Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma

Jumai, Kawuli; Zhang, Tangjuan; Qiao, Bingzhang; Ainiwaer, Julaiti; Zhang, Haiping; Hou, Zhichao; Awut, Idris; Niyaz, Madinyat; Zhang, Liwei; Sheyhidin, Ilyar

doi:10.1155/2022/2555647

Cited by 6 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since its invention, gene microarray has been utilized extensively in scientific research, the biopharmaceutical industry, and medical diagnostics. By using gene microarrays technology, Zhumai et al discovered that scavenger receptor class A member 5 (SCARA5) was a downstream driver of thrombospondin type 1 domain‐containing 7A (THSD7A) in esophageal squamous cell carcinoma (ESCC), and SCARA5 could promote the proliferation and migration of ESCC cells 22 . Cai et al used protein and gene microarrays to compare wild‐type (WT) and drug‐resistant (DR) Pseudomonas aeruginosa.…”

Section: Introductionmentioning

confidence: 99%

“…By using gene microarrays technology, Zhumai et al discovered that scavenger receptor class A member 5 (SCARA5) was a downstream driver of thrombospondin type 1 domain‐containing 7A (THSD7A) in esophageal squamous cell carcinoma (ESCC), and SCARA5 could promote the proliferation and migration of ESCC cells. 22 Cai et al used protein and gene microarrays to compare wild‐type (WT) and drug‐resistant (DR) Pseudomonas aeruginosa. The results showed that there were 679 mutation sites in the DR Group, and the drug resistance rate of cefoperazone sodium/sulbactam sodium remained high from 2013 to 2015.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma

Huang

Zhou

Yang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Lung adenocarcinoma (LUAD) is a highly malignant tumor with a very low five‐year survival rate. In this study, we aimed to identify differentially expressed long‐chain non‐coding RNA (lncRNAs) and mRNAs from benign and malignant pleural effusion exosomes. Methods We used gene microassay and quantitative real‐time reverse transcription polymerase chain reaction (RT‐qPCR) to detect and verify differentially expressed mRNAs and lncRNAs in benign and malignant pleural effusion exosomes. Gene Ontology (GO) functional significance and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway significance enrichment analyses were performed to identify the difference in biological processes and functions between different mRNAs. We selected the lncRNA ZBED5‐AS1 with an upregulated differential fold of 3.003 and conducted a preliminary study on its cellular function. Results Gene microassay results revealed that 177 differentially expressed lncRNAs were upregulated, and 215 were downregulated. The top 10 upregulated were FMN1, AL118505.1, LINC00452, AL109811.2, CATG00000040683.1, AC137932.1, AC008619.1, AL450344.1, AC092718.6, and ZBED5‐AS1. The top 10 downregulated were TEX41, G067726, JAZF1‐AS1, AC027328.1, AL445645.1, AL022345.4, AC008572.1, AC123777.1, AC093714.1, and PHKG1. For the mRNAs, 79 were upregulated, and 123 were notably downregulated. GO analysis revealed that the upregulated differential mRNAs were mainly involved in “cellular response to acidic pH” (biological processes), “endoplasmic reticulum part” (cellular components), and “at DNA binding, cyclase activity” (molecular functions). KEGG pathways were found to be related to V. cholerae infection, Parkinson's disease, and cell adhesion molecules. RT‐qPCR showed that ZBED5‐AS1 was highly expressed in LUAD tissues, cells, and benign and malignant pleural fluid exosomes. Overexpression of ZBED5‐AS1 could significantly promote the proliferation, migration, invasion, and colony formation of LUAD cells, and knockdown had the opposite consequence. Conclusion The pleural effusion exosomes from patients with LUAD include several improperly expressed genes, and lncRNA‐ZBED5‐AS1 is a new biomarker that aids in our understanding of the occurrence and progression of LUAD.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma

Huang

Zhou

Yang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…They also stated that SCARA5 promotes the proliferation and migration of ESCC cells and that SCARA5 is expressed differently between ESCC and normal esophageal tissue. However, they did not find any significant association between SCARA5 expression and clinicopathological parameters or prognosis [ 31 ]. There is also evidence that SCARA 5 directly interacts with FAK.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Jumai et al reported scavenger receptor class A member 5 (SCARA5) to be the downstream gene of THSD7A in esophageal squamous cell carcinoma (ESCC) [ 31 ]. Not much is known about SCARA5.…”

Section: Introductionmentioning

confidence: 99%

SCARA5 Is Overexpressed in Prostate Cancer and Linked to Poor Prognosis

et al. 2023

View full text Add to dashboard Cite

Prostate cancer is one of the most common malignancies worldwide, showing a wide range of clinical behaviors. Therefore, several treatment options arise out of the diagnosis “prostate cancer”. For this reason, it is desirable to find novel prognostic and predictive markers. In former studies, we showed that THSD7A expression is associated with unfavorable prognostic parameters in prostate cancer and is linked to a high expression of focal adhesion kinase (FAK). Recently, scavenger receptor class A member 5 (SCARA5) was reported to be the downstream gene of THSD7A in esophageal squamous cell carcinoma. SCARA5 is believed to play an important role in the development and progression of several different tumor types. Most studies describe SCARA5 as a tumor suppressor. There is also evidence that SCARA 5 interacts with FAK. To examine the role of SCARA5 as a potential biomarker in prostate cancer, a total of 461 prostate cancers were analyzed via immunohistochemistry using tissue microarrays. Furthermore, we compared the expression level of SCARA5 with our previously collected data on THSD7A and FAK. High SCARA5 expression was associated with advanced tumor stage (p < 0.001), positive nodal status (p < 0.001) and high Gleason-score (p < 0.001). At least, strongly SCARA5-positive cancers were associated with THSD7A-positivity. There was no significant association between SCARA5 expression level and FAK expression level. To our knowledge, we are the first to investigate the role of SCARA5 in prostate cancer and we demonstrated that SCARA5 might be a potential biomarker in prostate cancer.

show abstract

“…However, its effects on ESCC proliferation and migration are contradictory and need to be confirmed by further studies [67]…”

Section: Iron Metabolism In Escc With Ferroptosismentioning

confidence: 98%

The Mechanism and Research Progress of Ferroptosis in Esophageal Squamous Cell Carcinoma

Gong,

Tan

2023

JBM

View full text Add to dashboard Cite

Esophageal squamous cell carcinoma (ESCC), as the main histological type of esophageal cancer (EC), has the characteristics of high malignant degree, high mortality and tendency to lymph node metastasis. Despite the combination of surgery and chemoradiotherapy, ECSS has a poor prognosis. Ferroptosis is a newly discovered iron-dependent programmed cell death pattern characterized by the accumulation of lipid peroxidation and characteristic morphological changes of mitochondria. It regulates the growth and invasion of cancer cells in various tumors such as gastric cancer and pancreatic cancer. In this article, we mainly introduce the ferroptosis regulatory mechanism in ESCC, hoping to provide a new direction and ideas for the treatment of ECSS.

show abstract

Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma

Cited by 6 publications

References 37 publications

Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma

Construction and analysis of expression profile of exosomal lncRNAs in pleural effusion in lung adenocarcinoma

SCARA5 Is Overexpressed in Prostate Cancer and Linked to Poor Prognosis

The Mechanism and Research Progress of Ferroptosis in Esophageal Squamous Cell Carcinoma

Contact Info

Product

Resources

About