Highly hemocompatible zwitterionic micelles stabilized by reversible cross-linkage for anti-cancer drug delivery

Lin, Weifeng; He, Yueying; Zhang, Juan; Wang, Longgang; Wang, Zhen; Ji, Fangqin; Chen, Shengfu

doi:10.1016/j.colsurfb.2013.12.020

Cited by 32 publications

(22 citation statements)

References 42 publications

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“…Additionally, the nano-micelles exposed to fibrinogen or 50 % FBS did not show any significant difference in the particle size confirming them to stable under tested conditions (Figure 4a). Similar observations were noted by earlier investigators 47 . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 15 seen with the targeted nano-micelles.…”

Section: Anticancer Activity Of Targeted and Non-targeted Nano-micellsupporting

confidence: 88%

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

et al. 2015

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Cancer stem-like cells (CSLCs) play a pivotal role in acquiring multidrug resistant (MDR) phenotypes. It has been established that pancreatic cancers overexpressing CD44 receptors (a target of hyaluronic acid; HA) is one of the major contributors for causing MDR. Therefore, targeted killing of CD44 expressing tumor cells using HA based active targeting strategies may be beneficial for eradicating MDR-pancreatic cancers. Here, we report the synthesis of a new HA conjugate of copoly(styrene maleic acid) (HA-SMA) that could be engineered to form nanomicelles with a potent anticancer agent, 3,4-difluorobenzylidene curcumin (CDF). The anticancer activity of CDF loaded nanomicelles against MiaPaCa-2 and AsPC-1 human pancreatic cancer cells revealed dose-dependent cell killing. Results of cellular internalization further confirmed better uptake of HA engineered nanomicelles in triple-marker positive (CD44+/CD133+/EpCAM+) pancreatic CSLCs compared with triple-marker negative (CD44-/CD133-/EpCAM-) counterparts. More importantly, HA-SMA-CDF exhibited superior anticancer response toward CD44+ pancreatic CSLCs. Results further confirmed that triple-marker positive cells treated with HA-SMA-CDF caused significant reduction in CD44 expression and marked inhibition of NF-κB that in-turn can mitigate their proliferative and invasive behavior. Conclusively, these results suggest that the newly developed CD44 targeted nanomicelles may have great implications in treating pancreatic cancers including the more aggressive pancreatic CSLCs.

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Section: Anticancer Activity Of Targeted and Non-targeted Nano-micellsupporting

confidence: 88%

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

et al. 2015

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“…After intravenous injection in human hypopharyngeal carcinoma-bearing mouse models, the PSBMA nanogel showed excellent properties including high tumor accumulation, excellent biodegradation, long circulation, and sufficient drug release. And to enhance the stability of zwitterionic amphiphilic copolymers, Chen’s team synthesized a random copolymer P(CMBA- co -MAEL) by using zwitterionic carboxybetaine methacrylate as hydrophilic part and disulfide containing 2-(methacryloyloxy) ethyl lipoate as hydrophobic segment [111] . They first used Tris(2-carboxyethyl) phosphine to reduce the disulfides from MAEL, then stirred the mixture to form shell-cross-linked micelles via O 2 -mediated oxidization.…”

Section: Applications Of Zwitterionic Materials In Drug Delivery Systmentioning

confidence: 99%

Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

Zhou

Zhu

Wang

et al. 2020

Computational and Structural Biotechnology Journal

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“…We have thus investigated the stability of the developed nano-micelles against fibrinogen (1 mg/mL in PBS 7.4) or 50% FBS (diluted with 0.1 N PBS) using DLS. For this purpose, the nano-micelles (1 mg/mL) suspended in PBS were mixed with fibrinogen (1 mg/mL) dissolved in PBS or 50% FBS at 37 • C. After predetermined time periods (up to 4 days) samples were withdrawn and the size of the nano-micelles was analyzed by DLS measurements (n = 3) [34].…”

Section: Hemocompatibility and Stability Of Nano-micelles Under Storamentioning

confidence: 99%

Parenterally administrable nano-micelles of 3,4-difluorobenzylidene curcumin for treating pancreatic cancer

Kesharwani

Banerjee

Padhyé

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Highly hemocompatible zwitterionic micelles stabilized by reversible cross-linkage for anti-cancer drug delivery

Cited by 32 publications

References 42 publications

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

Parenterally administrable nano-micelles of 3,4-difluorobenzylidene curcumin for treating pancreatic cancer

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