Highly Sensitive Assay for Acetylcholinesterase Activity and Inhibition Based on a Specifically Reactive Photonic Nanostructure

Tian, Tian; Li, Xuesong; Cui, Jiecheng; Li, Jian; Lan, Yue; Wang, Chen; Zhang, Meng; Wang, Hui; Li, Guangtao

doi:10.1021/am504065v

Cited by 48 publications

(16 citation statements)

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“…279 This level is comparable to other existing highly sensitive methods such as those based on gold nanoparticles, 314 but the CBPM indicator is more reliable, particularly in complex solutions. 279 An example of a pH-responsive inverse opal hydrogel sensor with high selectivity and sensitivity to mercury ions is shown in Figure 20. 278 An additional method to introduce binding specificity to hydrogel materials is molecular imprinting.…”

Section: Factors Influencing Sensing Applicationsmentioning

confidence: 54%

A colloidoscope of colloid-based porous materials and their uses

et al. 2016

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Nature evolved a variety of hierarchical structures that produce sophisticated functions. Inspired by these natural materials, colloidal self-assembly provides a convenient way to produce structures from simple building blocks with a variety of complex functions beyond those found in nature. In particular, colloid-based porous materials (CBPM) can be made from a wide variety of materials. The internal structure of CBPM also has several key attributes, namely porosity on a sub-micrometer length scale, interconnectivity of these pores, and a controllable degree of order. The combination of structure and composition allow CBPM to attain properties important for modern applications such as photonic inks, colorimetric sensors, self-cleaning surfaces, water purification systems, or batteries. This review summarizes recent developments in the field of CBPM, including principles for their design, fabrication, and applications, with a particular focus on structural features and materials' properties that enable these applications. We begin with a short introduction to the wide variety of patterns that can be generated by colloidal self-assembly and templating processes. We then discuss different applications of such structures, focusing on optics, wetting, sensing, catalysis, and electrodes. Different fields of applications require different properties, yet the modularity of the assembly process of CBPM provides a high degree of tunability and tailorability in composition and structure. We examine the significance of properties such as structure, composition, and degree of order on the materials' functions and use, as well as trends in and future directions for the development of CBPM.

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Section: Factors Influencing Sensing Applicationsmentioning

confidence: 54%

A colloidoscope of colloid-based porous materials and their uses

et al. 2016

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“…Enzymatic inhibition is considered as the key point in clinical applications and drug therapy. Indeed, several drugs such as neostigmine, donepezil, allopurinol, methimazole and moclobemide induce the inhibition of target enzymes involved in various diseases [ 42 , 43 , 44 ]. Accordingly, sensitive biosensors based on enzyme inhibition are highly required to monitor these drugs.…”

Section: Diagnosis Of Inhibition Typementioning

confidence: 99%

Recent Advances in Electrochemical Biosensors Based on Enzyme Inhibition for Clinical and Pharmaceutical Applications

Harrad

Bourais

Mohammadi

et al. 2018

Sensors

114

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A large number of enzyme inhibitors are used as drugs to treat several diseases such as gout, diabetes, AIDS, depression, Parkinson’s and Alzheimer’s diseases. Electrochemical biosensors based on enzyme inhibition are useful devices for an easy, fast and environment friendly monitoring of inhibitors like drugs. In the last decades, electrochemical biosensors have shown great potentials in the detection of different drugs like neostigmine, ketoconazole, donepezil, allopurinol and many others. They attracted increasing attention due to the advantage of being high sensitive and accurate analytical tools, able to reach low detection limits and the possibility to be performed on real samples. This review will spotlight the research conducted in the past 10 years (2007–2017) on inhibition based enzymatic electrochemical biosensors for the analysis of different drugs. New assays based on novel bio-devices will be debated. Moreover, the exploration of the recent graphical approach in diagnosis of reversible and irreversible inhibition mechanism will be discussed. The accurate and the fast diagnosis of inhibition type will help researchers in further drug design improvements and the identification of new molecules that will serve as new enzyme targets.

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“…Acetylcholinesterase (AChE), a crucial enzyme for the treatment of Alzheimer's diseases (AD), can catalyze the hydrolysis of acetylcholine (ACh) into choline and acetic acid, 1,2 leading to the termination of neurotransmission such as ACh at the cholinergic synapse in the neurological system. Meanwhile, a low level of ACh in the brain assumes responsibility for the symptom of AD, 3 which affects approximately 44 million people worldwide.…”

Section: Introductionmentioning

confidence: 99%