Highly efficient chiral separation of amlodipine enantiomers via triple recognition hollow fiber membrane extraction

Lai, Shenzhi; Tang, S. L.; Xie, Jiaqi; Cai, Changqun; Chen, Xiaoming; Chen, Chunyan

doi:10.1016/j.chroma.2017.02.018

Cited by 21 publications

(6 citation statements)

References 37 publications

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“…As an artificial identification system, molecular imprinting polymers (MIPs) are superior to the natural identification system in terms of low cost, long‐term stability, and resistance to harsh environments. [ 1,2 ] Generally, the preparation of MIPs includes the self‐assembly of template and functional monomers, polymerization under the action of initiator and cross‐linker, followed by extraction of template molecules to form specific recognition sites. [ 3,4 ] There are three main synthetic strategies for imprinting template molecules, including covalent, non‐covalent, and semi‐covalent approach.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances of Molecularly Imprinted Polymers Based on Cyclodextrin

Zhao

Wang

Zhang

et al. 2021

Macromol. Rapid Commun.

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Molecular imprinting polymers (MIPs), generally considered as artificial mimics that are comparable to natural receptor, are polymers with tailor‐made specific recognition sites complementary to the template molecules in shape and size. As a class of supramolecular compounds, cyclodextrins (CDs) are flourishing in the field of molecular imprinting with their unique structural properties. This review presents recent advances in application of MIPs based on CDs during the past five years. The discussion is grouped according to the different role of CDs in MIPs, that is, functional monomer, carrier modifier, etc. Main focus is the application of CD‐based MIP on sample preparation, detection, and sensing. Additionally, drug delivery with CD‐based MIP is also briefly discussed. Finally, challenges and future prospects of application of CDs in MIP are elaborated.

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Section: Introductionmentioning

confidence: 99%

Recent Advances of Molecularly Imprinted Polymers Based on Cyclodextrin

Zhao

Wang

Zhang

et al. 2021

Macromol. Rapid Commun.

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“…The synergistic effect of molecularly imprinted polymer and dual chiral additives was investigated. Excellent enantioseparation was obtained achieving optical purity up to 90% [154].…”

Section: Imprinted Membranesmentioning

confidence: 98%

“…Lai et al developed a triple recognition chiral extraction process to separate amlodipine (6) based on the combination of molecularly imprinted hollow fiber membrane and cross-flow biphasic recognition extraction [154]. A dismountable hollow fiber module coated with molecularly imprinted polymer was used for the enantiomer separation, and the cross-flow extraction was applied with D-tartaric acid in feed phase and sulfobutyl ether-beta-cyclodextrin in stripping phase.…”

Section: Imprinted Membranesmentioning

confidence: 99%

Chiral Separation in Preparative Scale: A Brief Overview of Membranes as Tools for Enantiomeric Separation

2017

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Given the importance of chirality in the biological response, regulators, industries and researchers require chiral compounds in their enantiomeric pure form. Therefore, the approach to separate enantiomers in preparative scale needs to be fast, easy to operate, low cost and allow obtaining the enantiomers at high level of optical purity. A variety of methodologies to separate enantiomers in preparative scale is described, but most of them are expensive or with restricted applicability. However, the use of membranes have been pointed out as a promising methodology for scale-up enantiomeric separation due to the low energy consumption, continuous operability, variety of materials and supports, simplicity, eco-friendly and the possibility to be integrated into other separation processes. Different types of membranes (solid and liquid) have been developed and may provide applicability in multi-milligram and industrial scales. In this brief overview, the different types and chemical nature of membranes are described, showing their advantages and drawbacks. Recent applications of enantiomeric separations of pharmaceuticals, amines and amino acids were reported.

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“…MIMs may be used on a large scale due to their obvious advantages including ease of preparation, scalability, stability, and low material cost. 216 Interesting reviews about the application of molecularly imprinted membranes can be found in the literature. 98,214,215,[217][218][219][220] The first application of molecularly imprinted membrane was developed by Michael's research group in 1962.…”

Section: Solid Membranes For Chiral Resolutionmentioning

confidence: 99%