Flexible pressure sensors have shown significant application prospects in fields such as artificial intelligence and precision manufacturing. However, most flexible pressure sensors are often prepared using polymer materials and precise micronano processing techniques, which greatly limits the widespread application of sensors. Here, this work chooses textile material as the construction material for the sensor, and its latitude and longitude structure endows the sensor with a natural structure. The flexible pressure sensor was designed using a multilayer stacking strategy by combining multilayer textile materials with two-dimensional MXene materials. The experiment shows that its sensitivity is 52.08 kPa −1 at 30 and 7.29 kPa −1 within 30−120 kPa. As a demonstration, these sensors are applied to wireless human motion monitoring, as well as related applications involving auxiliary communication and robotic arm integration. Furthermore, relevant demonstrations of sensor array applications are presented. This work provides inspiration for the design and application of flexible pressure sensors.