Highly Sensitive and Selective Electrochemical Sensor Based on Polyglycine Modified Glassy Carbon Electrode for Simultaneous Determination of Amlodipine and Ramipril from Biological Samples

Abstract

In this study, the electrochemical behavior of the antihypertensive drugs amlodipine (AML) and ramipril (RAM) was investigated on polyglycine modified glassy carbon electrode (Poly(Gly)/GCE) as simultaneously. A simple and highly sensitive differential pulse adsorptive stripping voltammetric (DPAdSV) technique was developed for the simultaneous electrochemical determination of AML and RAM in 0.1 M H 2 SO 4 solution (pH 1.0). The oxidation process of both analytes was found to be irreversible and exhibited mixed diffusion under adsorption-controlled process. The oxidation mechanism of drugs was proposed using the obtained data and discussed. The Poly(Gly)/GCE showed an enhancement effects on the oxidation current of AML and RAM with the significant peak potential differences of 0.52 V by AdSDPV technique. At the optimum conditions, the proposed method exhibited linear responses in concentration ranges 0.5-25 μM for AML and RAM with the detection limits of 0.08 and 0.130 μM, respectively. Finally, the proposed sensor was successfully applied for the sensitive detection and simultaneous determination of AML and RAM in human serum and human urine samples.

The Selective Electrochemical Sensing of Naringin Using Electropolymerized Ellagic Acid Film

“…Electrochemical sensors on the basis of modified electrodes with electrochemically formed polymeric films are actively developed area of modern electroanalysis. [1][2][3][4][5] Among a wide range of substances capable to polymerization, phenolic compounds are of interest in particular natural phenolic acids (gallic, syringic, vanillic, p-coumaric, caffeic and ferulic). Phenolic acids containing pyrocatechol fragment in their structure are most often applied as monomers due to formation of a redox pare o-quinone/pyrocatechol providing electrocatalytic effect towards oxidation of different analytes.…”

Nanosensors in the detection of antihypertension drugs, a golden step for medication adherence monitoring

“…A highly sensitive and selective biosensor based on polyglycine-modified GCE was further developed for the real-time detection of AML and ramipril in human serum and human urine samples. The created method was highly sensitive, rapid and economical for drug detection from biological samples without the need for laborious sample extraction, filtration, evaporation and pretreatment steps [ 47 ]. Sodium dodecylbenzenesulfonate–based silver nanoparticles (SDBS-AgNPs) and their potent application as antimicrobial agent antibiofilm, and trace level determination of AML [ 48 ].…”