Highlight report: mitochondrial depolarization by ethanol

Drug-induced mitochondrial impairment in liver cells

“…Drug or chemically induced liver injury represents a cutting-edge topic in toxicology (Benet et al, 2014[ 1 ]; Campos et al, 2014[ 2 ]; Vitins et al, 2014[ 25 ]; Liu et al, 2014[ 16 ]; Godoy and Bolt, 2012[ 6 ]; Vinken et al, 2012[ 24 ]; Liang et al, 2011[ 15 ]; Hammad et al, 2011[ 11 ]). Numerous research projects aim at establishing in vitro systems to predict human hepatotoxicity (Chen et al, 2014[ 4 ]; Grinberg et al, 2014[ 10 ]; Carvalho et al, 2004[ 3 ]; O'Brien et al, 2006[ 17 ]; Reif, 2015[ 19 ]; Shinde et al, 2015[ 21 ][ 22 ]; Kim et al, 2015[ 14 ]; Pfeiffer et al, 2015[ 18 ]). One of the limitations of current research is that it still remains challenging to predict doses that are associated with an increased risk of hepatotoxicity in vivo (Ghallab, 2013[ 5 ]; Reif, 2014[ 20 ]).…”