Highly expressed tumoral emmprin and stromal CD73 predict a poor prognosis for external auditory canal carcinoma

Miyazaki, Masaru; Aoki, Mikiko; Okado, Yasuko; Koga, Kaori; Hamasaki, Makoto; Nakagawa, Takashi; Sakata, Toshifumi; Nabeshima, Kazuki

doi:10.1111/cas.14508

Cited by 8 publications

(11 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, high tumoral emmprin and stromal CD73 expression cases were significantly associated with middle cranial fossa invasion and disease recurrence. In vitro analyses confirmed the complex formation between emmprin and CD73, the more abundant production of MMP-2 coming from fibroblasts co-cultured with TBSCC cells than from those cultured alone, and the reduction in MMP-2 production by the transfection of CD73 siRNA into fibroblasts co-cultured with tumor cells [15].…”

Section: Ecm Degradationmentioning

confidence: 66%

“…More recently, Aoki et al [56] reported that extracellular matrix metalloproteinase inducer (emmprin) forms a complex with CD73, a cell surface protein regulating adenosinergic signaling and involved in tumor invasion processes. Subsequently, the same group [15] studied 34 pretreatment biopsy specimens of primary TBSCC, and reported an association between high tumoral emmprin expression and high-grade tumor budding, and between high stromal CD73 expression and high-grade PDCs. Concurrent elevated expression of tumoral emmprin and stromal CD73 was an independent poor prognostic factor for overall survival (OS) in multivariate analysis.…”

Section: Ecm Degradationmentioning

confidence: 99%

See 1 more Smart Citation

Temporal Bone Squamous Cell Carcinoma: Molecular Markers Involved in Carcinogenesis, Behavior, and Prognosis: A Systematic Review

Alessandrini

Astolfi²,

Franz

et al. 2022

IJMS

View full text Add to dashboard Cite

Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a poor prognosis in advanced cases. The dismal outcome of advanced TBSSC cases is largely due to the cancer’s local aggressiveness and the complex anatomy of this region, as well as to persistent pitfalls in diagnosis and treatment. Molecular changes occur in malignancies before any morphological changes become visible, and are responsible for the disease’s clinical behavior. The main purpose of this critical systematic review is to assess the level of knowledge on the molecular markers involved in the biology, behavior, and prognosis of TBSCC. A search (updated to March 2022) was run in PubMed, Scopus, and Web of Science electronic databases without publication date limits for studies investigating molecular markers in cohorts of patients with primary TBSCC. The search terms used were: “temporal bone” OR “external auditory canal” OR “ear”, AND “cancer” OR “carcinoma” OR “malignancy”. We preliminarily decided not to consider series with less than five cases. Twenty-four case series of TBSCC were found in which different analytical techniques had been used to study the role of several biomarkers. In conclusion, only very limited information on the prognostic role of molecular markers in TBSCC are currently available; prospective, multi-institutional, international prognostic studies should be planned to identify the molecular markers involved in the clinical behavior and prognosis of TBSCC. A further, more ambitious goal would be to find targets for therapeutic agents able to improve disease-specific survival in patients with advanced TBSCC.

show abstract

Section: Ecm Degradationmentioning

confidence: 66%

Section: Ecm Degradationmentioning

confidence: 99%

Temporal Bone Squamous Cell Carcinoma: Molecular Markers Involved in Carcinogenesis, Behavior, and Prognosis: A Systematic Review

Alessandrini

Astolfi²,

Franz

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…treatment strategy in this field, accumulation of evidence related to an appropriate staging system and a variety of prognostic factors are desired. Reported prognostic factors include disease stage, surgical margin, 2,3 molecular markers, 6,7 and affected anatomical markers. 8 Recently, inflammation-based factors, represented by the ratio of the absolute inflammatory cell counts in peripheral blood cells (NLR, PLR, and LMR), have been reported as markers for predicting the pretreatment prognosis of various solid tumors, including head and neck SCCs.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, molecular biological features, such as extracellular matrix metalloproteinase inducer (emmprin), CD73, and laminin5-gamma2 are associated with poor survival. 6,7 Furthermore, with regard to the extent of anatomical invasion, the destruction of the middle ear ossicles is also linked to poor survival. 8 The systemic inflammatory response plays a key role in malignant tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma

