Higher defibrillation threshold in methamphetamine cardiomyopathy patients with implantable cardioverter-defibrillator

Malhotra, Rakesh; Patel, Shyam A.; Ramchand, Tekchand; Nimri, Omar Al

doi:10.1016/j.ipej.2017.07.002

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…Compared with age and sex-matched controls, methamphetamine-associated cardiomyopathy patients receiving ICDs had a defibrillation threshold almost 10 Joules higher. 117 Similarly, studies comparing chronic cocaine users to control patients showed up to 13 joules higher defibrillation threshold in cocaine users receiving ICDs. 118,119 We observed a direct time-dependent correlation between cocaine use and failed ICD therapies.…”

Section: The Ethics Of Defibrillator Use In Patients With Stimulant U...mentioning

confidence: 98%

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Dominic

Ahmad

Awwab

et al. 2022

Circ: Arrhythmia and Electrophysiology

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Nonmedical use of prescription and nonprescription drugs is a worldwide epidemic, rapidly growing in magnitude with deaths because of overdose and chronic use. A vast majority of these drugs are stimulants that have various effects on the cardiovascular system including the cardiac rhythm. Drugs, like cocaine and methamphetamine, have measured effects on the conduction system and through several direct and indirect pathways, utilizing multiple second messenger systems, change the structural and electrical substrate of the heart, thereby promoting cardiac dysrhythmias. Substituted amphetamines and cocaine affect the expression and activation kinetics of multiple ion channels and calcium signaling proteins resulting in EKG changes, and atrial and ventricular brady and tachyarrhythmias. Preexisting conditions cause substrate changes in the heart, which decrease the threshold for such drug-induced cardiac arrhythmias. The treatment of cardiac arrhythmias in patients who take drugs of abuse may be specialized and will require an understanding of the unique underlying mechanisms and necessitates a multidisciplinary approach. The use of primary or secondary prevention defibrillators in drug abusers with chronic systolic heart failure is both sensitive and controversial. This review provides a broad overview of cardiac arrhythmias associated with stimulant substance abuse and their management.

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Section: The Ethics Of Defibrillator Use In Patients With Stimulant U...mentioning

confidence: 98%

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Dominic

Ahmad

Awwab

et al. 2022

Circ: Arrhythmia and Electrophysiology

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“…This might explain the higher prevalence of malignant heart rhythm disorders like ventricular tachycardia or torsades de pointes . Furthermore, fibrosis is most likely responsible for an increase in shock impedance in patients with an implantable cardioverter‐defibrillator …”

Section: Cardiac Complicationsmentioning

confidence: 99%

Methamphetamine‐related cardiovascular diseases

2020

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Aims Abuse of crystal methamphetamine (MA) poses a growing problem for health services worldwide. This review summarizes the current literature on the effects of MA on the cardiovascular system. Methods and results This article is a presentation of a case report and review of the current literature. In Europe, especially the eastern countries and the eastern states of Germany are affected. MA increases the concentration of catecholamines in the synaptic gap leading to euphoria, alertness, and hunger suppression as well as psychiatric and gastrointestinal complications. MA consumption is associated with hypertension, acute and chronic myocardial toxicity, stroke, coronary artery disease, and sudden cardiac death. Although many aspects of the underlying pathophysiology remain unknown, catecholaminemediated pathologies appear to play an important role. The duration of MA consumption is the most important determinant for the prognosis. Conclusions Awareness is needed as cardiac complications are important causes of morbidity and mortality in patients with MA consumption. Drug abstinence is the mainstay of therapy, cardiac and other complications should be treated according to the respective guidelines. Incompliance to therapy and frequent relapses are the main challenges for successful treatment. Further research is required to improve the understanding of this rapidly increasing cardiomyopathy.

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Stimulant Use Disorder

Reinaker,

Johnson

2024

Substance Use Disorders in Adult Critically Ill Patients

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Higher defibrillation threshold in methamphetamine cardiomyopathy patients with implantable cardioverter-defibrillator

Cited by 5 publications

References 22 publications

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Methamphetamine‐related cardiovascular diseases

Stimulant Use Disorder

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