Higher Glutamate + Glutamine and Reduction of N-acetylaspartate in Posterior Cingulate According to Age Range in Patients with Cognitive Impairment and/or Pain

Fayed, Nicolás; Andrés, Eva; Viguera, Laura; Modrego, Pedro J.; Campayo, Javier García

doi:10.1016/j.acra.2014.04.009

Cited by 49 publications

(34 citation statements)

References 52 publications

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“…One study reported higher (Chiu et al, 2014) and one study lower (Fayed et al, 2014) age-associated NAA, and three other studies (Robertson et al, 2001, Chang et al, 2009, Reyngoudt et al, 2012) did not find a significant difference. Higher mIns (Reyngoudt et al, 2012, Fayed et al, 2014) and lower Glu (Chang et al, 2009, Fayed et al, 2014) have also been reported in the PCC in older adults. In summary, age-associated differences in NAA concentration in the PCC are controversial, and only a few studies have reported differences in tCr, tCho, mIns, and Glu.…”

Section: Introductionmentioning

confidence: 79%

“…Three studies reported higher tCho concentration in older adults (Robertson et al, 2001, Chiu et al, 2014, Fayed et al, 2014), while two did not find a significant difference (Chang et al, 2009, Reyngoudt et al, 2012). For tCr, two studies reported higher concentration in older adults (Reyngoudt et al, 2012, Chiu et al, 2014), while two did not find a difference (Robertson et al, 2001, Chang et al, 2009).…”

Section: Introductionmentioning

confidence: 88%

“…In the PCC, NAA, total Cr (tCr = Cr + PCr), and choline containing compounds (tCho = GPC + PCho) have been measured in the context of aging using 1 H MRS in several studies (Robertson et al, 2001, Chang et al, 2009, Reyngoudt et al, 2012, Chiu et al, 2014, Fayed et al, 2014). Three studies reported higher tCho concentration in older adults (Robertson et al, 2001, Chiu et al, 2014, Fayed et al, 2014), while two did not find a significant difference (Chang et al, 2009, Reyngoudt et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1 H magnetic resonance spectroscopy at 7 T

et al. 2017

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The concentrations of fourteen neurochemicals associated with metabolism, neurotransmission, antioxidant capacity, and cellular structure were measured noninvasively from two distinct brain regions using 1H magnetic resonance spectroscopy. Seventeen young adults (age 19 – 22 years) and sixteen cognitively normal older adults (age 70 – 88 years) were scanned. To increase sensitivity and specificity, 1H magnetic resonance spectra were obtained at the ultra-high field of 7 T and at ultra-short echo time. The concentrations of neurochemicals were determined using water as an internal reference and accounting for gray matter, white matter, and cerebrospinal fluid content of the volume of interest. In the posterior cingulate cortex (PCC), the concentrations of neurochemicals associated with energy (i.e., creatine plus phosphocreatine), membrane turnover (i.e., choline containing compounds), and gliosis (i.e., myo-inositol) were higher in the older adults while the concentrations of N-acetylaspartylglutamate (NAAG) and phosphorylethanolamine (PE) were lower. In the occipital cortex (OCC), the concentration of N-acetylaspartate (NAA), a marker of neuronal viability, concentrations of the neurotransmitters Glu and NAAG, antioxidant ascorbate (Asc), and PE were lower in the older adults while the concentration of choline containing compounds was higher. Altogether, these findings shed light on how the human brain ages differently depending on region.

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1 H magnetic resonance spectroscopy at 7 T

et al. 2017

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“…It is well known that aging is associated with decreases in brain volume(58). This loss is not homogeneously distributed across the brain, with some regions demonstrating more decline in GM volume with aging than others, including pain regions(59).…”

Section: Discussionmentioning

confidence: 99%

Structural Brain Imaging in People With Low Back Pain

Mansour

Lepping

Honea

et al. 2017

Spine

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Study Design cross-sectional study Objective The aim of this study was to determine whether low back pain (subacute and chronic) is related to differences in brain volume. Summary of Background Data Inconsistent findings have been reported about the effect of chronic low back pain on brain volume, and the effect of subacute low back pain on brain volume has not been sufficiently investigated. Methods 130 participants were included (23 subacute and 68 chronic low back pain; 39 healthy controls). The main outcome measure was whole and regional brain volume. Clinical outcome measures included pain duration, pain intensity, fear avoidance belief questionnaire, Oswestry disability index, and Beck’s depression inventory. Results Decrease in brain volume in several regions was observed in chronic low back pain when compared to health subjects; however after correcting for multiple comparisons, no significant differences were detected between any of the 3 groups in whole-brain volume. Regionally, we detected less gray matter volume in 2 voxels in the middle frontal gyrus in chronic low back pain participants compared to healthy controls. None of the clinical outcome measures were correlated with brain volume measurements. Conclusion Low back pain (subacute or chronic) is not related to significant differences in brain volume after correction for multiple comparisons. The effect size was too small to detect possible subtle changes unless much larger sample sizes are examined, or it is possible that low back pain does not affect brain volume.

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“…By evaluating neural networks, cerebral blood perfusion, neural metabolites and quantified integrity of fiber tracts in the brain, fMRI may provide insight into the visualization of mental illness and ultimately advancing the diagnostic capabilities of the brain and various treatments far beyond what is currently available [40,42,43].…”

Section: Proposed Methods Of Assessing Scientifically Before and Aftermentioning

confidence: 99%

Holographic Kinetics for Clinically Diagnosed Suicidal, Depressed, PTSD Military Veterans: Case Study

Chevalier¹

2017

ACIM

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Higher Glutamate + Glutamine and Reduction of N-acetylaspartate in Posterior Cingulate According to Age Range in Patients with Cognitive Impairment and/or Pain

Cited by 49 publications

References 52 publications

Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1 H magnetic resonance spectroscopy at 7 T

Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using 1 H magnetic resonance spectroscopy at 7 T

Structural Brain Imaging in People With Low Back Pain

Holographic Kinetics for Clinically Diagnosed Suicidal, Depressed, PTSD Military Veterans: Case Study

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