Highly Efficient Synthesis of Amine-Substituted Diazoacetoacetates from Aldimines and Vinyldiazoacetate Catalysed by MgI₂ Etherate

Abstract

A mild and efficient procedure is described for the synthesis of amine-substituted diazoacetoacetates by the addition of ethyl 3-(tertbutyldimethylsilanoxy)-2-diazobut-3-enoate to aldimines catalysed by MgI 2 etherate (MgI 2 •(OEt 2 ) n ) in MeCN. The reaction produces good to excellent yield at room temperature.