Highly Sensitive Biomolecule Detection on a Quartz Crystal Microbalance Using Gold Nanoparticles as Signal Amplification Probes

Kim, Nam Hyun; Baek, Taek Jin; Park, Hyun Gyu; Seong, Gi Hun

doi:10.2116/analsci.23.177

Cited by 33 publications

(18 citation statements)

References 27 publications

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“…1047–1052 For example, detection of streptavidin on a QCM has been achieved using AuNPs as a signal amplifier. 1053 The experimental set up involves the immobilization of biotinylated BSA on the gold surface of the QCM electrode. Addition of streptavidin generates a small frequency change that is amplified by incubation with biotin functionalized AuNP providing a detection limit of 1 ng/mL.…”

Section: Aunps In Quartz Crystal Microbalance-based Sensingmentioning

confidence: 99%

Gold Nanoparticles in Chemical and Biological Sensing

et al. 2012

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Section: Aunps In Quartz Crystal Microbalance-based Sensingmentioning

confidence: 99%

Gold Nanoparticles in Chemical and Biological Sensing

et al. 2012

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“…Obviously, AuNPs have a significant signal amplification effect in QCM biosensors due to their heavier masses than biomolecules. Owing to their high density, AuNPs have potential as labels to increase the mass change on the quartz surface [48,49,50]. Jiang et al used AuNPs of 50 nm as the mass enhancer to amplify the frequency signal of QCM, which reached a low detection limit of 10 −14 M for target DNA [51].…”

Section: Piezoelectric Biosensorsmentioning

confidence: 99%

Applications of Gold Nanoparticles in Non-Optical Biosensors

et al. 2018

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Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.

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“…A highly sensitive biomolecule sensor using gold nanoparticles as signal amplification probes employed a streptavidin‐biotin interaction as a model system and showed good linearity over a wide range from 1 ng/mL to 10 ug/mL for the quantitative streptavidin target molecule analysis (Kim et al ., 2007c). The adsorption characteristics of three proteins (bovine serum albumin, myoglobin and cytochrome c) onto self‐assembled monolayers of mercaptoundecanoic acid on both gold nanoparticles and gold surfaces were described (Kaufman et al , 2007).…”

Section: Protein Interactionsmentioning

confidence: 99%

A survey of the 2006–2009 quartz crystal microbalance biosensor literature

Becker

Cooper

2011

J of Molecular Recognition

163

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Since the publication of the original review of piezoelectric acoustic sensors in this series there has been a consistent, gradual expansion in the number of published papers using 'quartz crystal microbalances' (QCM). Between 2001 and 2009, the number of QCM publications per annum has increased from 49 to 273, with a two-fold increase in papers per annum between 2004 and 2008. Within the field, comparing the time covered by the current to the previous review, there are trends towards increasing use of QCM in the study of protein adsorption to surfaces (93% increase), homeostasis (67% increase), protein-protein interactions (40% increase) and carbohydrates (43% increase). New commercial systems have been released that are driving the uptake of the technology for characterization of binding specificities, affinities, kinetics and conformational changes associated with a molecular recognition event. This paper highlights theoretical and practical aspects of the principles that underpin acoustic analysis, then reviews exemplary papers in key application areas involving small molecular weight ligands, carbohydrates, proteins, nucleic acids, viruses, bacteria, cells and membrane interfaces.

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Highly Sensitive Biomolecule Detection on a Quartz Crystal Microbalance Using Gold Nanoparticles as Signal Amplification Probes

Cited by 33 publications

References 27 publications

Gold Nanoparticles in Chemical and Biological Sensing

Gold Nanoparticles in Chemical and Biological Sensing

Applications of Gold Nanoparticles in Non-Optical Biosensors

A survey of the 2006–2009 quartz crystal microbalance biosensor literature

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