Highly sensitive carboxyl-graphene oxide-based surface plasmon resonance immunosensor for the detection of lung cancer for cytokeratin 19 biomarker in human plasma

Chiu, Nan Fu; Lin, Ting; Kuo, Chia Tzu

doi:10.1016/j.snb.2018.03.070

Cited by 98 publications

(49 citation statements)

References 32 publications

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“…The functional group on the surface of the GO could fix a lot of antibodies. The presence of targets enabled obvious SPR changing, which allowed sensitive detection of cytokeratin 19 with a detection limit of 1 fg/mL [40]. Pang Ng et al presented a nickel-doped graphene localized SPR biosensor for detection of 3-nitro-l-tyrosine (3-NT), a biomarker of neurodegenerative diseases.…”

Section: Graphene-based Spr Biosensorsmentioning

confidence: 99%

Graphene-Based Biosensors for Detection of Biomarkers

2020

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The development of biosensors with high sensitivity and low-detection limits provides a new direction for medical and personal care. Graphene and graphene derivatives have been used to prepare various types of biosensors due to their excellent sensing performance (e.g., high specific surface area, extraordinary electronic properties, electron transport capabilities and ultrahigh flexibility). This perspective review focuses on graphene-based biosensors for quantitative detection of cancer-related biomarkers such as DNA, miRNA, small molecules and proteins by integrating with different signal outputting approaches including fluorescent, electrochemistry, surface plasmon resonance, surface enhanced Raman scattering, etc. The article also discussed their challenges and potential solutions along with future prospects.

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Section: Graphene-based Spr Biosensorsmentioning

confidence: 99%

Graphene-Based Biosensors for Detection of Biomarkers

2020

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“…Another interesting strategy used in developing SPR sensors is the use of molecularly imprinted polymers SPR sensors have also been widely explored for early stage cancer diagnosis [43][44][45][46][47][48][49]. They have been used for the detection of prominent cancer biomarkers such as cytokeratins [50][51][52], prostate specific antigen (PSA) [53][54][55], nucleic acids [56] and several other such molecules [57][58][59][60][61][62]. For example, Chen's group reported a label-free cytosensor for breast cancer diagnosis based on a mucin 1 aptamer immobilised gold substrate [63].…”

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

2020

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…Almost all of the reviewed papers containing calibration data report calibration on the basis of a linear calibration graph. Only two papers refer to semi-log calibration [19,24]. This appears to be a reasonable choice, because determination of the logarithm of the marker concentration does not satisfy expectations for clinical results.…”

Section: Go -Graphite Oxidementioning

confidence: 99%

Recent Progress in Surface Plasmon Resonance Biosensors  (2016 to Mid-2018)

Gorodkiewicz¹,

Łukaszewski²

2018

Preprint

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Almost 50 papers on surface plasmon resonance biosensors, published between 2016 and mid-2018, are reviewed. Papers concerning the determination of large particles such as vesicles, exosomes, cancer cells, living cells, stem cells and microRNA are excluded, as these are covered by a very recent review. The reviewed papers are categorized into five groups, depending on the degree of maturity of the reported solution: ranging from simple marker detection to clinical application of a previously developed biosensor. Instrumental solutions and details of biosensor construction are analyzed, including the chips, receptors and linkers used, as well as calibration strategies. Biosensors with a sandwich structure containing different nanoparticles are considered separately, as are SPR applications for investigating the interactions of biomolecules. An analysis is also made of the markers determined using the biosensors. Concluding, there is shown to be a growing number of SPR applications in the solution of real clinical problems.

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Highly sensitive carboxyl-graphene oxide-based surface plasmon resonance immunosensor for the detection of lung cancer for cytokeratin 19 biomarker in human plasma

Cited by 98 publications

References 32 publications

Graphene-Based Biosensors for Detection of Biomarkers

Graphene-Based Biosensors for Detection of Biomarkers

Recent Progress in Optical Sensors for Biomedical Diagnostics

Recent Progress in Surface Plasmon Resonance Biosensors  (2016 to Mid-2018)

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Highly sensitive carboxyl-graphene oxide-based surface plasmon resonance immunosensor for the detection of lung cancer for cytokeratin 19 biomarker in human plasma

Cited by 98 publications

References 32 publications

Graphene-Based Biosensors for Detection of Biomarkers

Graphene-Based Biosensors for Detection of Biomarkers

Recent Progress in Optical Sensors for Biomedical Diagnostics

Recent Progress in Surface Plasmon Resonance Biosensors &nbsp;(2016 to Mid-2018)

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Recent Progress in Surface Plasmon Resonance Biosensors (2016 to Mid-2018)