Highly Sensitive Fluorescence Methods for the Determination of Alfuzosin, Doxazosin, Terazosin and Prazosin in Pharmaceutical Formulations, Plasma and Urine

Abstract

Polymeric ionic liquid-coated magnetic nanoparticles have been successfully prepared as adsorbents for the magnetic solid-phase extraction of four drugs, namely alfuzosin, doxazosin, terazosin and prazosin, from pharmaceutical preparations, urine samples and plasma samples. The four drugs were detected by fluorescence spectrophotometer. Several extraction parameters, including the pH of the solution; the type, ratio and volume of the desorbing reagent; the amount of adsorbent; the time of the extraction and desorption processes; and the addition of NaCl, were investigated and optimized. Linear responses were determined for the four drugs in the concentration range of 0.5 - 45 ng mL(-1). The limit of detection values for alfuzosin, doxazosin, terazosin and prazosin, which were defined as three times the standard deviation of a blank sample, were determined to be 0.035, 0.034, 0.027 and 0.028 ng mL(-1) (n = 11), respectively. Furthermore, this new method gave preconcentration factors of 114.5, 111.3, 111.1 and 108.5 for these four drugs.

Distribution Equilibria of Amphoteric 8-Quinolinol between 1-Alkyl-3-methylimidazolium Bis(trifluoromethanesulfonyl)imide and Aqueous Phases and Their Effect on Ionic Liquid Chelate Extraction Behavior of Iron(III)

“…ILs are also used in analytical chemistry, including electroanalytical chemistry 2,3 and separation chemistry. [4][5][6][7] Solvent extraction of metal cations is a separation technique using large amounts of hydrophobic organic solvents for the extraction phase materials.…”

Synthesis of magnetic polymeric ionic liquid nanocomposites by the Radziszewski reaction

“…The complete process took 42 h, without considering the time for washing and purication steps. Other authors 27,30 have reported similar reaction times, temperatures and inert atmosphere to obtain the nal PIL magnetic nanocomposite.…”

Preconcentration and Detection of Gefitinib Anti-Cancer Drug Traces from Water and Human Plasma Samples by Means of Magnetic Nanoparticles

“…The desorption of our target analyte from the surface of the SDS-coated MNPs can be obtained by adding organic solvents as reported in previous works [ 24 , 27 , 28 , 29 ]. It was found that organic solvents can disrupt the formed hemimicelles/admicelles, which diminishes the available place for GEF adsorption.…”