2010
DOI: 10.1016/j.aca.2010.07.033
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Highly sensitive electrochemiluminescence displacement method for the study of DNA/small molecule binding interactions

Abstract: a b s t r a c tNon-covalent binding interactions of small molecules with DNA play important roles in regulating gene expression and gene function. In this work, a highly sensitive electrochemiluminescence (ECL) displacement method has been developed to investigate such interactions, particularly for weak DNA binders. This ECL method relies on a double-stranded DNA film deposited on an indium tin oxide electrode (ITO) surface by layer-by-layer self-assembly. A DNA intercalator, [Ru(bpy) 2 (dppz)] 2+ (bpy = 2,2 … Show more

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Cited by 18 publications
(2 citation statements)
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“…Due to its high sensitivity and selectivity, detection of DNA using ECL method has drawn much attention from all over the world [72,75,76,100,156,172,173,174,175,176,177,178,179,180]. Table 1 summarizes the performances of selected ECL detection approaches listed in this review.…”
Section: Electrochemiluminescent Methodsmentioning
confidence: 99%
“…Due to its high sensitivity and selectivity, detection of DNA using ECL method has drawn much attention from all over the world [72,75,76,100,156,172,173,174,175,176,177,178,179,180]. Table 1 summarizes the performances of selected ECL detection approaches listed in this review.…”
Section: Electrochemiluminescent Methodsmentioning
confidence: 99%
“…There has been considerable interest in the binding studies of small molecules with DNA owing to their diverse applications 10 . DNA is the pharmacological target of many drugs that are currently in clinical use or are in advanced clinical trials [11][12] . DNA has been the recognition and characterization site for the interaction of small molecules as they yield effective information for the development of therapeutic agents for controlling gene expressions [13][14] .…”
Section: Introductionmentioning
confidence: 99%