Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes

Puppione, Donald L.

doi:10.1016/j.cbd.2014.08.001

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…We also looked for other independent studies to support the existence of our subparticle candidates. One example is the apoA-I, apoC-I, and apoE complex. , It has been reported that apoC-I binds free fatty acids and reduces their intracellular esterification, and its function to modulate the interaction of apoE and beta-migrating VLDL . At the same time, apoE and apoA-I binding to ATP-binding cassette, subfamily A member 1 (ABCA1) is essential for the HDL formation .…”

Section: Resultsmentioning

confidence: 99%

“…37,38 It has been reported that apoC-I binds free fatty acids and reduces their intracellular esterification, and its function to modulate the interaction of apoE and beta-migrating VLDL. 39 At the same time, apoE and apoA-I binding to ATP-binding cassette, subfamily A member 1 (ABCA1) is essential for the HDL formation. 40 ApoA-I mainly works in the cholesterol efflux process, and many studies have supported the idea that apoC-I and apoE may work together with apoA-I to help with lipid metabolism.…”

Section: Each Of the Putative Hdl Subspecies Has At Least Two Literat...mentioning

confidence: 99%

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Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes

Gordon

Zhu

et al. 2015

J. Proteome Res.

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High density lipoprotein (HDL) particles are blood-borne complexes whose plasma levels have been associated with protection from cardiovascular disease (CVD). Recent studies have demonstrated the existence of distinct HDL subspecies; however, these have been difficult to isolate and characterize biochemically. Here, we present the first report that employs a network-based approach to systematically infer HDL subspecies. Healthy human plasma was separated into 58 fractions using our previously published three orthogonal chromatography techniques. Similar local migration patterns among HDL proteins were captured with a novel similarity score, and individual comigration networks were constructed for each fraction. By employing a graph mining algorithm, we identified 183 overlapped cliques, among which 38 were further selected as candidate HDL subparticles. Each of these 38 subparticles had at least two literature supports. In addition, GO function enrichment analysis showed that they were enriched with fundamental biological and CVD protective functions. Furthermore, gene knockout experiments in mouse model supported the validity of these subparticles related to three apolipoproteins. Finally, analysis of an apoA-I deficient human patient's plasma provided additional support for apoA-I related complexes. Further biochemical characterization of these putative subspecies may facilitate the mechanistic research of CVD and guide targeted therapeutics aimed at its mitigation.

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Section: Resultsmentioning

confidence: 99%

Section: Each Of the Putative Hdl Subspecies Has At Least Two Literat...mentioning

confidence: 99%

Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes

Gordon

Zhu

et al. 2015

J. Proteome Res.

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“…APOC1, the smallest apolipoprotein (only 6.6 KDa), is a component of both triglyceride-rich lipoproteins and high-density lipoproteins. 9 Previous studies have shown that APOC1 contributes to lipid transport and metabolism in serum and plasma. 10,13 Interesting, emerging researches highlight the relationship between APOC1 and cancers.…”

Section: Discussionmentioning

confidence: 99%

“…8 Apolipoprotein C-1(APOC1), located on chromosome 19, is the smallest of all apolipoproteins (only 6.6 kDa) which can be found within HDL or VLDL. 9 Previous studies have shown that APOC1 contributes to lipid transport and metabolism in serum and plasma by binding to free lipids to form lipoprotein and transport lipids through the lymphatic and circulatory systems. 10 Interestingly, recent studies have shown that the deregulation of APOC1 are detected in some malignancies including breast, gastric and prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

APOC1 is a Potential Prognostic Biomarker and Correlated With Immune Infiltration in ESCC

