Higher Natriuretic Peptide Levels Associate With a Favorable Adipose Tissue Distribution Profile

Neeland, Ian J.; Winders, Benjamin R.; Ayers, Colby; Das, Sandeep R; Chang, Alice Y.W.; Berry, Jarett D.; Khera, Amit; McGuire, Darren K.; Vega, Gloria Lena; Lemos, James A. de; Turer, Aslan T.

doi:10.1016/j.jacc.2013.03.038

Cited by 110 publications

(90 citation statements)

References 45 publications

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“…In a prospective study, low plasma levels of ANP were found to predict development of future diabetes, suggesting a causal role of ANP deficiency in diabetes development 103. In another study, higher NP levels were associated with a favorable body‐fat profile, including lower visceral fat and reduced insulin resistance 104. In a follow‐up study, higher NP levels were associated with reduced risk for diabetes 105…”

Section: Natriuretic Peptides In the Regulation Of Energy Metabolismmentioning

confidence: 99%

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events

Kerkelä

Ulvila

Magga

2015

JAHA

131

108

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Section: Natriuretic Peptides In the Regulation Of Energy Metabolismmentioning

confidence: 99%

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events

Kerkelä

Ulvila

Magga

2015

JAHA

131

108

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“…There also is evidence that a reduction in NP levels is associated to a less favorable adipose tissue distribution profile. Recent data from the Dallas Heart Study show that both BNP and NT-proBNP are inversely associated with visceral and liver fat and positively associated with lower glutofemoral body fat, independent of confounders including insulin resistance (53).…”

Section: Nps and Obesity Diabetes And Diabetes Complications Obesitymentioning

confidence: 99%

Natriuretic Peptides, Heart, and Adipose Tissue: New Findings and Future Developments for Diabetes Research

2014

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Natriuretic peptides (NPs) play a key role in cardiovascular homeostasis, counteracting the deleterious effects of volume and pressure overload and activating antibrotic and antihypertrophic pathways in the heart. N-terminal B-type NP (NT-proBNP) also is a promising biomarker of global cardiovascular risk in the general population, and there is increasing interest on its potential use in diabetic patients for screening of silent cardiovascular abnormalities, cardiovascular risk stratification, and guided intervention. Recently, both atrial NP (ANP) and B-type NP (BNP) have emerged as key mediators in the control of metabolic processes including the heart in the network of organs that regulate energy usage and metabolism. Epidemiological studies have shown that ANP and BNP are reduced in people with obesity, insulin resistance, and diabetes, and this deficiency may contribute to enhance their global cardiovascular risk. Moreover, ANP and BNP have receptors in the adipose tissue, enhance lipolysis and energy expenditure, and modulate adipokine release and food intake. Therefore, low ANP and BNP levels may be not only a consequence but also a cause of obesity, and recent prospective studies have shown that low levels of NT-proBNP and midregional proANP (MR-proANP) are a strong predictor of type 2 diabetes onset. Whether ANP and BNP supplementation may result in either cardiovascular or metabolic benefits in humans remains, however, to be established.Natriuretic peptides (NPs) have gained great interest as indicators of the state of cardiovascular health across the spectrum of cardiovascular diseases (CVD) in diabetic subjects (1-4). Recently, NPs also have emerged as key mediators in the control of metabolic processes (5) and have been implicated in the development of diabetes (6,7), shifting current paradigms and opening novel avenues in diabetes research. This review will summarize new findings in the field and discuss their potential clinical relevance. NPS AND THEIR RECEPTORSNPs are a family of genetically distinct and structurally related peptides, including atrial NP (ANP), B-type NP (BNP), and C-type NP (CNP). They share a similar structural conformation, characterized by a peptide ring with a cysteine bridge, which is well preserved throughout evolution, being the portion of the chain that binds to the receptor. ANP and BNP are predominantly secreted by cardiomyocytes, whereas CNP is mainly produced by the central nervous system, the endothelium, the bone, and the reproductive system (8-11).

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“…4 VAT is highly metabolically active and produces a variety of substances, for example interleukin-6 (IL-6), which contributes to low-grade inflammation and insulin resistance. 5,6 Furthermore, increased VAT has been associated with the activation of the sympathetic nervous system 7,8 and lower circulating concentrations of natriuretic peptides (NPs), 9,10 which could contribute to hypertension in individuals with increased VAT.…”

mentioning

confidence: 99%

Abdominal Adiposity Distribution Quantified by Ultrasound Imaging and Incident Hypertension in a General Population

et al. 2016

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Abstract-Abdominal obesity is a major risk factor for hypertension. However, different distributions of abdominal adipose tissue may affect hypertension risk differently. The main purpose of this study was to explore the association of subcutaneous abdominal adipose tissue (SAT) and visceral adipose tissue (VAT) with incident hypertension in a population-based setting. We hypothesized that VAT, rather than SAT, would be associated with incident hypertension. VAT and SAT were determined by ultrasound imagining in 3363 randomly selected Danes (mean age 49 years, 56% women, mean body mass index 25.8 kg/m 2 ). We constructed multiple logistic regression models to compute standardized odds ratios with 95% confidence intervals per SD increase in SAT and VAT. Of the 2119 normotensive participants at baseline, 1432, with mean SAT of 2.8 cm and mean VAT of 5.7 cm, returned 5 years later for a follow-up examination and among them 203 had developed hypertension. In models including both VAT and SAT, the Framingham Hypertension Risk Score variables (age, sex, smoking status, family history of hypertension, and baseline blood pressure) and glycated hemoglobin, odds ratio (95% confidence interval) for incident hypertension for 1 SD increase in VAT and SAT was 1.27 (1.08-1.50, P=0.004) and 0.97 (0.81-1.15, P=0.70), respectively. Adjusting for body mass index instead of SAT attenuated the association between VAT and incident hypertension, but it was still significant (odds ratio, 1.22 [1.01-1.48, P=0.041] for each SD increase in VAT). In conclusion, ultrasound-determined VAT, but not SAT, was associated with incident hypertension in a random sample of Danish adults.

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Higher Natriuretic Peptide Levels Associate With a Favorable Adipose Tissue Distribution Profile

Cited by 110 publications

References 45 publications

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events

Natriuretic Peptides, Heart, and Adipose Tissue: New Findings and Future Developments for Diabetes Research

Abdominal Adiposity Distribution Quantified by Ultrasound Imaging and Incident Hypertension in a General Population

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