et al. 2021

Self Cite

View full text Add to dashboard Cite

Objective/Hypothesis: Squamous cell carcinoma (SCC) of the temporal bone is an extremely rare condition. This rarity has led to a delay in the establishment of a standard treatment protocol and adequate staging system. Identification of prognostic markers of this disease from a variety of fields is desirable in the establishment of treatment guidelines for temporal bone SCC. The aim of this study is to assess the prognostic role of inflammation-based prognostic scores in cases of temporal bone SCC.Study Design: Case reries with chart review. Methods: A total of 71 cases of primary malignancy eligible for curative treatment at a single tertiary medical institute were retrospectively analyzed. Univariate and multivariate regression analyzes were used to investigate the association between the inflammation-based scores and 5-year overall survival.Results: Univariate Cox regression analyzes showed that a high neutrophil-to-lymphocyte ratio, high platelet-tolymphocyte ratio, low lymphocyte-to-monocyte ratio, a Glasgow prognostic score of 2, and the systemic inflammation score of 2 were significantly associated with a poor prognosis, as well as a classification of T4 stage, presence of cervical lymph node metastasis, high white blood cell counts, and high C-reactive protein levels. The multivariate analysis showed that a clinical stage of T4 and a systemic inflammation score of 2 were independent prognostic markers.Conclusions: Inflammation-based prognostic markers are associated with the survival of patients with temporal bone SCC, as well as other head and neck SCCs.

show abstract

“…Indeed, high levels of CD73 expression by CAF promote cancer cells proliferation ( 86 ) and are associated with poor prognosis in different cancers like CRC ( 81 ), prostate cancer ( 89 ), Squamous cell carcinoma of the external auditory canal (SCC-EAC) or nonmuscle invasive bladder cancer ( 89 , 90 ).…”

Section: Direct Expression Of Iicps By Cafsmentioning

confidence: 99%

Immune checkpoint inhibitors as mediators for immunosuppression by cancer-associated fibroblasts: A comprehensive review

Eskandari-Malayeri

Rezaei

2022

Front. Immunol.

View full text Add to dashboard Cite

The tumor microenvironment (TME) is a significant contributor to cancer progression containing complex connections between cellular and chemical components and provides a suitable substrate for tumor growth and development. Growing evidence shows targeting tumor cells while ignoring the surrounding TME is not effective enough to overcome the cancer disease. Fibroblasts are essential sentinels of the stroma that due to certain conditions in TME, such as oxidative stress and local hypoxia, become activated, and play the prominent role in the physical support of tumor cells and the enhancement of tumorigenesis. Activated fibroblasts in TME, defined as cancer-associated fibroblasts (CAFs), play a crucial role in regulating the biological behavior of tumors, such as tumor metastasis and drug resistance. CAFs are highly heterogeneous populations that have different origins and, in addition to their role in supporting stromal cells, have multiple immunosuppressive functions via a membrane and secretory patterns. The secretion of different cytokines/chemokines, interactions that mediate the recruitment of regulatory immune cells and the reprogramming of an immunosuppressive function in immature myeloid cells are just a few examples of how CAFs contribute to the immune escape of tumors through various direct and indirect mechanisms on specific immune cell populations. Moreover, CAFs directly abolish the role of cytotoxic lymphocytes. The activation and overexpression of inhibitory immune checkpoints (iICPs) or their ligands in TME compartments are one of the main regulatory mechanisms that inactivate tumor-infiltrating lymphocytes in cancer lesions. CAFs are also essential players in the induction or expression of iICPs and the suppression of immune response in TME. Based on available studies, CAF subsets could modulate immune cell function in TME through iICPs in two ways; direct expression of iICPs by activated CAFs and indirect induction by production soluble and then upregulation of iICPs in TME. With a focus on CAFs’ direct and indirect roles in the induction of iICPs in TME as well as their use in immunotherapy and diagnostics, we present the evolving understanding of the immunosuppressive mechanism of CAFs in TME in this review. Understanding the complete picture of CAFs will help develop new strategies to improve precision cancer therapy.

show abstract

Highly expressed tumoral emmprin and stromal CD73 predict a poor prognosis for external auditory canal carcinoma

Cited by 8 publications

References 43 publications

Temporal Bone Squamous Cell Carcinoma: Molecular Markers Involved in Carcinogenesis, Behavior, and Prognosis: A Systematic Review

Temporal Bone Squamous Cell Carcinoma: Molecular Markers Involved in Carcinogenesis, Behavior, and Prognosis: A Systematic Review

Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma

Immune checkpoint inhibitors as mediators for immunosuppression by cancer-associated fibroblasts: A comprehensive review

Contact Info

Product

Resources

About