Higher Sensitivity and Specificity for Diffusion-weighted Imaging of Malignant Lung Lesions without Apparent Diffusion Coefficient Quantification

Uto, Tomohiro; Takehara, Yasuo; Nakamura, Yutaro; Naito, Tateaki; Dai, Huaping; Inui, Naoki; Suda, Takafumi; Nakamura, Hirotoshi; Chida, Kingo

doi:10.1148/radiol.2521081195

Cited by 140 publications

(175 citation statements)

References 29 publications

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“…Furthermore, misregistration between images with different b-values because of patient motion or image distortion may impair the reliability of ADC measurements. To overcome the limitations of the ADC, a so-called lesion-to-spinal cord ratio (LSR) was recently introduced, which is a semiquantitative measure that represents the ratio of lesion signal intensity to spinal cord signal intensity (18). The LSR takes into account both diffusion and T2 relaxation time, does not suffer from image misregistration issues, and has been shown to outperform the ADC in differentiating lung cancer from benign lesions (18).…”

Section: Development Of Dwi: From the Brain To The Entire Bodymentioning

confidence: 99%

“…To overcome the limitations of the ADC, a so-called lesion-to-spinal cord ratio (LSR) was recently introduced, which is a semiquantitative measure that represents the ratio of lesion signal intensity to spinal cord signal intensity (18). The LSR takes into account both diffusion and T2 relaxation time, does not suffer from image misregistration issues, and has been shown to outperform the ADC in differentiating lung cancer from benign lesions (18). The LSR or a similar measure has the potential to replace or complement the ADC for the characterization of lesions.…”

Section: Development Of Dwi: From the Brain To The Entire Bodymentioning

confidence: 99%

“…The contribution of 18 F-FDG PET to medicine has been unmatched by any other functional imaging modality (4). At present, there is also growing interest in the application of diffusion-weighted MRI (DWI) in the body (5)(6)(7).…”

mentioning

confidence: 99%

“…DWI allows visualization and quantification of the mobility of water molecules and has many potential clinical applications. Importantly, although 18 F-FDG PET and DWI are both functional imaging modalities and provide a high lesion-to-background contrast, they are based on completely different biophysical and biochemical underpinnings. Therefore, the information provided by the 2 imaging modalities may be regarded as complementary.…”

mentioning

confidence: 99%

“…This article will review the basic principles, clinical applications, and limitations of DWI. Furthermore, the available evidence that correlates and compares 18 F-FDG PET with DWI will be reviewed.…”

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confidence: 99%

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Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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18 F-FDG PET is an established functional imaging modality for the evaluation of human disease. Diffusion-weighted MRI (DWI) is another rapidly evolving functional imaging modality that can be used to evaluate oncologic and nononcologic lesions throughout the body. The information provided by 18 F-FDG PET and DWI can be complementary, because the 2 methods are based on completely different biophysical underpinnings. This article will describe the basic principles, clinical applications, and limitations of DWI. In addition, the available evidence that correlates and compares 18 F-FDG PET and DWI will be reviewed. PET,usi ng the radiotracer 18 F-FDG, is an established functional imaging modality for a variety of oncologic and nononcologic (e.g., inflammatory and infectious) applications (1-3). The contribution of 18 F-FDG PET to medicine has been unmatched by any other functional imaging modality (4). At present, there is also growing interest in the application of diffusion-weighted MRI (DWI) in the body (5-7). DWI allows visualization and quantification of the mobility of water molecules and has many potential clinical applications. Importantly, although 18 F-FDG PET and DWI are both functional imaging modalities and provide a high lesion-to-background contrast, they are based on completely different biophysical and biochemical underpinnings. Therefore, the information provided by the 2 imaging modalities may be regarded as complementary. Given the developing applications of DWI, the increasing use of multimodality imaging (8), and the expected advent of fully integrated PET/MRI systems (9), knowledge of the characteristics, possibilities, and limitations of DWI technique is becoming increasingly important. This is true for both the imaging specialists and the clinicians who use these modalities. This article will review the basic principles, clinical applications, and limitations of DWI. Furthermore, the available evidence that correlates and compares 18 F-FDG PET with DWI will be reviewed.

