Highly oxygenated isoprenylated cyclohexanoids from the fungus Parastagonospora nodorum SN15

Phytotoxic Secondary Metabolites from Fungi

“…Stagonosporyne G (545) was an oxygenated acetylenic cyclohexanoid isolated from the Parastagonospora nodorum SN15, the pathogen of wheat. This compound displayed a significant phytotoxic activity by killing Arabidopsis thaliana seedlings [339].…”

Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum

“…Despite a number of previous studies on P. nodorum secondary metabolites [28][29][30] and more recent studies, including metabolite profiling of a sch1 mutant, 31 the use of epigenetic modifiers, 32 and growth on rice substrates, 33 which resulted in new compounds discovered from P. nodorum, no cytochalasan-like compound has been reported. 34 Our previous work on elsinochrome C 24 and stemphyloxin II 26 (Table S3), isolated from a marine sediment-derived fungus Westerdykella dispersa.…”

“…Despite a number of previous studies on P. nodorum secondary metabolites − and more recent studies, including metabolite profiling of a sch1 mutant, the use of epigenetic modifiers, and growth on rice substrates, which resulted in new compounds discovered from P. nodorum , no cytochalasan-like compound has been reported . Our previous work on elsinochrome C and stemphyloxin II has shown that overexpression of pathway-specific transcription factors can be an effective means to increase the targeted metabolite production and link the targeted gene cluster to its metabolite product(s) in P. nodorum .…”

Chemical diversity, medicinal potentialities, biosynthesis, and pharmacokinetics of anthraquinones and their congeners derived from marine fungi: a comprehensive update

“…28 Whereas Greco et al in their recent review critically described the marinederived anthraquinones which showed anti-tumor activity as well as their mutagenic and genotoxic potentialities. 29 Herein and as a part of our continuous program on pharmacologically active fungal natural products, 4,30,31 we are presenting an extensive coverage over the period 2000-2020 for 208 anthraquinones and their derivatives, extensively reported from different marinederived fungal genera such as Nigrospora, Aspergillus, Penicillium, Stemphylium, Alternaria, Eurotium, Trichoderma, Halorosellinia, and Fusarium. In addition, we reported here their different biological activities, drug-likeliness and pharmacokinetics properties wherever applicable, in addition to a general overview of their proposed biogenesis pathway.…”