Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@Au@SiO2 for serotonin determination

Amatatongchai, Maliwan; Sitanurak, Jirayu; Sroysee, Wongduan; Sodanat, Suriyaphon; Chairam, Sanoe; Jarujamrus, Purim; Nacapricha, Duangjai; Lieberzeit, Peter A.

doi:10.1016/j.aca.2019.05.047

Cited by 99 publications

(43 citation statements)

References 42 publications

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“…When greater precision and control are required, a previous optimization process has to be performed for the precise adjustment of ink droplet volume, ejection speed, and spacing. In this context, a PAD for serotonin determination was reported [27]. Two 8-mm diameter circled hydrophilic areas were defined on Whatman filter paper grade No.…”

Section: Paper-based Analytical Devices (Pads) With Integrated Electrmentioning

confidence: 99%

Electrochemical Paper-Based Biosensor Devices for Rapid Detection of Biomarkers

Gutiérrez-Capitán

Baldi

Fernández‐Sánchez

2020

Sensors

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In healthcare, new diagnostic tools that help in the diagnosis, prognosis, and monitoring of diseases rapidly and accurately are in high demand. For in-situ measurement of disease or infection biomarkers, point-of-care devices provide a dramatic speed advantage over conventional techniques, thus aiding clinicians in decision-making. During the last decade, paper-based analytical devices, combining paper substrates and electrochemical detection components, have emerged as important point-of-need diagnostic tools. This review highlights significant works on this topic over the last five years, from 2015 to 2019. The most relevant articles published in 2018 and 2019 are examined in detail, focusing on device fabrication techniques and materials applied to the production of paper fluidic and electrochemical cell architectures as well as on the final device assembly. Two main approaches were identified, that are, on one hand, those ones where the fabrication of the electrochemical cell is done on the paper substrate, where the fluidic structures are also defined, and, on the other hand, the fabrication of those ones where the electrochemical cell and liquid-driving paper component are defined on different substrates and then heterogeneously assembled. The main limitations of the current technologies are outlined and an outlook on the current technology status and future prospects is given.

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Section: Paper-based Analytical Devices (Pads) With Integrated Electrmentioning

confidence: 99%

Electrochemical Paper-Based Biosensor Devices for Rapid Detection of Biomarkers

Gutiérrez-Capitán

Baldi

Fernández‐Sánchez

2020

Sensors

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“…In this context, the special features of paper as support material for the preparation of diagnostic devices, together with those of screen-printed platforms, represents an important advance for easy self-testing and point-of-care (POC) assessment. Table 2 summarizes the analytical characteristics and the main properties of some recent and representative methods applied to analytes of clinical interest in biological samples [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Some selected examples are discussed below.…”

Section: Screen-printed Paper Electrochemical (Bio)sensorsmentioning

confidence: 99%

Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing

2020

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Screen-printing technology has revolutionized many fields, including that of electrochemical biosensing. Due to their current relevance, this review, unlike other papers, discusses the relevant aspects of electrochemical biosensors manufactured using this technology in connection to both paper substrates and wearable formats. The main trends, advances, and opportunities provided by these types of devices, with particular attention to the environmental and biomedical fields, are addressed along with illustrative fundamentals and applications of selected representative approaches from the recent literature. The main challenges and future directions to tackle in this research area are also pointed out.

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“…The authors of a recent investigation report efforts to enhance electrical conductivity of MIP binding in an ECM serotonin biosensor (171). Nanocomposites prepared in this study were of the core-shell variety (Fig.…”

Section: Silica Nanomaterials (Snms)mentioning

confidence: 99%

“…However, when MIPs are applied to ECM transduction strategies a fundamental handicap becomes apparent. The insulating nature of most functional monomers causes MIPs to inhibit ECM signal generation (167,171,194,195), thus sacrificing sensitivity. Molecularly imprinted electrodes have been shown to suffer from the adhesion of large, dynamic molecules, like enzymes.…”

Section: Electrochemical (Ecm) Transductionmentioning

confidence: 99%

Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction

Denmark

Mohapatra

2020

The EuroBiotech Journal

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Significant healthcare disparities resulting from personal wealth, circumstances of birth, education level, and more are internationally prevalent. As such, advances in biomedical science overwhelmingly benefit a minority of the global population. Point-of-Care Testing (POCT) can contribute to societal equilibrium by making medical diagnostics affordable, convenient, and fast. Unfortunately, conventional POCT appears stagnant in terms of achieving significant advances. This is attributed to the high cost and instability associated with conventional biorecognition: primarily antibodies, but nucleic acids, cells, enzymes, and aptamers have also been used. Instead, state-of-the-art biosensor researchers are increasingly leveraging molecularly imprinted polymers (MIPs) for their high selectivity, excellent stability, and amenability to a variety of physical and chemical manipulations. Besides the elimination of conventional bioreceptors, the incorporation of nanomaterials has further improved the sensitivity of biosensors. Herein, modern nanobiosensors employing MIPs for selectivity and nanomaterials for improved transduction are systematically reviewed. First, a brief synopsis of fabrication and wide-spread challenges with selectivity demonstration are presented. Afterward, the discussion turns to an analysis of relevant case studies published in the last five years. The analysis is given through two lenses: MIP-based biosensors employing specific nanomaterials and those adopting particular transduction strategies. Finally, conclusions are presented along with a look to the future through recommendations for advancing the field. It is hoped that this work will accelerate successful efforts in the field, orient new researchers, and contribute to equitable health care for all.

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Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@Au@SiO2 for serotonin determination

Cited by 99 publications

References 42 publications

Electrochemical Paper-Based Biosensor Devices for Rapid Detection of Biomarkers

Electrochemical Paper-Based Biosensor Devices for Rapid Detection of Biomarkers

Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing

Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction

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