Modeling in the Neurosciences 2005
DOI: 10.1201/9780203390979.ch18
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Highly Efficient Propagation of Random Impulse Trains Across Unmyelinated Axonal Branch Points

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Cited by 2 publications
(13 citation statements)
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“…It has been shown previously that this PC scheme (as modified; see Methods section) did not include a supernormal period during recovery in propagated axonal action potentials [27]. The present results revealed that modification of the speed of transitions in the PC scheme's closed loop kinetics influenced the occurrence and magnitude of supernormality.…”
Section: Introductionsupporting
confidence: 49%
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“…It has been shown previously that this PC scheme (as modified; see Methods section) did not include a supernormal period during recovery in propagated axonal action potentials [27]. The present results revealed that modification of the speed of transitions in the PC scheme's closed loop kinetics influenced the occurrence and magnitude of supernormality.…”
Section: Introductionsupporting
confidence: 49%
“…As previously described [27], the kinetic scheme used in the present study differed from Vandenberg and Bezanilla's original scheme [10,77]: (a) the original rate constants between first and second reaction files (i.e., I 4 C 4 and O I) were replaced by rate constants e/f in order to fulfill the required constraint of symmetrical rate constant products within a kinetic loop [34,57,78]; (2) the values of c and f were doubled a to achieve a best fit to single Hodgkin-Huxley (hereafter: HH, [36]) isopotential and propagating action potentials without the inclusion of periaxonal K + accumulation [10,27].…”
Section: Kinetic Scheme Pcmentioning
confidence: 99%
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“…A study of rat paraventricular nucleus and supraoptic nucleus neurons concluded that activity-dependent accumulation of extracellular potassium due to repetitive antidromic axonal firing can reduce axonal excitability leading to slowed conduction and eventual conduction failure (Pittman 1983). In a modeling study of orthodromic propagation through branching myelinated axons, branches with periaxonal K + accumulation experienced prolonged recovery cycles after action potential propagation and did not support shorter interspike intervals that were supported by branches with no periaxonal K + accumulation (Goldfinger 2005). A similar study found that trains of orthodromic impulses were attenuated to a greater degree at 400 Hz with extracellular K + accumulation than without (Zhou and Chiu 2001).…”
Section: Discussionmentioning
confidence: 98%