Highlighting the Compositional Changes of the Sm2O3/MgO-Containing Cellulose Acetate Films for Wound Dressings

Abstract

The development of wound dressing materials with appropriate specifications is still a challenge to overcome the current limitations of conventional medical bandages. In this regard, simple and fast methods are highly recommended, such as film casting. In addition, deliverable nanoparticles that can act to accelerate wound integration, such as samarium oxide (Sm2O3) and magnesium oxide (MgO), might represent a potential design with a novel compositional combination. In the present research, the casted film of cellulose acetate (CA) was mixed with different ratios of metal oxides, such as samarium oxide (Sm2O3) and magnesium oxide (MgO). The tests used for the film examination were X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The SEM graphs of CA films represent the surface morphology of Sm2O3@CA, MgO@CA, and Sm2O3/MgO/GO@CA. It was found that the scaffolds’ surface contained a high porosity ratio with diameters of 1.5–5 µm. On the other hand, the measurement of contact angle exhibits a variable trend starting from 27° to 29° for pristine CA and Sm2O3/MgO/GO@CA. The cell viability test exhibits a noticeable increase in cell growth with a decrease in the concentration. In addition, the IC50 was determined at 6 mg/mL, while the concentration of scaffolds of 20 mg/mL caused cellular growth to be around 106%.

Enhanced Antibacterial Activity in Cellulose Acetate Films with Surface Defect-Rich MgO Nanoparticles for Sustainable Active Packaging Applications

“…FTIR spectra of the three CA films are shown in Figure S2B. The neat CA film showed characteristic peaks at 1733, 1369, 1222, 1032, and 903 cm –1 which were respectively ascribed to stretching vibrations of carbonyl functional groups (−CO), methyl bending (C–CH 3 ), alkoxyl stretching of the ester (C–O–C), the C–O functional group, and C–OH stretching . The presence of MgO NPs in the CA film was detected by absorption peaks at 547 and 3700 cm –1 , representing Mg–O–Mg stretching and isolated OH vibrations.…”

“…FTIR spectra of the three CA films are shown in Figure S2B. The neat CA film showed characteristic peaks at 1733, 1369, 1222, 1032, and 903 cm −1 which were respectively ascribed to stretching vibrations of carbonyl functional groups (−C�O), 57 The presence of MgO NPs in the CA film was detected by absorption peaks at 547 and 3700 cm −1 , representing Mg−O− Mg stretching and isolated OH vibrations. Interestingly, the appearance of chemically adsorbed OH was observed in the asprepared MgO NP-incorporated film, but not in their original form.…”

Improving the Durability of Chitosan Films through Incorporation of Magnesium, Tungsten, and Graphene Oxides for Biomedical Applications

“…[8,12] Due to their ability to replicate the extracellular matrix and create an environment conducive to proliferation and cell growth, tissue engineering frameworks have been extensively used in this field. [13,14] Chitin, a structural biopolymer found in the exoskeletons of several crustaceans and mollusks, is converted into chitosan (CS), a biodegradable polysaccharide. Chitosan is frequently regarded as biocompatible, non-antigenic, non-toxic, and bioabsorbable.…”

“…Effective polymeric dressings for treating chronic ulcers are currently in higher demand than ever [8,12] . Due to their ability to replicate the extracellular matrix and create an environment conducive to proliferation and cell growth, tissue engineering frameworks have been extensively used in this field [13,14] …”

Magnesium Ortho-Vanadate/Magnesium Oxide/Graphene Oxide Embedded through Cellulose Acetate-Based Films for Wound Healing Applications

“…The three active hydroxyl groups/one molecule are dynamic in introducing cellulosic proper physicochemical features [19][20][21]. Additionally, cellulose esterification produces cellulose acetate, the most prevalent natural polysaccharide in the environment, a biodegradable thermoplastic polymer [22][23][24]. CA is a semi-synthetic, biocompatible polymer with convenient hydrophilicity, degradability, and moisture retention [25].…”