Xie¹,

Liu²,

Luo³

et al. 2020

Preprint

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PurposeEsophageal cancer (EC) is the sixth leading cause of cancer death worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant subtype of EC. Identifying diagnostic biomarkers for ESCC is necessary for cancer practice. Increasing evidence illustrates that apolipoprotein C-1 (APOC1) participates in the carcinogenesis. However, the biological function of APOC1 in ESCC remains unclear. Patients and methodsWe investigated the expression level of APOC1 using TIMER2.0 and GEO databases, the prognostic value of APOC1 in ESCC using Kaplan-Meier plotter and TCGA databases. We used LinkedOmics to identify co-expressed genes with APOC1 and perform GO and KEGG pathway analysis. The target networks of kinases, miRNAs and transcription factors were predicted by gene set enrichment analysis (GSEA). The correlations between APOC1 and immune infiltration were calculated using TIMER2.0 and CIBERSORT databases. We further performed the prognostic analysis based on APOC1 expression levels in related immune cells subgroups via Kaplan-Meier plotter database. ResultsAPOC1 was found overexpressed in tumor tissues in multiple ESCC cohorts and high APOC1 expression was related to a dismal prognosis. Multivariate analysis confirmed that APOC1 overexpression was an independent indicator of poor OS. Functional network analysis indicated that APOC1 might regulate the natural killer cell mediated cytotoxicity, phagosome, AMPK and hippo signaling through pathways involving some cancer-related kinases, miRNA and transcription factors. Immune infiltration analysis showed that APOC1 was significantly positively correlated with M0 macrophages cells, M1 macrophages cells and activated NK cells, negatively correlated with regulatory T cells, CD8 T cells, neutrophils and monocytes. High APOC1 expression had a poor prognosis in server immune cells subgroups in ESCC, including decreased CD8+ T cells subgroups. ConclusionThese findings suggest that increased expression of APOC1 is related to poor prognosis and immune infiltration in ESCC. APOC1 holds promise for serving as a valuable diagnostic and prognostic marker in ESCC.

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“…Apolipoprotein C-I (apoC-I) is a small soluble lipoprotein that can be found within HDL or VLDL (1). The gene encoding apoC-I is located in chromosome 19 along with the genes for apoE, apoC-IV and apoC-II (2).…”

Section: Introductionmentioning

confidence: 99%

Truncated apolipoprotein C-I induces apoptosis in neuroblastoma by activating caspases in the extrinsic and intrinsic pathways

et al. 2017

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Truncated apolipoprotein C-I is a post-translationally modified protein characterized by the loss of threonine and proline residues from the N-terminus of the mature peptide. The truncated peptide is involved in many physiological and pathological processes in vivo and is related to malignant diseases. The aim of the present study was to assess the effects of the truncated peptide on tumorigenesis in neuroblastoma. The truncated peptide was chemically synthesized, and a signal peptide was used as the negative control. The results of the CCK-8 assay showed that the truncated peptide selectively inhibited cell proliferation compared with the signal peptide, and inhibited migration and invasion as determined by wound healing and Transwell assays. Flow cytometry analysis demonstrated that the truncated peptide induced apoptosis and cell cycle arrest in the S phase. Bax, Bim, and tBid upregulation, and Bcl‑2 and Bcl‑xl downregulation were associated with permeabilization of the mitochondrial membrane, as detected by the JC-1 assay and the release of cytochrome c and apoptosis. Activation of caspase‑8 was associated with activation of cell death receptors such as the tumor necrosis factor receptor. PARP cleavage indicated apoptosis, and DNA damage was observed in the TUNEL assay. The results showed that the truncated apoC-I induced apoptosis in neuroblastoma by the extrinsic and intrinsic pathways. The anticancer effects were confirmed in vivo in a xenograft mouse model. In conclusion, the endogenous protein apoC-I may be a new promising therapeutic target to suppress tumor growth.

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Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes

Cited by 4 publications

References 18 publications

Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes

Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes

APOC1 is a Potential Prognostic Biomarker and Correlated With Immune Infiltration in ESCC

Truncated apolipoprotein C-I induces apoptosis in neuroblastoma by activating caspases in the extrinsic and intrinsic pathways

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