26 publications

Bisphenol A Inhibits Voltage-Activated Ca2+ Channels in Vitro: Mechanisms and Structural Requirements

Bisphenol A Inhibits Voltage-Activated Ca2+ Channels in Vitro: Mechanisms and Structural Requirements

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Bisphenol A exposure and associations with obesity among adults: a critical review

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Product

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Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements

Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements