Highlights on the alternatives to antibiotic therapy against bacterial infection

Sircar, Bijayanta; Mandal, Shyamapada

doi:10.22270/jddt.v11i2.4596

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…Futhermore, antibiotic resistance in pathogenic bacteria is a global public health problem. Despite the development of new effective drugs, the speed of emergence of this drug resistance is more important than the frequency of discovery of new pharmacologically active molecules 29 . To challenge this problem, new investigations into the antimicrobial activity of synthetic molecules could contribute to strengthening the therapeutic arsenal to be used against emerging diseases.…”

Section: Figure 1: Molecular Structure Of Diazinesmentioning

confidence: 99%

Evaluation of antibacterial and antifungal activities of N-benzylthienopyrimidinone derivatives

DIEDHIOU

Baldé

Ndoye

et al. 2022

J. Drug Delivery Ther.

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This study is part of the biological investigation of the chemical library of molecules already described by the Laboratory of Organic Chemistry and Therapeutic Chemistry of the University of Bordeaux. The main objective was to explore the contribution of a thienyl moiety attached to the pyrimidinone nucleus, in the expression of an antimicrobial activity. The structural modifications mainly concerned the conservation or not of the benzo fragment attached to the thienyl, the saturation or not in position-1,2 of the pyrimidinone ring, the substitution on N-benzyl with more or less lipophilic units, the modification of the orientation of the thienyl fragment with, on the one hand, the compounds in which the sulfur is located near the N1 nitrogen (series of thieno[2,3-d]pyrimidin-4-ones) and on the other hand, compounds in which the sulfur is located near the ketone group (series of thieno[3,2-d]pyrimidin-4-ones). In general, thienyl fragment with sulfur located near the ketone group and the unsaturated pyrimidinone nucleus in the 1,2-position, seem to promote a broad spectrum of antibacterial activity, with compound 9c which is active on both Gram + bacteria and Gram – bacteria studied. The same pattern was observed for antifungal activity, which is maximum with the compounds of the thieno[3,2-d]pyrimidin-4-ones series for an MIC of 31.25 μg/ml on the strains of Candida albicans and Candida kruzei studied. Keywords: Thienopyrimidinones, antibacterial activity, antifungal activity.

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Section: Figure 1: Molecular Structure Of Diazinesmentioning

confidence: 99%

Evaluation of antibacterial and antifungal activities of N-benzylthienopyrimidinone derivatives

DIEDHIOU

Baldé

Ndoye

et al. 2022

J. Drug Delivery Ther.

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“…Moreover, medically-graded honey that is enriched with antimicrobial peptides has antibacterial activity against resistant strains of bacteria [83] . Alongside this, honey has been proven to be effective against some drug-resistant pathogens [84] . These findings suggest that honey is a potential alternative treatment for bacterial infections caused by E. coli and S. aureus.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activities of honey against Escherichia coli and Staphylococcus aureus: A potential treatment for bacterial infections and alternative to antibiotics

Mudenda¹,

Hikaambo²,

Chabalenge³

et al. 2023

J Pharmacogn Phytochem

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The global problem of antimicrobial resistance (AMR) has increased interest in natural products, such as honey in the treatment of diseases. This study evaluated the antibacterial activities of honey against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). This cross-sectional study was conducted from November 2020 to May 2021 using E. coli and S. aureus as indicator organisms. The antibacterial activities of honey were assessed using the agar well diffusion assay. The sensitivities of E. coli and S. aureus to honey were indicated by zones of inhibition which were measured using a ruler in millimetres. Data analysis was performed using Stata version 16.1. Honey produced a dose-dependent antibacterial activity against E. coli and S. aureus. Our study demonstrated that honey had stronger antibacterial activities against E. coli compared to S. aureus. This study highlights the need for further research on honey to investigate its potential use in treating bacterial infections.

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Highlights on the alternatives to antibiotic therapy against bacterial infection

Cited by 2 publications

References 56 publications

Evaluation of antibacterial and antifungal activities of N-benzylthienopyrimidinone derivatives

Evaluation of antibacterial and antifungal activities of N-benzylthienopyrimidinone derivatives

Antibacterial activities of honey against Escherichia coli and Staphylococcus aureus: A potential treatment for bacterial infections and alternative to antibiotics

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