Highly sensitive and selective detection of glutathione using ultrasonic aided synthesis of graphene quantum dots embedded over amine-functionalized silica nanoparticles

Kaimal, Reshma; Vinoth, Victor; Salunke, Amol Shrikrishna; Hector, Valdes; Mangalaraja, Ramalinga Viswanathan; Aljafari, Belqasem; Anandan, Sambandam

doi:10.1016/j.ultsonch.2021.105868

Cited by 31 publications

(20 citation statements)

References 53 publications

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“…These CDs are useful fluorescent inks that can be applied in the anticounterfeit field, monitoring trace species, and applications in food chemistry. Graphene quantum dots (GQDs) prepared by the ultrasonic process were incorporated on the surface of amine-functionalized Si nanoparticles (SiNPs) through the amide linkage to make the GQDs-SiNPs nanocomposite [ 48 ]. The GQDs-SiNPs/GC electrode was proved to have high activity for glutathione sensing.…”

Section: Preparation and Modification Of Cdsmentioning

confidence: 99%

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Pundi

Chang

2022

Polymers

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Although there is significant progress in the research of carbon dots (CDs), some challenges such as difficulty in large-scale synthesis, complicated purification, low quantum yield, ambiguity in structure-property correlation, electronic structures, and photophysics are still major obstacles that hinder the commercial use of CDs. Recent advances in synthesis, modification, characterization, and applications of CDs are summarized in this review. We illustrate some examples to correlate process parameters, structures, compositions, properties, and performances of CDs-based materials. The advances in the synthesis approach, purification methods, and modification/doping methods for the synthesis of CDs are also presented. Moreover, some examples of the kilogram-scale fabrication of CDs are given. The properties and performance of CDs can be tuned by some synthesis parameters, such as the incubation time and precursor ratio, the laser pulse width, and the average molar mass of the polymeric precursor. Surface passivation also has a significant influence on the particle sizes of CDs. Moreover, some factors affect the properties and performance of CDs, such as the polarity-sensitive fluorescence effect and concentration-dependent multicolor luminescence, together with the size and surface states of CDs. The synchrotron near-edge X-ray absorption fine structure (NEXAFS) test has been proved to be a useful tool to explore the correlation among structural features, photophysics, and emission performance of CDs. Recent advances of CDs in bioimaging, sensing, therapy, energy, fertilizer, separation, security authentication, food packing, flame retardant, and co-catalyst for environmental remediation applications were reviewed in this article. Furthermore, the roles of CDs, doped CDs, and their composites in these applications were also demonstrated.

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Section: Preparation and Modification Of Cdsmentioning

confidence: 99%

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Pundi

Chang

2022

Polymers

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“…Due to their specificity in spatial dimensions, nanomaterials possess properties that are different from those of macroscopic materials, such as surface effects and small size effects. 42 These properties not only endow nanomaterials with high catalytic activity to enhance the bioavailability of drugs but also endow nanomaterials with good protection and penetration, which can protect drugs from enzymatic degradation and facilitate drug absorption, thus enabling targeted delivery to tumor tissues and improved drug delivery efficiency. Nanomaterials as delivery carriers can increase drug loading, prolong their circulation time, improve their bioavailability and achieve drug enrichment in specific organs or tissues due to their unique physicochemical properties, pharmacokinetic characteristics and modifiable biodistribution.…”

Section: Nanomaterialsmentioning

confidence: 99%

“…In addition, liposomes modified with sugar residues, receptor ligands, antibodies, hormones and other ligands can bind specifically to tumor cell target proteins and enter the cells through receptor-mediated endocytosis, accelerating the application of nanomedicine delivery to tumors. [41][42][43][44]…”

Section: Liposomesmentioning

confidence: 99%

Natural Products-Based Nanoformulations: A New Approach Targeting CSCs to Cancer Therapy

Liao¹,

Li²,

Wang

et al. 2022

IJN

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Cancer stem cells (CSCs) lead to the occurrence and progression of cancer due to their strong tumorigenic, self-renewal, and multidirectional differentiation abilities. Existing cancer treatment methods cannot effectively kill or inhibit CSCs but instead enrich them and produce stronger proliferation, invasion, and metastasis capabilities, resulting in cancer recurrence and treatment resistance, which has become a difficult problem in clinical treatment. Therefore, targeting CSCs may be the most promising approach for comprehensive cancer therapy in the future. A variety of natural products (NP) have significant antitumor effects and have been identified to target and inhibit CSCs. However, pharmacokinetic defects and off-target effects have greatly hindered their clinical translation. NP-based nanoformulations (NPNs) have tremendous potential to overcome the disadvantages of NP against CSCs through site-specific delivery and by improving their pharmacokinetic parameters. In this review, we summarize the recent progress of NPNs targeting CSCs in cancer therapy, looking forward to transforming preclinical research results into clinical applications and bringing new prospects for cancer treatment.

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“…However, it is difficult to detect the concentration of glutathione due to the instability of glutathione in solution and its tendency to be oxidized to form disulfides. Thus far, scientists have proposed several different analytical methods for glutathione analysis, such as ultraviolet spectrophotometry [ 6 ], fluorescence spectrophotometry [ 7 ], mass spectrometry [ 8 ], high-performance liquid chromatography [ 9 ], flow injection analysis [ 10 ], and enzymatic [ 11 ] and electrochemical methods [ 12 , 13 , 14 , 15 , 16 ]. However, most of the aforesaid methods have some limitations, such as the necessity for complex and expensive instruments, the demand for skill-based operation, and time-consuming nature.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive and Selective Detection of Glutathione by Ammonium Carbamate–Gold Platinum Nanoparticles-Based Electrochemical Sensor

Wang

Chen

Zhou

et al. 2022

Life

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Determining the concentration of glutathione is crucial for developing workable medical diagnostic strategies. In this paper, we developed an electrochemical sensor by electrodepositing amino-based reactive groups and gold–platinum nanomaterials on the surface of glassy carbon electrode successively. The sensor was characterized by cyclic voltammetry (CV), field emission scanning electron microscope (FESEM), energy dispersive X-ray spectroscopy (EDX), and electrochemical impedance spectra (EIS). Results showed that Au@Pt nanoparticles with the size of 20–40 nm were presented on the surface of electrode. The sensor exhibits excellent electrocatalytic oxidation towards glutathione. Based on this, we devised an electrochemical biosensor for rapid and sensitive detection of glutathione. After optimizing experimental and operational conditions, a linear response for the concentration of GSH, in the range of 0.1–11 μmol/L, with low detection and quantification limits of 0.051 μM (S/N = 3), were obtained. The sensor also exhibits superior selectivity, reproducibility, low cost, as well as simple preparation and can be applied in human serum sample detection.

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Highly sensitive and selective detection of glutathione using ultrasonic aided synthesis of graphene quantum dots embedded over amine-functionalized silica nanoparticles

Abstract: Graphical abstract

Cited by 31 publications

References 53 publications

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Natural Products-Based Nanoformulations: A New Approach Targeting CSCs to Cancer Therapy

Ultrasensitive and Selective Detection of Glutathione by Ammonium Carbamate–Gold Platinum Nanoparticles-Based Electrochemical Sensor

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