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Section: Development Of Dwi: From the Brain To The Entire Bodymentioning

confidence: 99%

Section: Development Of Dwi: From the Brain To The Entire Bodymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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Diffusion‐weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm

Ogawa

Horaguchi

Fujita

et al. 2014

J Hepato Biliary Pancreat

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Recent technological and application developments in computed tomography and magnetic resonance imaging for improved pulmonary nodule detection and lung cancer staging

Sieren

Ohno

Koyama

et al. 2010

Magnetic Resonance Imaging

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This review compares the emerging technologies and approaches in the application of magnetic resonance (MR) and computed tomography (CT) imaging for the assessment of pulmonary nodules and staging of malignant findings. Included in this review is a brief definition of pulmonary nodules and an introduction to the challenges faced. We have highlighted the current status of both MR and CT for the early detection of lung nodules. Developments are detailed in this review for the management of pulmonary nodules using advanced imaging, including: dynamic imaging studies, dual energy CT, computer aided detection and diagnosis, and imaging assisted nodule biopsy approaches which have improved lung nodule detection and diagnosis rates. Recent advancements linking in vivo imaging to corresponding histological pathology are also highlighted. In vivo imaging plays a pivotal role in the clinical staging of pulmonary nodules through TNM assessment. While CT and positron emission tomography (PET)/CT are currently the most commonly clinically employed modalities for pulmonary nodule staging, studies are presented that highlight the augmentative potential of MR. LUNG CANCER remains a challenging disease to effectively identify, diagnose, and treat, as reflected by the 5-year survival rate, which remains similar to that of 15 years ago at 13%. Lung cancer frequently manifests as a peripheral lung nodule or mass. Radiologically identified lesions in the lung that are less than 30 mm in diameter are defined as pulmonary nodules, while those greater than 30 mm are termed masses (1). Both pulmonary nodules and masses present specific challenges in the evaluation of suspected lung cancer; however, the greatest impact of x-ray computed tomography (CT) and magnetic resonance imaging (MRI) developments have been on the detection and characterization of pulmonary nodules. Hence, the scope of this review will focus on the recent advances in CT and MRI of pulmonary nodules and lung cancer staging, highlighting the respective strengths and weaknesses of these modalities. X-ray chest radiography (CXR) is the most widely utilized modality for pulmonary abnormalities and disease screening, although sonography has been utilized in limited situations in the chest. In addition, positron emission tomography (PET) or PET/CT with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) is currently widely utilized for differentiation of malignant lesions from benign lesions, staging of malignant tumors, and assessment of therapeutic effects after conservative therapy. The value of CT and MR for depicting structural anatomy is widely appreciated and applied clinically to noninvasively identify abnormalities and/ or disease. Recent developments of imaging techniques and processing have expanded the potential of these modalities to include combined structure and function. Recent exciting work for the detection, monitoring, characterization, and staging of pulmonary cancer nodules using imaging of both CT and MR modalities will be summarized in this review.While the overall...

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Higher Sensitivity and Specificity for Diffusion-weighted Imaging of Malignant Lung Lesions without Apparent Diffusion Coefficient Quantification

Abstract: LSR measurement on high-b value DW imaging may be useful for differentiating between benign and malignant lung nodules.

Cited by 140 publications

References 29 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Diffusion‐weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm

Recent technological and application developments in computed tomography and magnetic resonance imaging for improved pulmonary nodule detection and lung cancer staging

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Higher Sensitivity and Specificity for Diffusion-weighted Imaging of Malignant Lung Lesions without Apparent Diffusion Coefficient Quantification

Abstract: LSR measurement on high-b value DW imaging may be useful for differentiating between benign and malignant lung nodules.

Cited by 140 publications

References 29 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Diffusion‐weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm

Recent technological and application developments in computed tomography and magnetic resonance imaging for improved pulmonary nodule detection and lung cancer staging

Contact Info

Product

Resources

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Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications